SUMO-1 conjugation to intact DNA topoisomerase I amplifies cleavable complex formation induced by camptothecin.
about
SUMO-mediated regulation of DNA damage repair and responsesSUMO-targeted ubiquitin ligase, Rad60, and Nse2 SUMO ligase suppress spontaneous Top1-mediated DNA damage and genome instability.Tyrosyl-DNA-phosphodiesterases (TDP1 and TDP2).Slx8 removes Pli1-dependent protein-SUMO conjugates including SUMOylated topoisomerase I to promote genome stability.Molecular targeting therapy of cancer: drug resistance, apoptosis and survival signal.Topoisomerase I-dependent viability loss in saccharomyces cerevisiae mutants defective in both SUMO conjugation and DNA repair.SUMO modification of DNA topoisomerase II: trying to get a CENse of it allUbiquitin-family modifications of topoisomerase I in camptothecin-treated human breast cancer cells.Interaction between glucose-regulated destruction domain of DNA topoisomerase IIalpha and MPN domain of Jab1/CSN5.SUMO modification of the neuroprotective protein TDP1 facilitates chromosomal single-strand break repair.A Lysine Desert Protects a Novel Domain in the Slx5-Slx8 SUMO Targeted Ub Ligase To Maintain Sumoylation Levels in Saccharomyces cerevisiae.The E3 ligase Topors induces the accumulation of polysumoylated forms of DNA topoisomerase I in vitro and in vivo.Assembly of a polymeric chain of SUMO1 on human topoisomerase I in vitro.Transcriptional activity of peroxisome proliferator-activated receptor gamma is modulated by SUMO-1 modification.Distinct effects of topoisomerase I and RNA polymerase I inhibitors suggest a dual mechanism of nucleolar/nucleoplasmic partitioning of topoisomerase I.RECQ5-dependent SUMOylation of DNA topoisomerase I prevents transcription-associated genome instability.Association of SUMO1 and UBC9 genotypes with tumor response in non-small-cell lung cancer treated with irinotecan-based chemotherapy.MEK-ERK is involved in SUMO-1 foci formation on apoptosis.Defects in SUMO (small ubiquitin-related modifier) conjugation and deconjugation alter cell sensitivity to DNA topoisomerase I-induced DNA damage.
P2860
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P2860
SUMO-1 conjugation to intact DNA topoisomerase I amplifies cleavable complex formation induced by camptothecin.
description
2002 nî lūn-bûn
@nan
2002年の論文
@ja
2002年学术文章
@wuu
2002年学术文章
@zh
2002年学术文章
@zh-cn
2002年学术文章
@zh-hans
2002年学术文章
@zh-my
2002年学术文章
@zh-sg
2002年學術文章
@yue
2002年學術文章
@zh-hant
name
SUMO-1 conjugation to intact D ...... ation induced by camptothecin.
@en
SUMO-1 conjugation to intact D ...... ation induced by camptothecin.
@nl
type
label
SUMO-1 conjugation to intact D ...... ation induced by camptothecin.
@en
SUMO-1 conjugation to intact D ...... ation induced by camptothecin.
@nl
prefLabel
SUMO-1 conjugation to intact D ...... ation induced by camptothecin.
@en
SUMO-1 conjugation to intact D ...... ation induced by camptothecin.
@nl
P2093
P2860
P356
P1433
P1476
SUMO-1 conjugation to intact D ...... ation induced by camptothecin.
@en
P2093
Akihiro Tomida
Hiroyuki Yoshikawa
Koji Horie
Takashi Tsuruo
Toshiharu Yasugi
Yoshikazu Sugimoto
Yuji Taketani
P2860
P2888
P304
P356
10.1038/SJ.ONC.1205917
P407
P577
2002-11-01T00:00:00Z
P5875
P6179
1050474966