about
The role of poly(ADP-ribose) in the DNA damage signaling networkThe role of lysine 532 in the catalytic mechanism of human topoisomerase IInhibition of topoisomerase I cleavage activity by thiol-reactive compounds: importance of vicinal cysteines 504 and 505Phosphorylation of DNA topoisomerase I by the c-Abl tyrosine kinase confers camptothecin sensitivitySubnuclear distribution of topoisomerase I is linked to ongoing transcription and p53 statusEffect on DNA relaxation of the single Thr718Ala mutation in human topoisomerase I: a functional and molecular dynamics studyRotation of DNA around intact strand in human topoisomerase I implies distinct mechanisms for positive and negative supercoil relaxationDrugging topoisomerases: lessons and challengesAsymmetric DNA bending in the Cre-loxP site-specific recombination synapseA nicked duplex decamer DNA with a PEG(6) tether8-Oxoguanine rearranges the active site of human topoisomerase INonlinear partial differential equations and applications: The mechanism of topoisomerase I poisoning by a camptothecin analogStructural impact of the leukemia drug 1-beta-D-arabinofuranosylcytosine (Ara-C) on the covalent human topoisomerase I-DNA complexThe role of the conserved Trp330 in Flp-mediated recombination. Functional and structural analysisAn Interlocked Dimer of the Protelomerase TelK Distorts DNA Structure for the Formation of Hairpin TelomeresInsights from the Structure of a Smallpox Virus Topoisomerase-DNA Transition State MimicStructures of Minimal Catalytic Fragments of Topoisomerase V Reveals Conformational Changes Relevant for DNA BindingA newly identified essential complex, Dre2-Tah18, controls mitochondria integrity and cell death after oxidative stress in yeast.Role for nucleolin/Nsr1 in the cellular localization of topoisomerase I.The integrase family of recombinase: organization and function of the active siteTopoisomerase V relaxes supercoiled DNA by a constrained swiveling mechanismUnveiling hidden catalytic contributions of the conserved His/Trp-III in tyrosine recombinases: assembly of a novel active site in Flp recombinase harboring alanine at this positionCaspase-mediated cleavage of DNA topoisomerase I at unconventional sites during apoptosisAntifungal activities of antineoplastic agents: Saccharomyces cerevisiae as a model system to study drug actionComparison of in vitro activities of camptothecin and nitidine derivatives against fungal and cancer cellsStructural and dynamical effects induced by the anticancer drug topotecan on the human topoisomerase I - DNA complexExploring DNA topoisomerase I ligand space in search of novel anticancer agentsBinding of an Indenoisoquinoline to the topoisomerase-DNA complex induces reduction of linker mobility and strengthening of protein-DNA interactionApplication of a novel microtitre plate-based assay for the discovery of new inhibitors of DNA gyrase and DNA topoisomerase VIReplacement of the human topoisomerase linker domain with the plasmodial counterpart renders the enzyme camptothecin resistantTheoretical and experimental studies of new modified isoflavonoids as potential inhibitors of topoisomerase I from Plasmodium falciparumNitric Oxide Down-Regulates Topoisomerase I and Induces Camptothecin Resistance in Human Breast MCF-7 Tumor CellsResidues 190-210 of human topoisomerase I are required for enzyme activity in vivo but not in vitroThe structure–activity relationships of A-ring-substituted aromathecin topoisomerase I inhibitors strongly support a camptothecin-like binding modeDNA Topoisomerase I Inhibitors: Chemistry, Biology, and Interfacial InhibitionDesign, Synthesis, and Evaluation of Dibenzo[c,h][1,6]naphthyridines as Topoisomerase I Inhibitors and Potential Anticancer AgentsThe open state of human topoisomerase I as probed by molecular dynamics simulationOverview of protein structural and functional folds.Single-Molecule Supercoil Relaxation Assay as a Screening Tool to Determine the Mechanism and Efficacy of Human Topoisomerase IB Inhibitors.RNA Polymerase II Regulates Topoisomerase 1 Activity to Favor Efficient Transcription.
P2860
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P2860
description
1998 nî lūn-bûn
@nan
1998 թուականի Մարտին հրատարակուած գիտական յօդուած
@hyw
1998 թվականի մարտին հրատարակված գիտական հոդված
@hy
1998年の論文
@ja
1998年学术文章
@wuu
1998年学术文章
@zh-cn
1998年学术文章
@zh-hans
1998年学术文章
@zh-my
1998年学术文章
@zh-sg
1998年學術文章
@yue
name
A model for the mechanism of human topoisomerase I
@ast
A model for the mechanism of human topoisomerase I
@en
A model for the mechanism of human topoisomerase I
@nl
type
label
A model for the mechanism of human topoisomerase I
@ast
A model for the mechanism of human topoisomerase I
@en
A model for the mechanism of human topoisomerase I
@nl
prefLabel
A model for the mechanism of human topoisomerase I
@ast
A model for the mechanism of human topoisomerase I
@en
A model for the mechanism of human topoisomerase I
@nl
P2093
P3181
P1433
P1476
A model for the mechanism of human topoisomerase I
@en
P2093
P304
P3181
P356
10.1126/SCIENCE.279.5356.1534
P407
P577
1998-03-06T00:00:00Z