In IGF-I receptor-deficient leiomyosarcoma cells autocrine IGF-II induces cell invasion and protection from apoptosis via the insulin receptor isoform A.
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PPAR-γ agonists and their effects on IGF-I receptor signaling: Implications for cancerActivation of the insulin receptor by insulin and a synthetic peptide leads to divergent metabolic and mitogenic signaling and responsesNuclear IGF1R is a transcriptional co-activator of LEF1/TCFThe insulin receptor is essential for virus-induced tumorigenesis of Kaposi's sarcomaDifferential gene expression induced by insulin and insulin-like growth factor-II through the insulin receptor isoform AObesity and cancer, a case for insulin signalingMetformin as an adjuvant drug against pediatric sarcomas: hypoxia limits therapeutic effects of the drugEngineering of insulin receptor isoform-selective insulin analoguesDoege-Potter syndrome: A review of the literature including a new case report.In vitro metabolic and mitogenic signaling of insulin glargine and its metabolitesHuman biliverdin reductase-based peptides activate and inhibit glucose uptake through direct interaction with the kinase domain of insulin receptorDecorin differentially modulates the activity of insulin receptor isoform A ligands.Decreased expression of insulin-like growth factor binding protein 6 is associated with gastric adenocarcinoma prognosis.Widespread alternative exon usage in clinically distinct subtypes of Invasive Ductal CarcinomaInsulin-like growth factor 2 expression modulates Taxol resistance and is a candidate biomarker for reduced disease-free survival in ovarian cancer.Inhibition of the insulin-like growth factor-1 receptor (IGF1R) tyrosine kinase as a novel cancer therapy approachDiscovery of OSI-906: a selective and orally efficacious dual inhibitor of the IGF-1 receptor and insulin receptor.Reduced insulin-like growth factor I receptor and altered insulin receptor isoform mRNAs in normal mucosa predict colorectal adenoma risk.Constitutive activation with overexpression of the mTORC2-phospholipase D1 pathway in uterine leiomyosarcoma and STUMP: morphoproteomic analysis with therapeutic implications.Ligand-mediated endocytosis and trafficking of the insulin-like growth factor receptor I and insulin receptor modulate receptor function.Overexpression of the insulin receptor isoform A promotes endometrial carcinoma cell growth.Phase I dose-escalation study of MEDI-573, a bispecific, antiligand monoclonal antibody against IGFI and IGFII, in patients with advanced solid tumorsThe therapeutic potential of agents targeting the type I insulin-like growth factor receptor.The insulin receptor: a new target for cancer therapy.Role of insulin-like growth factor 1 receptor signalling in cancer.Treatment of hematologic malignancies and solid tumors by inhibiting IGF receptor signaling.IGF1 and IGF2 specificities to the two insulin receptor isoforms are determined by insulin receptor amino acid 718.Glypican-3-mediated oncogenesis involves the Insulin-like growth factor-signaling pathwayA twenty-first century cancer epidemic caused by obesity: the involvement of insulin, diabetes, and insulin-like growth factorsComparative transcriptomic analysis reveals the oncogenic fusion protein PAX3-FOXO1 globally alters mRNA and miRNA to enhance myoblast invasion.Insulin receptor isoform switching in intestinal stem cells, progenitors, differentiated lineages and tumors: evidence that IR-B limits proliferation.Precursor IGF-II (proIGF-II) and mature IGF-II (mIGF-II) induce Bcl-2 And Bcl-X L expression through different signaling pathways in breast cancer cells.PPAR-γ Agonists As Antineoplastic Agents in Cancers with Dysregulated IGF Axis.Molecular biology of squamous cell carcinoma of the head and neck: relevance and therapeutic implications.Biology and significance of signalling pathways activated by IGF-II.Diabetes and cancer relationships.Insulin receptor isoforms: an integrated view focused on gestational diabetes mellitus.Insulin-Like Growth Factor-II/Cation-Independent Mannose 6-Phosphate Receptor in Neurodegenerative Diseases.Insulin, insulin receptors, and cancer.Nuclear translocation of IGF-1R via p150(Glued) and an importin-β/RanBP2-dependent pathway in cancer cells.
P2860
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P2860
In IGF-I receptor-deficient leiomyosarcoma cells autocrine IGF-II induces cell invasion and protection from apoptosis via the insulin receptor isoform A.
description
2002 nî lūn-bûn
@nan
2002年の論文
@ja
2002年学术文章
@wuu
2002年学术文章
@zh-cn
2002年学术文章
@zh-hans
2002年学术文章
@zh-my
2002年学术文章
@zh-sg
2002年學術文章
@yue
2002年學術文章
@zh
2002年學術文章
@zh-hant
name
In IGF-I receptor-deficient le ...... he insulin receptor isoform A.
@en
In IGF-I receptor-deficient le ...... he insulin receptor isoform A.
@nl
type
label
In IGF-I receptor-deficient le ...... he insulin receptor isoform A.
@en
In IGF-I receptor-deficient le ...... he insulin receptor isoform A.
@nl
prefLabel
In IGF-I receptor-deficient le ...... he insulin receptor isoform A.
@en
In IGF-I receptor-deficient le ...... he insulin receptor isoform A.
@nl
P2093
P50
P356
P1433
P1476
In IGF-I receptor-deficient le ...... the insulin receptor isoform A
@en
P2093
Antonella Murabito
Giuseppe Pandini
Rossana Mineo
P2888
P304
P356
10.1038/SJ.ONC.1206058
P407
P577
2002-11-01T00:00:00Z