SOCS-1, a negative regulator of cytokine signaling, is frequently silenced by methylation in multiple myeloma.
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Downregulation of p53-inducible microRNAs 192, 194, and 215 impairs the p53/MDM2 autoregulatory loop in multiple myeloma developmentMicroRNAs regulate critical genes associated with multiple myeloma pathogenesisPhysiological and pathological implications of 5-hydroxymethylcytosine in diseasesThe role of suppressors of cytokine signalling in human neoplasmsDrug resistance in multiple myeloma: latest findings and new concepts on molecular mechanisms.STAT3 as a therapeutic target in head and neck cancerGene expression profiling reveals different pathways related to Abl and other genes that cooperate with c-Myc in a model of plasma cell neoplasia.Favorable prognostic value of SOCS2 and IGF-I in breast cancer.Higher expression levels of SOCS 1,3,4,7 are associated with earlier tumour stage and better clinical outcome in human breast cancer.SOCS-3 is frequently silenced by hypermethylation and suppresses cell growth in human lung cancerGlobal methylation and promoter-specific methylation of the P16, SOCS-1, E-cadherin, P73 and SHP-1 genes and their expression in patients with multiple myeloma during active disease and remissionMicroRNA: important player in the pathobiology of multiple myelomaSTAT3 Activity and Function in Cancer: Modulation by STAT5 and miR-146b.HGF/c-met/Stat3 signaling during skin tumor cell invasion: indications for a positive feedback loop.Knockdown of DNA methyltransferase-1 inhibits proliferation and derepresses tumor suppressor genes in myeloma cells.STAT-3 correlates with lymph node metastasis and cell survival in gastric cancerInterleukin-6 and new strategies for the treatment of cancer, hyperproliferative diseases and paraneoplastic syndromes.Enforced SOCS1 and SOCS3 expression attenuates Lck-mediated cellular transformation.A SOCS-1 promoter variant is associated with total serum IgE levels.Suppressor of cytokine signalling 2 (SOCS-2) expression in breast carcinoma.Association of SOCS1 (- 820) (rs33977706) gene polymorphism with chronic periodontitis: A case-control study in BraziliansInhibition of DNA methyltransferase induces G2 cell cycle arrest and apoptosis in human colorectal cancer cells via inhibition of JAK2/STAT3/STAT5 signalling.STAT proteins as novel targets for cancer drug discovery.Signal transducers and activators of transcription: insights into the molecular basis of oral cancer.Developmental origins of adult disease.Upregulation of miR-572 transcriptionally suppresses SOCS1 and p21 and contributes to human ovarian cancer progression.A requirement for SOCS-1 and SOCS-3 phosphorylation in Bcr-Abl-induced tumorigenesis.Genome-scale analysis of DNA methylation in lung adenocarcinoma and integration with mRNA expression.On the epigenetics of vascular regulation and diseaseEpigenetic regulation of signal transducer and activator of transcription 3 in acute myeloid leukemiaAnalysis of methylation pattern in multiple myeloma.Growth factors and antiapoptotic signaling pathways in multiple myeloma.Abnormal repression of SHP-1, SHP-2 and SOCS-1 transcription sustains the activation of the JAK/STAT3 pathway and the progression of the disease in multiple myeloma.SOCS1: a potent and multifaceted regulator of cytokines and cell-mediated inflammation.Diabetic and metabolic programming: mechanisms altering the intrauterine milieuHighly synergistic effect of sequential treatment with epigenetic and anticancer drugs to overcome drug resistance in breast cancer cells is mediated via activation of p21 gene expression leading to G2/M cycle arrest.The role of Janus kinases in haemopoiesis and haematological malignancy.Aberrant methylation of suppressor of cytokine signalling-1 (SOCS-1) gene in pancreatic ductal neoplasms.Epigenetic silencing of tumor suppressor miR-3151 contributes to Chinese chronic lymphocytic leukemia by constitutive activation of MADD/ERK and PIK3R2/AKT signaling pathways.Constitutional activation of IL-6-mediated JAK/STAT pathway through hypermethylation of SOCS-1 in human gastric cancer cell line
P2860
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P2860
SOCS-1, a negative regulator of cytokine signaling, is frequently silenced by methylation in multiple myeloma.
description
2002 nî lūn-bûn
@nan
2002年の論文
@ja
2002年学术文章
@wuu
2002年学术文章
@zh
2002年学术文章
@zh-cn
2002年学术文章
@zh-hans
2002年学术文章
@zh-my
2002年学术文章
@zh-sg
2002年學術文章
@yue
2002年學術文章
@zh-hant
name
SOCS-1, a negative regulator o ...... thylation in multiple myeloma.
@en
SOCS-1, a negative regulator o ...... thylation in multiple myeloma.
@nl
type
label
SOCS-1, a negative regulator o ...... thylation in multiple myeloma.
@en
SOCS-1, a negative regulator o ...... thylation in multiple myeloma.
@nl
prefLabel
SOCS-1, a negative regulator o ...... thylation in multiple myeloma.
@en
SOCS-1, a negative regulator o ...... thylation in multiple myeloma.
@nl
P2093
P1433
P1476
SOCS-1, a negative regulator o ...... thylation in multiple myeloma.
@en
P2093
Hirohide Yoshikawa
James G Herman
Oliver Galm
Rainhardt Osieka
P304
P356
10.1182/BLOOD-2002-06-1735
P407
P577
2002-11-27T00:00:00Z