N-terminal phosphorylation of cardiac troponin-I reduces length-dependent calcium sensitivity of contraction in cardiac muscle.
about
Gene regulation, alternative splicing, and posttranslational modification of troponin subunits in cardiac development and adaptation: a focused reviewLength-dependent activation is modulated by cardiac troponin I bisphosphorylation at Ser23 and Ser24 but not by Thr143 phosphorylationTNNI1, TNNI2 and TNNI3: Evolution, regulation, and protein structure-function relationships.PKA phosphorylation of cardiac troponin I modulates activation and relaxation kinetics of ventricular myofibrils.Computational studies of the effect of the S23D/S24D troponin I mutation on cardiac troponin structural dynamics.The dilated cardiomyopathy-causing mutation ACTC E361G in cardiac muscle myofibrils specifically abolishes modulation of Ca(2+) regulation by phosphorylation of troponin I2-Deoxy adenosine triphosphate improves contraction in human end-stage heart failure.Familial hypertrophic cardiomyopathy related cardiac troponin C L29Q mutation alters length-dependent activation and functional effects of phosphomimetic troponin I*Distinct conformational and functional effects of two adjacent pathogenic mutations in cardiac troponin I at the interface with troponin T.Troponin I Mutations R146G and R21C Alter Cardiac Troponin Function, Contractile Properties, and Modulation by Protein Kinase A (PKA)-mediated Phosphorylation.Cardiac Myosin-binding Protein C and Troponin-I Phosphorylation Independently Modulate Myofilament Length-dependent Activation.Cardiac troponin structure-function and the influence of hypertrophic cardiomyopathy associated mutations on modulation of contractility.Restrictive Cardiomyopathy Troponin I R145W Mutation Does Not Perturb Myofilament Length-dependent Activation in Human Cardiac Sarcomeres.Length dependence of striated muscle force generation is controlled by phosphorylation of cTnI at serines 23/24.
P2860
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P2860
N-terminal phosphorylation of cardiac troponin-I reduces length-dependent calcium sensitivity of contraction in cardiac muscle.
description
2012 nî lūn-bûn
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2012年の論文
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2012年学术文章
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2012年学术文章
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name
N-terminal phosphorylation of ...... contraction in cardiac muscle.
@en
N-terminal phosphorylation of ...... contraction in cardiac muscle.
@nl
type
label
N-terminal phosphorylation of ...... contraction in cardiac muscle.
@en
N-terminal phosphorylation of ...... contraction in cardiac muscle.
@nl
prefLabel
N-terminal phosphorylation of ...... contraction in cardiac muscle.
@en
N-terminal phosphorylation of ...... contraction in cardiac muscle.
@nl
P2093
P2860
P1476
N-terminal phosphorylation of ...... contraction in cardiac muscle.
@en
P2093
Donald A Martyn
Erik R Feest
F Steven Korte
Hsiaoman Hsu
Maria V Razumova
Michael Regnier
Thomas C Irving
Vijay S Rao
P2860
P304
P356
10.1113/JPHYSIOL.2012.241604
P407
P577
2012-11-05T00:00:00Z