In vitro effects of polyglutamine tracts on Ca2+-dependent depolarization of rat and human mitochondria: relevance to Huntington's disease.
about
Metabolic dysfunction in Alzheimer's disease and related neurodegenerative disordersMelatonin in Alzheimer's disease and other neurodegenerative disordersUnbiased gene expression analysis implicates the huntingtin polyglutamine tract in extra-mitochondrial energy metabolismInhibition of calpain cleavage of huntingtin reduces toxicity: accumulation of calpain/caspase fragments in the nucleusA randomized, placebo-controlled trial of latrepirdine in Huntington disease.Blood brain barrier: the role of calcium homeostasis.Smart MR imaging agents relevant to potential neurologic applications.MRI probes for sensing biologically relevant metal ions.Type 2 transglutaminase in Huntington's disease: a double-edged sword with clinical potential.Cardiac dysfunction in the R6/2 mouse model of Huntington's diseaseCa(2+) handling in isolated brain mitochondria and cultured neurons derived from the YAC128 mouse model of Huntington's diseaseOxidative metabolism in YAC128 mouse model of Huntington's disease.The mitochondrial permeability transition in neurologic diseaseImpaired regulation of brain mitochondria by extramitochondrial Ca2+ in transgenic Huntington disease ratsA role of mitochondrial complex II defects in genetic models of Huntington's disease expressing N-terminal fragments of mutant huntingtinMitochondrial calcium function and dysfunction in the central nervous system.Oxidative metabolism and Ca2+ handling in isolated brain mitochondria and striatal neurons from R6/2 mice, a model of Huntington's disease.Mitochondria and energetic depression in cell pathophysiologyProteomic analysis of mitochondrial dysfunction in neurodegenerative diseases.Molecular mechanisms and potential therapeutical targets in Huntington's disease.Pathophysiology of Huntington's disease: time-dependent alterations in synaptic and receptor function.Energy dysfunction in Huntington's disease: insights from PGC-1α, AMPK, and CKB.Neuronal calcium signaling: function and dysfunction.Mutant Huntingtin and Elusive Defects in Oxidative Metabolism and Mitochondrial Calcium Handling.Oxidative metabolism and Ca2+ handling in striatal mitochondria from YAC128 mice, a model of Huntington's disease.Compromised mitochondrial complex II in models of Machado-Joseph disease.Mutant Huntingtin induces activation of the Bcl-2/adenovirus E1B 19-kDa interacting protein (BNip3)Huntingtin inclusion bodies are iron-dependent centers of oxidative events.Calcium signaling in neurodegenerationThe first 17 amino acids of Huntingtin modulate its sub-cellular localization, aggregation and effects on calcium homeostasis.Enhanced Akt signaling is an early pro-survival response that reflects N-methyl-D-aspartate receptor activation in Huntington's disease knock-in striatal cells.Olesoxime suppresses calpain activation and mutant huntingtin fragmentation in the BACHD rat.Proteomic analysis of protein expression and oxidative modification in r6/2 transgenic mice: a model of Huntington disease.HD CAG repeat implicates a dominant property of huntingtin in mitochondrial energy metabolism.Selective deficits in the expression of striatal-enriched mRNAs in Huntington's disease.Analysis of oxidative events induced by expanded polyglutamine huntingtin exon 1 that are differentially restored by expression of heat shock proteins or treatment with an antioxidant.
P2860
Q24562763-478D1CC7-F432-46EC-A79B-4952CA002F6FQ28217483-CD8285B8-FFFC-465A-9A68-ACA202759061Q28469280-11F696D2-B56F-4039-A5F4-EE29029DC1C8Q28505053-9464DF2F-A624-43AC-8943-7CF55B98FE19Q30411257-B3A920C2-BFB6-4BF7-932C-15904B780494Q30436341-1BAA9BBE-4DF1-4F7D-85CB-F0416AF74B8AQ33510867-67D1D469-48EB-4862-9CBF-883A7DFBF983Q33852470-1D3CFC57-FBCC-4C67-9CE9-B10C4AE3F753Q34775357-F541F648-59C9-4A68-9455-CF89BC117C11Q35745626-5D81DAD6-CF4A-45A9-BB11-7A8D7DBD7AD3Q35893954-5C22A6AD-CFB9-4FA9-9F23-C6C4491D8834Q35924062-714702EE-104A-4B6D-ADD2-FB3CB9D96389Q36775895-8A495153-79D7-4919-B00F-2FBA9590B0E4Q37142702-947A8318-5555-4BAD-A721-CD843CE362E9Q37153804-0276442B-54B2-4778-B4B4-B200CCCDBD30Q37418288-56AE4466-7B55-43E4-931C-351BACDD8D40Q37530288-EE8919FC-9213-476E-B218-E5475C77959AQ37535535-55FF8EDA-C4C0-4B6E-83E7-5383CA3D4DF8Q37775036-ABC7A2BA-12C5-4AD2-8105-22839299C643Q37776087-0DABE515-BBCE-4D59-A447-DB7D2C2BE91FQ37930190-C6CA71B5-EEBA-4890-9EE3-04B370153DC1Q38013005-4AF60769-F0A9-4BB2-8872-87FE46E56FC5Q38179996-CD11F993-82F8-41C7-8B64-1D1BD9EC92F9Q38458943-C0CCB257-004B-4632-B1AD-FEF35A39ABA6Q39035184-F66E26E1-FFFF-407A-A4E0-EC66C1720EBAQ39450953-7E340D63-98C3-471D-A331-D7A203F0D3CBQ39757740-248979DF-A6B8-480A-99CD-4E11B6BC3811Q40206245-CB9BD2CB-0C94-4ED1-AAD1-536D89EFB37AQ42199396-ABA6CE27-5B57-480A-94D3-B402063158B7Q44376761-9BBD2C7C-D178-4A24-A322-51E285261B35Q44605170-67368A33-C257-4FAB-9837-6A7D5B74D8A3Q45290815-B78B821C-25B0-4C6A-9C53-C968A2E51165Q45297228-4B99A4DD-32D8-4B2C-84DA-BFB5EF956E93Q45298206-22BE109F-6086-4456-ADC6-951569FD2014Q45299732-F8DA1F88-F36E-481A-BE39-4A2ED8BD9410Q52571894-703B30DD-E260-4023-85D4-126E92484FCE
P2860
In vitro effects of polyglutamine tracts on Ca2+-dependent depolarization of rat and human mitochondria: relevance to Huntington's disease.
description
2003 nî lūn-bûn
@nan
2003年の論文
@ja
2003年学术文章
@wuu
2003年学术文章
@zh-cn
2003年学术文章
@zh-hans
2003年学术文章
@zh-my
2003年学术文章
@zh-sg
2003年學術文章
@yue
2003年學術文章
@zh
2003年學術文章
@zh-hant
name
In vitro effects of polyglutam ...... vance to Huntington's disease.
@en
In vitro effects of polyglutam ...... vance to Huntington's disease.
@nl
type
label
In vitro effects of polyglutam ...... vance to Huntington's disease.
@en
In vitro effects of polyglutam ...... vance to Huntington's disease.
@nl
prefLabel
In vitro effects of polyglutam ...... vance to Huntington's disease.
@en
In vitro effects of polyglutam ...... vance to Huntington's disease.
@nl
P1476
In vitro effects of polyglutam ...... evance to Huntington's disease
@en
P2093
Alexander V Panov
Warren J Strittmatter
P356
10.1016/S0003-9861(02)00585-4
P407
P577
2003-02-01T00:00:00Z