Targeting presenilin-type aspartic protease signal peptide peptidase with gamma-secretase inhibitors.
about
A gamma-secretase-like intramembrane cleavage of TNFalpha by the GxGD aspartyl protease SPPL2bSPPL2a and SPPL2b promote intramembrane proteolysis of TNFalpha in activated dendritic cells to trigger IL-12 productionHuman CRB2 inhibits gamma-secretase cleavage of amyloid precursor protein by binding to the presenilin complexIntramembrane processing by signal peptide peptidase regulates the membrane localization of hepatitis C virus core protein and viral propagationTargeting γ-secretase in breast cancerToward the structure of presenilin/γ-secretase and presenilin homologsCore protein cleavage by signal peptide peptidase is required for hepatitis C virus-like particle assemblyRequirement of the proteasome for the trimming of signal peptide-derived epitopes presented by the nonclassical major histocompatibility complex class I molecule HLA-EAn internal signal sequence directs intramembrane proteolysis of a cellular immunoglobulin domain proteinA C-terminal region of signal peptide peptidase defines a functional domain for intramembrane aspartic protease catalysisIdentification of an archaeal presenilin-like intramembrane proteaseDifferential Inhibition of Signal Peptide Peptidase Family Members by Established γ-Secretase InhibitorsGamma-secretase composed of PS1/Pen2/Aph1a can cleave notch and amyloid precursor protein in the absence of nicastrinCellular functions of gamma-secretase-related proteins.A small molecule inhibitor of signal peptide peptidase inhibits Plasmodium development in the liver and decreases malaria severity.γ-Secretase Inhibitors and Modulators Induce Distinct Conformational Changes in the Active Sites of γ-Secretase and Signal Peptide PeptidaseInhibitors of signal peptide peptidase (SPP) affect HSV-1 infectivity in vitro and in vivo.Foamy virus envelope protein is a substrate for signal peptide peptidase-like 3 (SPPL3).Structure, mechanism and inhibition of gamma-secretase and presenilin-like proteasesTargeting the ERAD pathway via inhibition of signal peptide peptidase for antiparasitic therapeutic designDrosophila signal peptide peptidase is an essential protease for larval development.Visualizing active enzyme complexes using a photoreactive inhibitor for proximity ligation--application on γ-secretase.A role for Notch signaling in trophoblast endovascular invasion and in the pathogenesis of pre-eclampsia.Three-dimensional structure of the signal peptide peptidaseMechanisms of hepatitis C virus infection.Membrane proteases in the bacterial protein secretion and quality control pathway.Presenilin function and gamma-secretase activity.Protease inhibitors as potential disease-modifying therapeutics for Alzheimer's disease.Current experimental therapy for Alzheimer's diseaseTRC8-dependent degradation of hepatitis C virus immature core protein regulates viral propagation and pathogenesisDistinct pharmacological effects of inhibitors of signal peptide peptidase and gamma-secretase.Substrate specificity of gamma-secretase and other intramembrane proteases.Intraneuronal aggregation of the β-CTF fragment of APP (C99) induces Aβ-independent lysosomal-autophagic pathology.Intramembrane proteolysisPresenilins: members of the gamma-secretase quartets, but part-time soloists too.Presenilins, Notch dose control the fate of pancreatic endocrine progenitors during a narrow developmental window.Intramembrane proteolysis by signal peptide peptidases: a comparative discussion of GXGD-type aspartyl proteases.Pigment epithelium-derived factor maintains retinal pigment epithelium function by inhibiting vascular endothelial growth factor-R2 signaling through gamma-secretasePlasmodium falciparum signal peptide peptidase is a promising drug target against blood stage malaria.Structural biology of presenilins and signal peptide peptidases.
P2860
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P2860
Targeting presenilin-type aspartic protease signal peptide peptidase with gamma-secretase inhibitors.
description
2003 nî lūn-bûn
@nan
2003年の論文
@ja
2003年学术文章
@wuu
2003年学术文章
@zh
2003年学术文章
@zh-cn
2003年学术文章
@zh-hans
2003年学术文章
@zh-my
2003年学术文章
@zh-sg
2003年學術文章
@yue
2003年學術文章
@zh-hant
name
Targeting presenilin-type aspa ...... th gamma-secretase inhibitors.
@en
Targeting presenilin-type aspa ...... th gamma-secretase inhibitors.
@nl
type
label
Targeting presenilin-type aspa ...... th gamma-secretase inhibitors.
@en
Targeting presenilin-type aspa ...... th gamma-secretase inhibitors.
@nl
prefLabel
Targeting presenilin-type aspa ...... th gamma-secretase inhibitors.
@en
Targeting presenilin-type aspa ...... th gamma-secretase inhibitors.
@nl
P2093
P356
P1476
Targeting presenilin-type aspa ...... th gamma-secretase inhibitors.
@en
P2093
Albert Schmitz
Andreas Weihofen
Bruno Martoglio
Elena Friedmann
Giorgio Rovelli
Heinrich Rueeger
Paolo Paganetti
P304
16528-16533
P356
10.1074/JBC.M301372200
P407
P577
2003-03-05T00:00:00Z