Mechanisms of nitric oxide independent activation of soluble guanylyl cyclase.
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NO-independent stimulators and activators of soluble guanylate cyclase: discovery and therapeutic potentialPDE-5 inhibition impedes TSP-1 expression, TGF-beta activation and matrix accumulation in experimental glomerulonephritis.Targeting soluble guanylate cyclase for the treatment of pulmonary hypertension.Pulmonary and systemic vasodilator responses to the soluble guanylyl cyclase stimulator, BAY 41-8543, are modulated by nitric oxide.cGMP-dependent protein kinases and cGMP phosphodiesterases in nitric oxide and cGMP action.Soluble guanylate cyclase as an emerging therapeutic target in cardiopulmonary disease.Soluble guanylate cyclase: a new therapeutic target for pulmonary arterial hypertension and chronic thromboembolic pulmonary hypertension.sGC{alpha}1 mediates the negative inotropic effects of NO in cardiac myocytes independent of changes in calcium handlingDynamic ligand exchange in soluble guanylyl cyclase (sGC): implications for sGC regulation and desensitization.Cobinamides are novel coactivators of nitric oxide receptor that target soluble guanylyl cyclase catalytic domain.Reduced vascular responses to soluble guanylyl cyclase but increased sensitivity to sildenafil in female rats with type 2 diabetes.Modulation of cGMP in heart failure: a new therapeutic paradigm.A Review of the Pathophysiology and Novel Treatments for Erectile Dysfunction.Guanylate cyclase activators, cell volume changes and IOP reduction.Stimulators and activators of soluble guanylate cyclase: review and potential therapeutic indications.Modulation of soluble guanylate cyclase for the treatment of erectile dysfunction.Structures of soluble guanylate cyclase: implications for regulatory mechanisms and drug development.New medical therapies for heart failure.Riociguat for the treatment of pulmonary hypertension.Activation of haem-oxidized soluble guanylyl cyclase with BAY 60-2770 in human platelets lead to overstimulation of the cyclic GMP signaling pathway.NO-independent stimulation or activation of soluble guanylyl cyclase during early reperfusion limits infarct size.Direct sGC activation bypasses NO scavenging reactions of intravascular free oxy-hemoglobin and limits vasoconstriction.Dynamic change of heme environment in soluble guanylate cyclase and complexation of NO-independent drug agents with H-NOX domain.Identification of residues crucially involved in the binding of the heme moiety of soluble guanylate cyclase.Kinetics of a cellular nitric oxide/cGMP/phosphodiesterase-5 pathway.Expression of inducible nitric oxide synthase messenger RNA, but not guanylate cyclase messenger RNA, depends on gestational age in rat myometrium.The soluble guanylate cyclase activator HMR1766 reverses hypoxia-induced experimental pulmonary hypertension in mice.Curcumin interacts with sildenafil to kill GI tumor cells via endoplasmic reticulum stress and reactive oxygen/ nitrogen species.An enzyme-linked receptor mechanism for nitric oxide-activated guanylyl cyclase.Vascular dysfunctions in the isolated aorta of double-transgenic hypertensive mice developing aortic aneurysm.
P2860
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P2860
Mechanisms of nitric oxide independent activation of soluble guanylyl cyclase.
description
2003 nî lūn-bûn
@nan
2003年の論文
@ja
2003年学术文章
@wuu
2003年学术文章
@zh
2003年学术文章
@zh-cn
2003年学术文章
@zh-hans
2003年学术文章
@zh-my
2003年学术文章
@zh-sg
2003年學術文章
@yue
2003年學術文章
@zh-hant
name
Mechanisms of nitric oxide independent activation of soluble guanylyl cyclase.
@en
Mechanisms of nitric oxide independent activation of soluble guanylyl cyclase.
@nl
type
label
Mechanisms of nitric oxide independent activation of soluble guanylyl cyclase.
@en
Mechanisms of nitric oxide independent activation of soluble guanylyl cyclase.
@nl
prefLabel
Mechanisms of nitric oxide independent activation of soluble guanylyl cyclase.
@en
Mechanisms of nitric oxide independent activation of soluble guanylyl cyclase.
@nl
P2093
P1476
Mechanisms of nitric oxide independent activation of soluble guanylyl cyclase.
@en
P2093
Henning Schröder
Matthias Schramm
Peter Schmidt
P304
P356
10.1016/S0014-2999(03)01674-1
P407
P577
2003-05-01T00:00:00Z