Identification of residues crucially involved in the binding of the heme moiety of soluble guanylate cyclase.
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NO-independent stimulators and activators of soluble guanylate cyclase: discovery and therapeutic potentialComparison of the properties of the five soluble guanylyl cyclase subunits in Drosophila melanogaster.Extending the translational potential of targeting NO/cGMP-regulated pathways in the CVSHemoglobin-mediated nitric oxide signalingNO and CO differentially activate soluble guanylyl cyclase via a heme pivot-bend mechanism.Structure of cinaciguat (BAY 58-2667) bound to Nostoc H-NOX domain reveals insights into heme-mimetic activation of the soluble guanylyl cyclase.Crystal structure of the Alpha subunit PAS domain from soluble guanylyl cyclaseInsights into Soluble Guanylyl Cyclase Activation Derived from Improved Heme-MimeticsIdentification of residues in the heme domain of soluble guanylyl cyclase that are important for basal and stimulated catalytic activityFluorescence dequenching makes haem-free soluble guanylate cyclase detectable in living cellsChronic Activation of Heme Free Guanylate Cyclase Leads to Renal Protection in Dahl Salt-Sensitive Rats.Multiple lineage specific expansions within the guanylyl cyclase gene familyNitric oxide scavenging by red blood cell microparticles and cell-free hemoglobin as a mechanism for the red cell storage lesion.The fibrate gemfibrozil is a NO- and haem-independent activator of soluble guanylyl cyclase: in vitro studies.Development of Therapeutics That Induce Mitochondrial Biogenesis for the Treatment of Acute and Chronic Degenerative Diseases.Targeting the heme-oxidized nitric oxide receptor for selective vasodilatation of diseased blood vesselsSoluble guanylate cyclase: a new therapeutic target for pulmonary arterial hypertension and chronic thromboembolic pulmonary hypertension.Oxidation and loss of heme in soluble guanylyl cyclase from Manduca sexta.Cinaciguat, a soluble guanylate cyclase activator, augments cGMP after oxidative stress and causes pulmonary vasodilation in neonatal pulmonary hypertension.Cobinamides are novel coactivators of nitric oxide receptor that target soluble guanylyl cyclase catalytic domain.Aspartate 102 in the heme domain of soluble guanylyl cyclase has a key role in NO activation.Cardiovascular and pharmacological implications of haem-deficient NO-unresponsive soluble guanylate cyclase knock-in mice.Primary response of the sGC heme binding domain to the cleavage of the Fe-His bond.Protoporphyrin IX/Cobyrinate Derived Hybrids - Novel Activators of Soluble Guanylyl CyclaseCloning, expression, purification, crystallization and preliminary X-ray diffraction analysis of hypothetical protein SCO4226 from Streptomyces coelicolor A3(2).Concepts of neural nitric oxide-mediated transmission.Heme deficiency of soluble guanylate cyclase induces gastroparesis.Modulation of cGMP in heart failure: a new therapeutic paradigm.Cinaciguat, a soluble guanylate cyclase activator, causes potent and sustained pulmonary vasodilation in the ovine fetus.Crystal structure of an oxygen-binding heme domain related to soluble guanylate cyclases.YC-1 binding to the β subunit of soluble guanylyl cyclase overcomes allosteric inhibition by the α subunit.Vascular dysfunction in cerebrovascular disease: mechanisms and therapeutic intervention.A Review of the Pathophysiology and Novel Treatments for Erectile Dysfunction.Guanylate cyclase activators, cell volume changes and IOP reduction.Stimulators and activators of soluble guanylate cyclase: review and potential therapeutic indications.Modulation of soluble guanylate cyclase for the treatment of erectile dysfunction.The chemistry and biology of soluble guanylate cyclase stimulators and activators.Nitric oxide-sensing H-NOX proteins govern bacterial communal behavior.NO-independent activation of soluble guanylate cyclase prevents disease progression in rats with 5/6 nephrectomy.Soluble Guanylate Cyclase Stimulators and Activators: Novel Therapies for Pulmonary Vascular Disease or a Different Method of Increasing cGMP?
P2860
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P2860
Identification of residues crucially involved in the binding of the heme moiety of soluble guanylate cyclase.
description
2003 nî lūn-bûn
@nan
2003年の論文
@ja
2003年学术文章
@wuu
2003年学术文章
@zh
2003年学术文章
@zh-cn
2003年学术文章
@zh-hans
2003年学术文章
@zh-my
2003年学术文章
@zh-sg
2003年學術文章
@yue
2003年學術文章
@zh-hant
name
Identification of residues cru ...... of soluble guanylate cyclase.
@en
Identification of residues cru ...... of soluble guanylate cyclase.
@nl
type
label
Identification of residues cru ...... of soluble guanylate cyclase.
@en
Identification of residues cru ...... of soluble guanylate cyclase.
@nl
prefLabel
Identification of residues cru ...... of soluble guanylate cyclase.
@en
Identification of residues cru ...... of soluble guanylate cyclase.
@nl
P2093
P2860
P356
P1476
Identification of residues cru ...... of soluble guanylate cyclase.
@en
P2093
Frank Wunder
Henning Schröder
Matthias Schramm
Peter M Schmidt
P2860
P304
P356
10.1074/JBC.M310141200
P407
P577
2003-10-21T00:00:00Z