Lysosomal and proteasomal degradation play distinct roles in the life cycle of Cx43 in gap junctional intercellular communication-deficient and -competent breast tumor cells.
about
Connexins: a myriad of functions extending beyond assembly of gap junction channelsNovel rab GAP-like protein, CIP85, interacts with connexin43 and induces its degradationUbiquitin-independent proteasomal degradation of endoplasmic reticulum-localized connexin43 mediated by CIP75Life cycle of connexins in health and diseasep53 downregulates its activating vaccinia-related kinase 1, forming a new autoregulatory loop7-Ketocholesterol modulates intercellular communication through gap-junction in bovine lens epithelial cellsGap junctionsAutophagy modulates dynamics of connexins at the plasma membrane in a ubiquitin-dependent mannerThe connexin43-interacting protein, CIP85, mediates the internalization of connexin43 from the plasma membrane.Internalization of large double-membrane intercellular vesicles by a clathrin-dependent endocytic process.Internalized gap junctions are degraded by autophagyA novel connexin43-interacting protein, CIP75, which belongs to the UbL-UBA protein family, regulates the turnover of connexin43.Monoclonal antibodies against the connexin43-interacting protein CIP85Mechanisms of gap junction traffic in health and diseaseDegradation of a connexin40 mutant linked to atrial fibrillation is accelerated.Autophagy: a pathway that contributes to connexin degradation.Connexin 31.1 degradation requires the Clathrin-mediated autophagy in NSCLC cell H1299.Cholesterol down-regulates BK channels stably expressed in HEK 293 cells.Investigation of the reciprocal relationship between the expression of two gap junction connexin proteins, connexin46 and connexin43.Myogenic bladder defects in mouse models of human oculodentodigital dysplasiaLatent transforming growth factor binding protein 4 regulates transforming growth factor beta receptor stability.The gap junction channel protein connexin 43 is covalently modified and regulated by SUMOylationMolecular mechanisms regulating formation, trafficking and processing of annular gap junctions.Mannose 6-Phosphate Receptor Is Reduced in -Synuclein Overexpressing Models of Parkinsons Disease.AMPK Suppresses Connexin43 Expression in the Bladder and Ameliorates Voiding Dysfunction in Cyclophosphamide-induced Mouse Cystitis.Degradation of gap junction connexins is regulated by the interaction with Cx43-interacting protein of 75 kDa (CIP75).O-Glycosylation of a Secretory Granule Membrane Enzyme Is Essential for Its Endocytic TraffickingA connexin50 mutant, CX50fs, that causes cataracts is unstable, but is rescued by a proteasomal inhibitor.Helicobacter pylori VacA induces apoptosis by accumulation of connexin 43 in autophagic vesicles via a Rac1/ERK-dependent pathway.Conformational maturation and post-ER multisubunit assembly of gap junction proteins.ERp29 restricts Connexin43 oligomerization in the endoplasmic reticulum.Neurological manifestations of oculodentodigital dysplasia: a Cx43 channelopathy of the central nervous system?Lens fiber connexin turnover and caspase-3-mediated cleavage are regulated alternately by phosphorylationReal-time imaging of sodium glucose transporter (SGLT1) trafficking and activity in single cellsConnexins: mechanisms regulating protein levels and intercellular communicationDegradation of connexins and gap junctions.Adrenergic control of cardiac gap junction function and expression.Degradation of connexins through the proteasomal, endolysosomal and phagolysosomal pathways.Degradation of endocytosed gap junctions by autophagosomal and endo-/lysosomal pathways: a perspectiveThe E3 ubiquitin ligase NEDD4 induces endocytosis and lysosomal sorting of connexin 43 to promote loss of gap junctions.
P2860
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P2860
Lysosomal and proteasomal degradation play distinct roles in the life cycle of Cx43 in gap junctional intercellular communication-deficient and -competent breast tumor cells.
description
2003 nî lūn-bûn
@nan
2003年の論文
@ja
2003年学术文章
@wuu
2003年学术文章
@zh
2003年学术文章
@zh-cn
2003年学术文章
@zh-hans
2003年学术文章
@zh-my
2003年学术文章
@zh-sg
2003年學術文章
@yue
2003年學術文章
@zh-hant
name
Lysosomal and proteasomal degr ...... -competent breast tumor cells.
@en
Lysosomal and proteasomal degr ...... -competent breast tumor cells.
@nl
type
label
Lysosomal and proteasomal degr ...... -competent breast tumor cells.
@en
Lysosomal and proteasomal degr ...... -competent breast tumor cells.
@nl
prefLabel
Lysosomal and proteasomal degr ...... -competent breast tumor cells.
@en
Lysosomal and proteasomal degr ...... -competent breast tumor cells.
@nl
P2093
P2860
P356
P1476
Lysosomal and proteasomal degr ...... -competent breast tumor cells.
@en
P2093
Moulay A Alaoui-Jamali
Suleiman A Igdoura
P2860
P304
30005-30014
P356
10.1074/JBC.M300614200
P407
P50
P577
2003-05-26T00:00:00Z