Mdm-2 and ubiquitin-independent p53 proteasomal degradation regulated by NQO1. - Wikidata - wikimedia - TriplyDB

Mdm-2 and ubiquitin-independent p53 proteasomal degradation regulated by NQO1.

Mdm-2 and ubiquitin-independent p53 proteasomal degradation regulated by NQO1.

http://www.wikidata.org/entity/Q34191852

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Proteasomal degradation of the KLF5 transcription factor through a ubiquitin-independent pathway Acetylation and phosphorylation of SRSF2 control cell fate decision in response to cisplatin Regulation of protein tyrosine kinase signaling by substrate degradation during brain development AIMP2/p38, the scaffold for the multi-tRNA synthetase complex, responds to genotoxic stresses via p53 Proteasomal Turnover of Hepatitis C Virus Core Protein Is Regulated by Two Distinct Mechanisms: a Ubiquitin-Dependent Mechanism and a Ubiquitin-Independent but PA28 -Dependent Mechanism Quercetin as an Emerging Anti-Melanoma Agent: A Four-Focus Area Therapeutic Development Strategy Redox-regulated turnover of Nrf2 is determined by at least two separate protein domains, the redox-sensitive Neh2 degron and the redox-insensitive Neh6 degron NAD(P)H:quinone acceptor oxidoreductase 1 (NQO1), a multifunctional antioxidant enzyme and exceptionally versatile cytoprotector The NQO1 polymorphism C609T (Pro187Ser) and cancer susceptibility: a comprehensive meta-analysis A mechanism of ubiquitin-independent proteasomal degradation of the tumor suppressors p53 and p73 Impairment of antioxidant defenses as a contributor to arsenite-induced cell transformation Fates of retroviral core components during unrestricted and TRIM5-restricted infection Rapid turnover of unspliced Xbp-1 as a factor that modulates the unfolded protein response p73 as a pharmaceutical target for cancer therapy TP63 and TP73 in cancer, an unresolved "family" puzzle of complexity, redundancy and hierarchy.NAD(P)H quinone-oxydoreductase 1 protects eukaryotic translation initiation factor 4GI from degradation by the proteasome.NAD(P)H quinone oxidoreductase protects TAp63gamma from proteasomal degradation and regulates TAp63gamma-dependent growth arrest.The pancreatic and duodenal homeobox protein PDX-1 regulates the ductal specific keratin 19 through the degradation of MEIS1 and DNA binding TP53, MDM2, NQO1, and susceptibility to cervical cancer.PIG3 Regulates p53 Stability by Suppressing Its MDM2-Mediated Ubiquitination Inhibition of NAD(P)H:quinone oxidoreductase 1 activity and induction of p53 degradation by the natural phenolic compound curcumin.A functional NQO1 609C>T polymorphism and risk of gastrointestinal cancers: a meta-analysis.Ubiquitin-dependent and ubiquitin-independent control of subunit stoichiometry in the SWI/SNF complex.P53 hot-spot mutants are resistant to ubiquitin-independent degradation by increased binding to NAD(P)H:quinone oxidoreductase 1 A functional NQO1 609C>T polymorphism and risk of hepatocellular carcinoma in a Chinese population.Proteasome-dependent, ubiquitin-independent degradation of the Rb family of tumor suppressors by the human cytomegalovirus pp71 protein Investigation of 3-aryl-pyrimido[5,4-e][1,2,4]triazine-5,7-diones as small molecule antagonists of β-catenin/TCF transcription.Inhibition of p53-induced apoptosis without affecting expression of p53-regulated genes.Hepatic transcriptomic profiling reveals early toxicological mechanisms of uranium in Atlantic salmon (Salmo salar)Two mutations impair the stability and function of ubiquitin-activating enzyme (E1)The NQO1*2/*2 polymorphism is associated with poor overall survival in patients following resection of stages II and IIIa non-small cell lung cancer.NQO1 Stabilizes p53 in Response to Oncogene-Induced Senescence.Germline SDHx variants modify breast and thyroid cancer risks in Cowden and Cowden-like syndrome via FAD/NAD-dependant destabilization of p53.Molecular Analysis of the HOXA2-Dependent Degradation of RCHY1.p53 mediates interstitial cystitis antiproliferative factor (APF)-induced growth inhibition of human urothelial cells Upregulation of NAD(P)H:quinone oxidoreductase by radiation potentiates the effect of bioreductive beta-lapachone on cancer cells.Inhibition of estrogen signaling activates the NRF2 pathway in breast cancer.The GTPase-deficient Rnd proteins are stabilized by their effectors.Ell3 stabilizes p53 following CDDP treatment via its effects on ubiquitin-dependent and -independent proteasomal degradation pathways in breast cancer cells APOBEC3G is degraded by the proteasomal pathway in a Vif-dependent manner without being polyubiquitylated.

P2860

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P2860

Mdm-2 and ubiquitin-independent p53 proteasomal degradation regulated by NQO1.

http://www.wikidata.org/entity/Q34191852

description

2002 nî lūn-bûn

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2002 թուականի Սեպտեմբերին հրատարակուած գիտական յօդուած

@hyw

2002 թվականի սեպտեմբերին հրատարակված գիտական հոդված

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2002年の論文

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2002年学术文章

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2002年学术文章

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2002年学术文章

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2002年学术文章

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2002年学术文章

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2002年學術文章

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name

Mdm-2 and ubiquitin-independent p53 proteasomal degradation regulated by NQO1.

@ast

Mdm-2 and ubiquitin-independent p53 proteasomal degradation regulated by NQO1.

@en

Mdm-2 and ubiquitin-independent p53 proteasomal degradation regulated by NQO1.

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type

label

Mdm-2 and ubiquitin-independent p53 proteasomal degradation regulated by NQO1.

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Mdm-2 and ubiquitin-independent p53 proteasomal degradation regulated by NQO1.

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Mdm-2 and ubiquitin-independent p53 proteasomal degradation regulated by NQO1.

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prefLabel

Mdm-2 and ubiquitin-independent p53 proteasomal degradation regulated by NQO1.

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Mdm-2 and ubiquitin-independent p53 proteasomal degradation regulated by NQO1.

@en

Mdm-2 and ubiquitin-independent p53 proteasomal degradation regulated by NQO1.

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Proceedings of the National Academy of Sciences of the United States of America

P1476

Mdm-2 and ubiquitin-independent p53 proteasomal degradation regulated by NQO1.

@en

P2093

Chaim Kahana

http://www.w3.org/2001/XMLSchema#string

Gad Asher

http://www.w3.org/2001/XMLSchema#string

Joseph Lotem

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Leo Sachs

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Yosef Shaul

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P2860

ARF promotes MDM2 degradation and stabilizes p53: ARF-INK4a locus deletion impairs both the Rb and p53 tumor suppression pathways

Mdm2 promotes the rapid degradation of p53

Regulation of p53 stability by Mdm2

The ubiquitin system

A system for stable expression of short interfering RNAs in mammalian cells

p53, the cellular gatekeeper for growth and division

Surfing the p53 network

Mdm2 binds p73 alpha without targeting degradation

Inhibition of MDM2 by hsp90 contributes to mutant p53 stabilization

Several hydrophobic amino acids in the p53 amino-terminal domain are required for transcriptional activation, binding to mdm-2 and the adenovirus 5 E1B 55-kD protein

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13125-13130

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10.1073/PNAS.202480499

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20

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99

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2002-09-13T00:00:00Z

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11158403

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12232053

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