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The microRNA-29 family in cartilage homeostasis and osteoarthritisExpression profiling of metalloproteinases and their inhibitors in cartilageThe comparative role of activator protein 1 and Smad factors in the regulation of Timp-1 and MMP-1 gene expression by transforming growth factor-beta 1The expression and function of microRNAs in chondrogenesis and osteoarthritis.The identification of trans-acting factors that regulate the expression of GDF5 via the osteoarthritis susceptibility SNP rs143383.Characterization of the cartilage DNA methylome in knee and hip osteoarthritisDetecting new microRNAs in human osteoarthritic chondrocytes identifies miR-3085 as a human, chondrocyte-selective, microRNA.Differential DNA methylation and expression of inflammatory and zinc transporter genes defines subgroups of osteoarthritic hip patientsA CD4 T cell gene signature for early rheumatoid arthritis implicates interleukin 6-mediated STAT3 signalling, particularly in anti-citrullinated peptide antibody-negative disease.Methylation quantitative trait locus analysis of osteoarthritis links epigenetics with genetic riskGenome-Wide MicroRNA and Gene Analysis of Mesenchymal Stem Cell Chondrogenesis Identifies an Essential Role and Multiple Targets for miR-140-5p.Proteinases involved in matrix turnover during cartilage and bone breakdown.Serum snoRNAs as biomarkers for joint ageing and post traumatic osteoarthritis.Epigenetic mechanisms in cartilage and osteoarthritis: DNA methylation, histone modifications and microRNAs.Epigenetic mechanisms and non-coding RNAs in osteoarthritis.cAMP response element-binding (CREB) recruitment following a specific CpG demethylation leads to the elevated expression of the matrix metalloproteinase 13 in human articular chondrocytes and osteoarthritis.MMP28 gene expression is regulated by Sp1 transcription factor acetylation.Oxidative changes and signalling pathways are pivotal in initiating age-related changes in articular cartilage.The first international workshop on the epigenetics of osteoarthritis.Protection against murine osteoarthritis by inhibition of the 26S proteasome and lysine-48 linked ubiquitination.Class I histone deacetylase inhibition modulates metalloproteinase expression and blocks cytokine-induced cartilage degradation.Matrix metalloproteinase 13 expression in response to double-stranded RNA in human chondrocytes.Expression of the osteoarthritis-associated gene GDF5 is modulated epigenetically by DNA methylation.Differential gene expression profiling of metalloproteinases and their inhibitors: a comparison between bovine intervertebral disc nucleus pulposus cells and articular chondrocytes.Activation of p38 and JNK MAPK pathways abrogates requirement for new protein synthesis for phorbol ester mediated induction of select MMP and TIMP genes.Rac upregulates tissue inhibitor of metalloproteinase-1 expression by redox-dependent activation of extracellular signal-regulated kinase signaling.Metalloproteinase and inhibitor expression profiling of resorbing cartilage reveals pro-collagenase activation as a critical step for collagenolysis.Lipophilic statins prevent matrix metalloproteinase-mediated cartilage collagen breakdown by inhibiting protein geranylgeranylation.Oncostatin M in combination with tumour necrosis factor {alpha} induces a chondrocyte membrane associated aggrecanase that is distinct from ADAMTS aggrecanase-1 or -2.Matriptase is a novel initiator of cartilage matrix degradation in osteoarthritis.HDAC-mediated control of ERK- and PI3K-dependent TGF-β-induced extracellular matrix-regulating genes.Editorial: More evidence for a role of CpG methylation in the pathogenesis of osteoarthritis.Synergistic collagenase expression and cartilage collagenolysis are phosphatidylinositol 3-kinase/Akt signaling-dependent.Pattern recognition receptor expression is not impaired in patients with chronic mucocutanous candidiasis with or without autoimmune polyendocrinopathy candidiasis ectodermal dystrophy.Mitochondrial dysfunction in osteoarthritis is associated with down-regulation of superoxide dismutase 2.The long non-coding RNA ROCR contributes to SOX9 expression and chondrogenic differentiation of human mesenchymal stem cells.Characterization of a gene encoding a single-subunit bacteriophage-type RNA polymerase from maize which is alternatively spliced.A negative feedback loop mediated by STAT3 limits human Th17 responses.An enhancer complex confers both high-level and cell-specific expression of the human type X collagen gene.Glycogen synthase kinase 3 inhibition stimulates human cartilage destruction and exacerbates murine osteoarthritis.
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P50
description
hulumtues
@sq
onderzoeker
@nl
researcher
@en
հետազոտող
@hy
name
David Alan Young
@ast
David Alan Young
@en
David Alan Young
@es
David Alan Young
@nl
David Alan Young
@sl
type
label
David Alan Young
@ast
David Alan Young
@en
David Alan Young
@es
David Alan Young
@nl
David Alan Young
@sl
prefLabel
David Alan Young
@ast
David Alan Young
@en
David Alan Young
@es
David Alan Young
@nl
David Alan Young
@sl
P106
P1153
55729215600
P21
P31
P496
0000-0002-7078-6745