Processive AID-catalysed cytosine deamination on single-stranded DNA simulates somatic hypermutation.
about
Transcription-coupled mutagenesis by the DNA deaminase AIDAID/APOBEC cytosine deaminase induces genome-wide kataegisHydroxylation of 5-methylcytosine by TET1 promotes active DNA demethylation in the adult brainGenetic editing of herpes simplex virus 1 and Epstein-Barr herpesvirus genomes by human APOBEC3 cytidine deaminases in culture and in vivoMutational comparison of the single-domained APOBEC3C and double-domained APOBEC3F/G anti-retroviral cytidine deaminases provides insight into their DNA target site specificitiesThe translesion DNA polymerase theta plays a dominant role in immunoglobulin gene somatic hypermutationMutational processes molding the genomes of 21 breast cancersRegulation of aicda expression and AID activity: relevance to somatic hypermutation and class switch DNA recombinationEssential role for DNA-PKcs in DNA double-strand break repair and apoptosis in ATM-deficient lymphocytesAlternative induction of meiotic recombination from single-base lesions of DNA deaminasesExpression of human AID in yeast induces mutations in context similar to the context of somatic hypermutation at G-C pairs in immunoglobulin genesMutational hotspots in the TP53 gene and, possibly, other tumor suppressors evolve by positive selection.Mutations, kataegis and translocations in B cells: understanding AID promiscuous activityTranscriptional stalling in B-lymphocytes: a mechanism for antibody diversification and maintenance of genomic integrityRelated Mechanisms of Antibody Somatic Hypermutation and Class Switch RecombinationActivation-induced deoxycytidine deaminase (AID) co-transcriptional scanning at single-molecule resolution.Insight into the HIV-1 Vif SOCS-box-ElonginBC interactionAID/APOBEC deaminases and cancerTGF-β triggers HBV cccDNA degradation through AID-dependent deaminationIsotype-switched follicular lymphoma displays dissociation between activation-induced cytidine deaminase expression and somatic hypermutationFlexibility in the order of action and in the enzymology of the nuclease, polymerases, and ligase of vertebrate non-homologous DNA end joining: relevance to cancer, aging, and the immune systemAPOBEC3A and APOBEC3B Preferentially Deaminate the Lagging Strand Template during DNA ReplicationActivation-induced cytidine deaminase deaminates 5-methylcytosine in DNA and is expressed in pluripotent tissues: implications for epigenetic reprogrammingShifts in targeting of class switch recombination sites in mice that lack mu switch region tandem repeats or Msh2Deletion of the nucleotide excision repair gene Ercc1 reduces immunoglobulin class switching and alters mutations near switch recombination junctionsSimultaneous in vitro characterisation of DNA deaminase function and associated DNA repair pathwaysGenome-wide mutation avalanches induced in diploid yeast cells by a base analog or an APOBEC deaminaseDisruption of Transcriptional Coactivator Sub1 Leads to Genome-Wide Re-distribution of Clustered Mutations Induced by APOBEC in Active Yeast GenesExamination of Msh6- and Msh3-deficient mice in class switching reveals overlapping and distinct roles of MutS homologues in antibody diversificationADAR1 protein induces adenosine-targeted DNA mutations in senescent Bcl6 gene-deficient cellsAnalysis of a single-stranded DNA-scanning process in which activation-induced deoxycytidine deaminase (AID) deaminates C to U haphazardly and inefficiently to ensure mutational diversityAID and Apobec3G haphazard deamination and mutational diversityEffects of prostaglandin E2 on p53 mRNA transcription and p53 mutagenesis during T-cell-independent human B-cell clonal expansionModelling mutational landscapes of human cancers in vitro.A Model of Somatic Hypermutation Targeting in Mice Based on High-Throughput Ig Sequencing Data.Activation-induced deaminase, AID, is catalytically active as a monomer on single-stranded DNA.Impact of phosphorylation and phosphorylation-null mutants on the activity and deamination specificity of activation-induced cytidine deaminase.Targeting of the activation-induced cytosine deaminase is strongly influenced by the sequence and structure of the targeted DNA.Haploinsufficiency of activation-induced deaminase for antibody diversification and chromosome translocations both in vitro and in vivo.Genetic evidence for single-strand lesions initiating Nbs1-dependent homologous recombination in diversification of Ig v in chicken B lymphocytes.
P2860
Q21194855-CAE34DB8-0BA8-48E7-8CF8-20C02009A41EQ21203746-D57CB162-DD1A-4A11-BF53-D175ACA22BD3Q24299862-AC7C7F27-4314-4B8D-BC60-22D69401AB68Q24305160-03908FF4-C0F8-4D9F-8A9E-5DAD4949615AQ24521469-64D54292-765B-4F6F-A0DB-C10BE6311E31Q24537096-06743948-E5E1-41DD-B7B1-078AD4194EA4Q24620915-504A027F-3CB8-4DFC-95FA-4FCB71A81274Q24633098-A0E27854-3DE9-47BA-8D80-F987D05F554BQ24649590-119F9006-1D3D-452B-9E38-BCC948B00D62Q24652699-162031F2-8F58-4EDF-87BC-9DDC06A6A0D0Q24814190-A4371E1D-22B4-4DFB-A25A-AFE74D8A9FBEQ25257243-E22C6219-C1E8-451C-A2AE-6751A6E12039Q26768663-79A61112-46FE-4E00-8971-EDD44A7F3E4FQ26862917-B3797C13-E751-4F67-BF28-08D14A1E6784Q27000758-EAB91843-4DD4-40E4-9606-07EC4308B2AFQ27337984-C6EC9985-F11D-406A-A8B0-D6DB14F8F266Q27680599-ACAFC579-98F2-4B7D-AF5E-82C8E32C3255Q28085553-1F67E788-F894-4761-8783-A51889272BBDQ28119132-4895D63E-44AA-4811-B4D3-EA9834F00757Q28260230-1724BDB4-B63C-4876-9EA4-D923E0862188Q28261381-9519234C-2D68-479C-92F9-2F12D3AA1A20Q28272805-E7A4BDF1-2967-453D-8F36-D4F528E10F35Q28284694-85409DA4-6312-4C4F-A964-F576C4C73AECQ28505280-9F2F6585-AB92-4F4B-A921-A3B6207B3480Q28508643-76057F6D-992F-4DD0-BBEA-7583715D6995Q28536559-9386E7B1-5E4C-4FEE-8F11-BF0BD5906065Q28536837-CDDD51CF-004A-48B3-95AB-EA34C3DA098DQ28547015-8764DD89-C6C9-4515-8833-AD18BD3B81A7Q28589828-8C8417EE-D671-4FBA-84BF-459E88605DF3Q28590572-34485714-4CD0-4735-8F2C-65642F2F0180Q30502490-B11EDD9C-9572-4F0B-B377-0C933052040CQ30537745-9C8A9CF6-310B-4FD3-AB45-DB629687F3E5Q30566367-C82DCE65-3D6C-4F93-9835-282A868020F3Q30836093-5AA326BD-FF0C-442B-98F5-E781E7F4BBBEQ31135078-F4F658BE-309C-46E1-BB01-C56B3E85A78EQ33299999-6B8205AB-58B9-446E-BFEA-FB827CD986E9Q33328760-25D53F21-00F1-4DD3-A2FF-4ABD56A18FEEQ33341846-3963E8D9-8572-425B-A0BA-A5652F391F4BQ33392701-A7C78F88-E0D5-4FBD-BEEE-75CC1BED942CQ33404063-29778FE2-B748-4A96-A10A-41D631B6BC64
P2860
Processive AID-catalysed cytosine deamination on single-stranded DNA simulates somatic hypermutation.
description
2003 nî lūn-bûn
@nan
2003年の論文
@ja
2003年学术文章
@wuu
2003年学术文章
@zh-cn
2003年学术文章
@zh-hans
2003年学术文章
@zh-my
2003年学术文章
@zh-sg
2003年學術文章
@yue
2003年學術文章
@zh
2003年學術文章
@zh-hant
name
Processive AID-catalysed cytos ...... mulates somatic hypermutation.
@en
Processive AID-catalysed cytos ...... mulates somatic hypermutation.
@nl
type
label
Processive AID-catalysed cytos ...... mulates somatic hypermutation.
@en
Processive AID-catalysed cytos ...... mulates somatic hypermutation.
@nl
prefLabel
Processive AID-catalysed cytos ...... mulates somatic hypermutation.
@en
Processive AID-catalysed cytos ...... mulates somatic hypermutation.
@nl
P2093
P356
P1433
P1476
Processive AID-catalysed cytos ...... mulates somatic hypermutation.
@en
P2093
John Petruska
Myron F Goodman
Phuong Pham
Ronda Bransteitter
P2888
P304
P356
10.1038/NATURE01760
P407
P577
2003-06-18T00:00:00Z
P6179
1003846875