Targeting of the activation-induced cytosine deaminase is strongly influenced by the sequence and structure of the targeted DNA.
about
The RNA exosome targets the AID cytidine deaminase to both strands of transcribed duplex DNA substratesTranscriptional stalling in B-lymphocytes: a mechanism for antibody diversification and maintenance of genomic integrityActivation-induced deoxycytidine deaminase (AID) co-transcriptional scanning at single-molecule resolution.Analysis of a single-stranded DNA-scanning process in which activation-induced deoxycytidine deaminase (AID) deaminates C to U haphazardly and inefficiently to ensure mutational diversityAID and Apobec3G haphazard deamination and mutational diversityImpact of phosphorylation and phosphorylation-null mutants on the activity and deamination specificity of activation-induced cytidine deaminase.Targeting of somatic hypermutation.The pattern of somatic hypermutation of Ig genes is altered when p53 is inactivated.Mechanism and regulation of class switch recombinationAIDing antibody diversity by error-prone mismatch repair.Detection of chromatin-associated single-stranded DNA in regions targeted for somatic hypermutation.Single-stranded DNA structure and positional context of the target cytidine determine the enzymatic efficiency of AID.Alkyladenine DNA glycosylase (Aag) in somatic hypermutation and class switch recombinationRegulation of activation-induced cytidine deaminase DNA deamination activity in B-cells by Ser38 phosphorylation.Changes in RNA polymerase II progression influence somatic hypermutation of Ig-related genes by AIDTranscriptional pausing and stalling causes multiple clustered mutations by human activation-induced deaminase.Interference of mismatch and base excision repair during the processing of adjacent U/G mispairs may play a key role in somatic hypermutationImmunoglobulin class switch recombination: study through human natural mutantsA mathematical model for scanning and catalysis on single-stranded DNA, illustrated with activation-induced deoxycytidine deaminaseThe activation-induced cytidine deaminase (AID) efficiently targets DNA in nucleosomes but only during transcription.Post-translational regulation of activation-induced cytidine deaminase.Histone H3.3 promotes IgV gene diversification by enhancing formation of AID-accessible single-stranded DNA.Nucleosome stability dramatically impacts the targeting of somatic hypermutation.The transcription elongation complex directs activation-induced cytidine deaminase-mediated DNA deamination.AID associates with single-stranded DNA with high affinity and a long complex half-life in a sequence-independent manner.The in vivo pattern of AID targeting to immunoglobulin switch regions deduced from mutation spectra in msh2-/- ung-/- miceHypermutation at A/T sites during G.U mismatch repair in vitro by human B-cell lysates.Stabilised DNA secondary structures with increasing transcription localise hypermutable bases for somatic hypermutation in IGHV3-23.Effects of sodium cationization versus protonation on the conformations and N-glycosidic bond stabilities of sodium cationized Urd and dUrd: solution conformation of [Urd+Na]+ is preserved upon ESI.
P2860
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P2860
Targeting of the activation-induced cytosine deaminase is strongly influenced by the sequence and structure of the targeted DNA.
description
2005 nî lūn-bûn
@nan
2005 թուականի Դեկտեմբերին հրատարակուած գիտական յօդուած
@hyw
2005 թվականի դեկտեմբերին հրատարակված գիտական հոդված
@hy
2005年の論文
@ja
2005年論文
@yue
2005年論文
@zh-hant
2005年論文
@zh-hk
2005年論文
@zh-mo
2005年論文
@zh-tw
2005年论文
@wuu
name
Targeting of the activation-in ...... structure of the targeted DNA.
@ast
Targeting of the activation-in ...... structure of the targeted DNA.
@en
type
label
Targeting of the activation-in ...... structure of the targeted DNA.
@ast
Targeting of the activation-in ...... structure of the targeted DNA.
@en
prefLabel
Targeting of the activation-in ...... structure of the targeted DNA.
@ast
Targeting of the activation-in ...... structure of the targeted DNA.
@en
P2093
P2860
P1476
Targeting of the activation-in ...... structure of the targeted DNA.
@en
P2093
Hong Ming Shen
Sarayu Ratnam
Ursula Storb
P2860
P304
10815-10821
P356
10.1128/MCB.25.24.10815-10821.2005
P407
P577
2005-12-01T00:00:00Z