Elucidation of a novel epitope of a substrate-inducing monoclonal antibody against the serpin PAI-1.

about

An antibody that prevents serpin polymerisation acts by inducing a novel allosteric behaviour.Site-directed targeting of plasminogen activator inhibitor-1 as an example for a novel approach in rational drug design.

P2860

Q37605015-E539B438-4F90-4254-9935-D26DF80E8A0B Q44779421-9127EAA3-BA79-4641-A8E0-A8B841EFB0A6

P2860

Elucidation of a novel epitope of a substrate-inducing monoclonal antibody against the serpin PAI-1.

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http://www.wikidata.org/entity/Q44518810

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2003 nî lūn-bûn

@nan

2003年の論文

@ja

2003年学术文章

@wuu

2003年学术文章

@zh

2003年学术文章

@zh-cn

2003年学术文章

@zh-hans

2003年学术文章

@zh-my

2003年学术文章

@zh-sg

2003年學術文章

@yue

2003年學術文章

@zh-hant

name

Elucidation of a novel epitope ...... body against the serpin PAI-1.

@en

Elucidation of a novel epitope ...... body against the serpin PAI-1.

@nl

type

Item

label

Elucidation of a novel epitope ...... body against the serpin PAI-1.

@en

Elucidation of a novel epitope ...... body against the serpin PAI-1.

@nl

prefLabel

Elucidation of a novel epitope ...... body against the serpin PAI-1.

@en

Elucidation of a novel epitope ...... body against the serpin PAI-1.

@nl

P1476

Elucidation of a novel epitope ...... body against the serpin PAI-1.

@en

P2093

Compernolle G

http://www.w3.org/2001/XMLSchema#string

Gils A

http://www.w3.org/2001/XMLSchema#string

Naessens D

http://www.w3.org/2001/XMLSchema#string

P2860

Structure of a serpin-protease complex shows inhibition by deformation

Plasminogen activator inhibitor 1. Structure of the native serpin, comparison to its other conformers and implications for serpin inactivation

The structure of a Michaelis serpin-protease complex

A serpin-induced extensive proteolytic susceptibility of urokinase-type plasminogen activator implicates distortion of the proteinase substrate-binding pocket and oxyanion hole in the serpin inhibitory mechanism.

Epitope mapping for four monoclonal antibodies against human plasminogen activator inhibitor type-1: implications for antibody-mediated PAI-1-neutralization and vitronectin-binding.

Interconversions between active, inert and substrate forms of denatured/refolded type-1 plasminogen activator inhibitor.

A regulatory hydrophobic area in the flexible joint region of plasminogen activator inhibitor-1, defined with fluorescent activity-neutralizing ligands. Ligand-induced serpin polymerization.

The distal hinge of the reactive site loop and its proximity: a target to modulate plasminogen activator inhibitor-1 activity.

Mechanisms of conversion of plasminogen activator inhibitor 1 from a suicide inhibitor to a substrate by monoclonal antibodies.

Inhibition of plasminogen activator inhibitor-1 activity results in promotion of endogenous thrombolysis and inhibition of thrombus extension in models of experimental thrombosis.

P304

1028-1033

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P31

scholarly article

P356

10.1046/J.1538-7836.2003.00206.X

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P433

http://www.w3.org/2001/XMLSchema#string

P478

http://www.w3.org/2001/XMLSchema#string

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Paul Declerck

P577

2003-05-01T00:00:00Z

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P5875

6526273

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P698

12871373

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Elucidation of a novel epitope of a substrate-inducing monoclonal antibody against the serpin PAI-1.

about

P2860

P2860

Elucidation of a novel epitope of a substrate-inducing monoclonal antibody against the serpin PAI-1.

description

name

type

label

prefLabel

P1433

P1476

P2093

P2860

P304

P31

P356

P433

P478

P50

P577

P5875

P698

P356

P1433

P1476

P2093

P2860

P304

P31

P356

P433

P478

P50

P577

P5875

P698