The Lyn tyrosine kinase negatively regulates neutrophil integrin signaling.
about
Integrin inhibition through Lyn-dependent cross talk from CXCR4 chemokine receptors in normal human CD34+ marrow cellsThe kinase Btk negatively regulates the production of reactive oxygen species and stimulation-induced apoptosis in human neutrophilsImpaired integrin-dependent function in Wiskott-Aldrich syndrome protein-deficient murine and human neutrophils.Neutrophil-specific deletion of Syk kinase results in reduced host defense to bacterial infectionThe non-receptor tyrosine kinase Lyn controls neutrophil adhesion by recruiting the CrkL-C3G complex and activating Rap1 at the leading edgeShp1 signalling is required to establish the long-lived bone marrow plasma cell pool.Myeloid cells, BAFF, and IFN-gamma establish an inflammatory loop that exacerbates autoimmunity in Lyn-deficient mice.Rab27a and Rab27b regulate neutrophil azurophilic granule exocytosis and NADPH oxidase activity by independent mechanisms.Lyn is a redox sensor that mediates leukocyte wound attraction in vivo.A dual activation and inhibition role for the paired immunoglobulin-like receptor B in eosinophilsIdentification of phosphoproteins associated with human neutrophil granules following chemotactic peptide stimulation.Separate checkpoints regulate splenic plasma cell accumulation and IgG autoantibody production in Lyn-deficient miceReal-time analysis of imatinib- and dasatinib-induced effects on chronic myelogenous leukemia cell interaction with fibronectin.B cell-derived IL-10 suppresses inflammatory disease in Lyn-deficient mice.Transmigration of neutrophils across inflamed endothelium is signaled through LFA-1 and Src family kinase.Strain-dependent induction of neutrophil histamine production and cell death by Pseudomonas aeruginosa.The actin regulatory protein HS1 interacts with Arp2/3 and mediates efficient neutrophil chemotaxis.Paired immunoglobulin-like receptors and their MHC class I recognition.Neutrophil histamine contributes to inflammation in mycoplasma pneumonia.Distinct roles for neutrophils and dendritic cells in inflammation and autoimmunity in motheaten miceConvergence of immunoreceptor and integrin signaling.The Src family kinase, Lyn, suppresses osteoclastogenesis in vitro and in vivoThe diverse functions of Src family kinases in macrophages.The absence of Hck, Fgr, and Lyn tyrosine kinases augments lung innate immune responses to Pneumocystis murina.A critical role for Lyn kinase in strengthening endothelial integrity and barrier function.Multiple roles of Lyn kinase in myeloid cell signaling and function.PTPN22 Is a Critical Regulator of Fcγ Receptor-Mediated Neutrophil ActivationBruton tyrosine kinase (BTK) and its role in B-cell malignancy.Neutrophil migration: moving from zebrafish models to human autoimmunity.Increased survival and reduced neutrophil infiltration of the liver in Rab27a- but not Munc13-4-deficient mice in lipopolysaccharide-induced systemic inflammation.Myeloid Populations in Systemic Autoimmune Diseases.Interleukin-33 requires CMRF35-like molecule-1 expression for induction of myeloid cell activation.-NOD Mice Having a Lyn Tyrosine Kinase Mutation Exhibit Abnormal Neutrophil Chemotaxis.Neutrophils to the ROScue: Mechanisms of NADPH Oxidase Activation and Bacterial Resistance.Role of protein tyrosine kinase p53/56lyn in diminished lipopolysaccharide priming of formylmethionylleucyl- phenylalanine-induced superoxide production in human newborn neutrophils.Early tyrosine phosphorylation events following adenosine A2A receptor in human neutrophils: identification of regulated pathways.Role of CD47 and Signal Regulatory Protein Alpha (SIRPα) in Regulating the Clearance of Viable or Aged Blood Cells.Role of negative regulation of immune signaling pathways in neutrophil function.Lyn, one of the Src-family tyrosine kinases expressed in phagocytes, plays an important role in beta2 integrin-signalling pathways in opsonized zymosan-activated macrophage-like U937 cells.Lyn prevents aberrant inflammatory responses to infection in mammalian systems by repressing a SHIP-1-associated signaling cluster
P2860
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P2860
The Lyn tyrosine kinase negatively regulates neutrophil integrin signaling.
description
2003 nî lūn-bûn
@nan
2003年の論文
@ja
2003年学术文章
@wuu
2003年学术文章
@zh
2003年学术文章
@zh-cn
2003年学术文章
@zh-hans
2003年学术文章
@zh-my
2003年学术文章
@zh-sg
2003年學術文章
@yue
2003年學術文章
@zh-hant
name
The Lyn tyrosine kinase negatively regulates neutrophil integrin signaling.
@en
The Lyn tyrosine kinase negatively regulates neutrophil integrin signaling.
@nl
type
label
The Lyn tyrosine kinase negatively regulates neutrophil integrin signaling.
@en
The Lyn tyrosine kinase negatively regulates neutrophil integrin signaling.
@nl
prefLabel
The Lyn tyrosine kinase negatively regulates neutrophil integrin signaling.
@en
The Lyn tyrosine kinase negatively regulates neutrophil integrin signaling.
@nl
P1476
The Lyn tyrosine kinase negatively regulates neutrophil integrin signaling.
@en
P2093
Clifford Lowell
Shalini Pereira
P304
P356
10.4049/JIMMUNOL.171.3.1319
P407
P577
2003-08-01T00:00:00Z