Myeloid cells, BAFF, and IFN-gamma establish an inflammatory loop that exacerbates autoimmunity in Lyn-deficient mice. - Wikidata - wikimedia - TriplyDB

Myeloid cells, BAFF, and IFN-gamma establish an inflammatory loop that exacerbates autoimmunity in Lyn-deficient mice.

Myeloid cells, BAFF, and IFN-gamma establish an inflammatory loop that exacerbates autoimmunity in Lyn-deficient mice.

http://www.wikidata.org/entity/Q34044394

about

Defects in Germinal Center Selection in SLE The rationale for BAFF inhibition in systemic lupus erythematosus Contribution of Toll-like receptor signaling to germinal center antibody responses Pathogenic Inflammation and Its Therapeutic Targeting in Systemic Lupus Erythematosus BAFF regulates follicular helper t cells and affects their accumulation and interferon-γ production in autoimmunity.Neutrophils contribute to excess serum BAFF levels and promote CD4+ T cell and B cell responses in lupus-prone mice.B cell maturation antigen deficiency exacerbates lymphoproliferation and autoimmunity in murine lupus Pathways leading to an immunological disease: systemic lupus erythematosus.The function of BAFF on T helper cells in autoimmunity Requirement for MyD88 signaling in B cells and dendritic cells for germinal center anti-nuclear antibody production in Lyn-deficient mice Increased levels of BAFF and APRIL related to human active pulmonary tuberculosis.Complement opsonization of HIV-1 results in decreased antiviral and inflammatory responses in immature dendritic cells via CR3 Murine models of systemic lupus erythematosus Innate immune programing by endotoxin and its pathological consequences IFN-γ production by memory helper T cells is required for CD40-independent alloantibody responses.BAFF knockout improves systemic inflammation via regulating adipose tissue distribution in high-fat diet-induced obesity.CD8+ T cells regulate bone tumor burden independent of osteoclast resorption.IFN-α confers resistance of systemic lupus erythematosus nephritis to therapy in NZB/W F1 mice IFN-β treatment requires B cells for efficacy in neuroautoimmunity.Deletion of Syk in neutrophils prevents immune complex arthritis B cell-derived IL-10 suppresses inflammatory disease in Lyn-deficient mice.PRKDC mutations associated with immunodeficiency, granuloma, and autoimmune regulator-dependent autoimmunity.Unbiased modifier screen reveals that signal strength determines the regulatory role murine TLR9 plays in autoantibody production.The B Cell-Stimulatory Cytokines BLyS and APRIL Are Elevated in Human Periodontitis and Are Required for B Cell-Dependent Bone Loss in Experimental Murine Periodontitis.Genetic Interaction between Lyn, Ets1, and Btk in the Control of Antibody Levels.B Cell-Activating Factor. An Orchestrator of Lymphoid Follicles in Severe Chronic Obstructive Pulmonary Disease.Functions of the Lyn tyrosine kinase in health and disease Lyn deficiency affects B-cell maturation as well as survival Elevated BCR signaling and decreased survival of Lyn-deficient transitional and follicular B cells.B-cell activating factor targeted therapy and lupus.The structural wedge domain of the receptor-like tyrosine phosphatase CD45 enforces B cell tolerance by regulating substrate specificity.Neutrophils in animal models of autoimmune disease Immune Defense Protein Expression in Highly Purified Mouse Lung Epithelial Cells.Genetic susceptibility to lupus: the biological basis of genetic risk found in B cell signaling pathways.Hyperactivated MyD88 signaling in dendritic cells, through specific deletion of Lyn kinase, causes severe autoimmunity and inflammation IL-21 promotes the production of anti-DNA IgG but is dispensable for kidney damage in lyn-/- mice.The effect of BAFF inhibition on autoreactive B cell selection in murine SLE.LYN- and AIRE-mediated tolerance checkpoint defects synergize to trigger organ-specific autoimmunity.B cell-specific loss of Lyn kinase leads to autoimmunity Post-transplantation B cell activating factor and B cell recovery before onset of chronic graft-versus-host disease.

P2860

Q26796041-55568032-18BC-45B1-846A-4CBD5CD43830 Q26827373-B0BB96B2-6C56-424D-BEC1-AC056F8F8A96 Q26829061-4DDAC2A6-B26E-4694-9BCE-482F3248C600 Q28088753-C65A1221-25FD-4C7A-B4A6-E46F4B5D9F4D Q30360393-B8AC1354-F2D9-488A-888B-1834EFF1AD8E Q30411860-43574555-F25B-4463-88D5-57C358AD19B8 Q30426692-6C49E35C-ADFD-479C-8FF7-67C9184F2F20 Q33620555-B8875716-4367-4865-A2BA-E2CD859CC696 Q33748041-14F8229A-F0FF-469A-8D2D-6A986FC6272D Q33911256-1C5B0505-4440-4CDA-96BA-D1946018BD6A Q34311903-AF443E29-E937-4EC3-AF66-3E97D0E77A6C Q34364911-B74039C0-BA9A-4B72-B8F9-AAD85A8B68A3 Q34591019-171FFCB4-1827-4C0D-8CD7-23B48C7F9921 Q34841012-834857F6-F03E-49BA-99EF-2EA524191AD7 Q34980154-5BC7832C-4FF7-4E3A-A554-88DA026298BB Q35040658-2659F2D1-7431-47F6-BCFB-2CD8D9053449 Q35112793-34D4FE24-98DD-49C7-8B9A-EA58DCF91A2C Q35118781-F0D24503-3CD5-4BDA-A85F-197F7E82860B Q35122216-EE2E9895-65F3-4EEE-A9A1-00076C3EB4FF Q35269028-5A6893A2-7285-4280-8A68-90A6178A76C0 Q35345025-EB2C850F-4CE2-42BA-8752-E97D286983F8 Q35806314-63DC54A9-A672-4FC5-8DAB-10F430065777 Q35854962-B9050E1B-85A7-421F-BE7C-B9BD0290810B Q35931503-E46DCA73-5F4E-492D-A4CB-73BD31B80374 Q35988682-510FD095-BB80-4F12-8D2D-B55D3CC903FC Q36128542-EE79FE65-9F26-4167-8F44-91B925D2D447 Q36299576-0BE2D557-49B8-4E0A-9759-B250DE9FF8A8 Q36452396-B796E3FF-CE24-40F7-ACA7-DBC39E1073E8 Q36453064-BF22809F-4580-45F5-97F1-F5B180EBC47B Q36504641-0B9B7552-53FE-453C-B0D1-5A1BD5D78DA7 Q36672815-3B282F55-2A6F-4FB8-9C58-683C115E5688 Q36902110-DA2CEA6A-3900-43FF-8A54-0706B2C26BCC Q37088320-CFB27F5A-C45C-4A28-B15A-15060B094ABE Q37107525-29D8E5B8-7E40-4B77-A2D7-697714BA6003 Q37143577-EB6BE747-ED2F-477A-86B3-CB65E76F095F Q37158607-7536E032-FFD4-4202-8519-33F700D691FA Q37217047-3D04FF74-B69D-47BB-A416-5E7B6431ED74 Q37381383-E9B24E95-727A-4F70-8F0C-4E76EA5967A5 Q37509056-FC75ABF0-93B2-48F4-8D3C-46F920951472 Q37700864-BAD7A489-B583-4DF5-A759-E76F9D330DC4

P2860

Myeloid cells, BAFF, and IFN-gamma establish an inflammatory loop that exacerbates autoimmunity in Lyn-deficient mice.

http://www.wikidata.org/entity/Q34044394

description

2010 nî lūn-bûn

@nan

2010 թուականի Յուլիսին հրատարակուած գիտական յօդուած

@hyw

2010 թվականի հուլիսին հրատարակված գիտական հոդված

@hy

2010年の論文

@ja

2010年論文

@yue

2010年論文

@zh-hant

2010年論文

@zh-hk

2010年論文

@zh-mo

2010年論文

@zh-tw

2010年论文

@wuu

name

Myeloid cells, BAFF, and IFN-g ...... mmunity in Lyn-deficient mice.

@ast

Myeloid cells, BAFF, and IFN-g ...... mmunity in Lyn-deficient mice.

@en

Myeloid cells, BAFF, and IFN-g ...... mmunity in Lyn-deficient mice.

@nl

type

label

Myeloid cells, BAFF, and IFN-g ...... mmunity in Lyn-deficient mice.

@ast

Myeloid cells, BAFF, and IFN-g ...... mmunity in Lyn-deficient mice.

@en

Myeloid cells, BAFF, and IFN-g ...... mmunity in Lyn-deficient mice.

@nl

prefLabel

Myeloid cells, BAFF, and IFN-g ...... mmunity in Lyn-deficient mice.

@ast

Myeloid cells, BAFF, and IFN-g ...... mmunity in Lyn-deficient mice.

@en

Myeloid cells, BAFF, and IFN-g ...... mmunity in Lyn-deficient mice.

@nl

P1433

Q34044394-06F7F201-A8B6-4A27-8759-CEF5DF60324B

P1476

Q34044394-7619ED13-BC81-4552-87BF-51CE7464D970

P2093

Q34044394-114DF13D-52CF-4DFD-989E-FBB2D60FF6BD

Q34044394-3E70E5BF-DEB4-4958-A2B9-56A98132467F

Q34044394-58F09E03-0811-40C6-BD52-0B33A71E620C

Q34044394-8AFC26F0-6077-4303-8EB5-9F2B011DC65A

Q34044394-C9663FFC-1C55-4DDC-83D6-13FF39281EF4

Q34044394-FEFE832D-B878-423B-9D21-525429DE5C87

Q34044394-FF267A4E-8659-4F25-95A3-1EFE69F60C36

P2860

Q34044394-074824C3-9371-468C-B2B5-6A6F9E93D709

Q34044394-07E34551-15E3-4D15-BEEA-3B054F48E966

Q34044394-0A456C0B-3AD4-40FC-8B7D-68826339A229

Q34044394-12131701-CE1A-45F7-A3E2-D2D8C09E483D

Q34044394-1CBC5E77-4A1B-4441-BA8B-C6A60E5EDAE9

Q34044394-1E7BB377-F018-454A-9EB9-3C8CEE9B1E9F

Q34044394-215D6B79-A2BF-4842-84F0-536B26F21296

Q34044394-2637A9C0-5244-4B47-8B00-B5F7353B615D

Q34044394-278B0C82-FD4E-4CE7-87BB-B94F590BD2A3

Q34044394-2F8B4155-F2CB-4E74-8438-FB3C61D0DAFA

P304

Q34044394-C0E946B0-BF73-4B5E-AD80-825C9DB590CB

P31

Q34044394-B7E6CA81-D13B-4EC2-9870-D70771036AA9

P356

Q34044394-4419CF44-1651-4EAF-951C-E2B7827732AD

P407

Q34044394-F863A1BB-FA8C-4A26-9835-311B75BE749F

P433

Q34044394-C6957A00-A246-4657-A851-28E16D238CAD

P478

Q34044394-57E85FB8-27DA-4976-9527-3A5CCAB797E3

P577

Q34044394-156C9285-A6FF-4DD2-967D-6B21699F87BA

P5875

Q34044394-3A9D0B5F-53B8-49E7-A18E-4BB87BAE9EC0

P698

Q34044394-082D6BD5-8FC0-486C-A2A2-E78635EEC7D9

P932

Q34044394-A31E122D-D5D2-4601-BA30-C4070726CFB0

P356

P1433

Journal of Experimental Medicine

P1476

Myeloid cells, BAFF, and IFN-g ...... mmunity in Lyn-deficient mice.

@en

P2093

Anthony L Defranco

http://www.w3.org/2001/XMLSchema#string

Ching-Liang Chu

http://www.w3.org/2001/XMLSchema#string

Clifford A Lowell

http://www.w3.org/2001/XMLSchema#string

Marco A Cassatella

http://www.w3.org/2001/XMLSchema#string

Patrizia Scapini

http://www.w3.org/2001/XMLSchema#string

Thi-Sau Migone

http://www.w3.org/2001/XMLSchema#string

Yongmei Hu

http://www.w3.org/2001/XMLSchema#string

P2860

The role of IFN-gamma in systemic lupus erythematosus: a challenge to the Th1/Th2 paradigm in autoimmunity.

Gain- and loss-of-function Lyn mutant mice define a critical inhibitory role for Lyn in the myeloid lineage

The role of APRIL and BAFF in lymphocyte activation

The role of the BAFF/APRIL system on T cell function

Src-family kinases: rheostats of immune cell signaling

Defective negative regulation of antigen receptor signaling in Lyn-deficient B lymphocytes

Lyn tyrosine kinase: accentuating the positive and the negative

BAFF binding to T cell-expressed BAFF-R costimulates T cell proliferation and alloresponses

Characterization of the B lymphocyte populations in Lyn-deficient mice and the role of Lyn in signal initiation and down-regulation

Integrin signaling in neutrophils and macrophages uses adaptors containing immunoreceptor tyrosine-based activation motifs

P304

1757-1773

http://www.w3.org/2001/XMLSchema#string

P31

scholarly article

P356

10.1084/JEM.20100086

http://www.w3.org/2001/XMLSchema#string

P407

P433

8

http://www.w3.org/2001/XMLSchema#string

P478

207

http://www.w3.org/2001/XMLSchema#string

P577

2010-07-12T00:00:00Z

http://www.w3.org/2001/XMLSchema#dateTime

P5875

45167288

http://www.w3.org/2001/XMLSchema#string

P698

20624892

http://www.w3.org/2001/XMLSchema#string

P932

2916124

http://www.w3.org/2001/XMLSchema#string