IRAK-4 kinase activity is required for IRAK-4-dependent innate and adaptive immune responses.
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IRAK-4 inhibitors for inflammationStructural dynamic analysis of apo and ATP-bound IRAK4 kinaseMicroRNA-302b augments host defense to bacteria by regulating inflammatory responses via feedback to TLR/IRAK4 circuits.Differential role for c-Rel and C/EBPbeta/delta in TLR-mediated induction of proinflammatory cytokines.Impaired T-cell receptor activation in IL-1 receptor-associated kinase-4-deficient patients.IL-1 enhances expansion, effector function, tissue localization, and memory response of antigen-specific CD8 T cellsLinks between Toll-like receptor 4 and breast cancerIRAK4 kinase activity is not required for induction of endotoxin tolerance but contributes to TLR2-mediated toleranceMAP kinase phosphatase-1, a critical negative regulator of the innate immune response.Suppressors of cytokine signaling (SOCS) in T cell differentiation, maturation, and function.Inhibition of the type I interferon antiviral response during arenavirus infection.Induction of endotoxin tolerance in vivo inhibits activation of IRAK4 and increases negative regulators IRAK-M, SHIP-1, and A20.Deficiency in IRAK4 activity attenuates manifestations of murine Lupus.Interleukin-1 receptor-associated kinase 4 is essential for initial host control of Brucella abortus infection.Complete dependence on IRAK4 kinase activity in TLR2, but not TLR4, signaling pathways underlies decreased cytokine production and increased susceptibility to Streptococcus pneumoniae infection in IRAK4 kinase-inactive miceB cell antigen receptor-induced activation of an IRAK4-dependent signaling pathway revealed by a MALT1-IRAK4 double knockout mouse model.Interleukin-1R signaling is essential for induction of proapoptotic CD8 T cells, viral clearance, and pathology during lymphocytic choriomeningitis virus infection in mice.
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P2860
IRAK-4 kinase activity is required for IRAK-4-dependent innate and adaptive immune responses.
description
2008 nî lūn-bûn
@nan
2008年の論文
@ja
2008年学术文章
@wuu
2008年学术文章
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2008年学术文章
@zh-cn
2008年学术文章
@zh-hans
2008年学术文章
@zh-my
2008年学术文章
@zh-sg
2008年學術文章
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2008年學術文章
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name
IRAK-4 kinase activity is requ ...... and adaptive immune responses.
@en
IRAK-4 kinase activity is requ ...... and adaptive immune responses.
@nl
type
label
IRAK-4 kinase activity is requ ...... and adaptive immune responses.
@en
IRAK-4 kinase activity is requ ...... and adaptive immune responses.
@nl
prefLabel
IRAK-4 kinase activity is requ ...... and adaptive immune responses.
@en
IRAK-4 kinase activity is requ ...... and adaptive immune responses.
@nl
P2093
P2860
P356
P1476
IRAK-4 kinase activity is requ ...... and adaptive immune responses
@en
P2093
Alisha R Elford
Elizabeth Lye
Salim Dhanji
P2860
P304
P356
10.1002/EJI.200737429
P407
P577
2008-03-01T00:00:00Z