Simvastatin-mediated upregulation of VEGF and BDNF, activation of the PI3K/Akt pathway, and increase of neurogenesis are associated with therapeutic improvement after traumatic brain injury.
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Neuroprotection for traumatic brain injuryGenetic manipulation of cell death and neuroplasticity pathways in traumatic brain injuryIron behaving badly: inappropriate iron chelation as a major contributor to the aetiology of vascular and other progressive inflammatory and degenerative diseasesEffects of AMP-activated protein kinase in cerebral ischemiaSubacute intranasal administration of tissue plasminogen activator promotes neuroplasticity and improves functional recovery following traumatic brain injury in ratsA small molecule p75(NTR) ligand protects neurogenesis after traumatic brain injuryAtorvastatin enhances neurite outgrowth in cortical neurons in vitro via up-regulating the Akt/mTOR and Akt/GSK-3β signaling pathwaysNicotinamide forestalls pathology and cognitive decline in Alzheimer mice: evidence for improved neuronal bioenergetics and autophagy procession.Statin treatment in multiple sclerosis: a systematic review and meta-analysis.Inhibition of PI3K-Akt signaling blocks exercise-mediated enhancement of adult neurogenesis and synaptic plasticity in the dentate gyrusFarnesyl pyrophosphate inhibits epithelialization and wound healing through the glucocorticoid receptorAnalysis of neurotrophins in human serum by immunoaffinity capillary electrophoresis (ICE) following traumatic head injurySimvastatin enhances hippocampal long-term potentiation in C57BL/6 mice.Erythropoietin improves histological and functional outcomes after traumatic brain injury in mice in the absence of the neural erythropoietin receptor.Role of Akt-independent mTORC1 and GSK3β signaling in sublethal NMDA-induced injury and the recovery of neuronal electrophysiology and survivalAngiogenesis, neurogenesis and brain recovery of function following injuryImpact of statins on cognitive deficits in adult male rodents after traumatic brain injury: a systematic review.Simvastatin treatment enhances NMDAR-mediated synaptic transmission by upregulating the surface distribution of the GluN2B subunit.Neuroprotection for traumatic brain injury: translational challenges and emerging therapeutic strategiesLovastatin modulates glycogen synthase kinase-3β pathway and inhibits mossy fiber sprouting after pilocarpine-induced status epilepticus.Molecular hydrogen reduces LPS-induced neuroinflammation and promotes recovery from sickness behaviour in miceSalidroside improves behavioral and histological outcomes and reduces apoptosis via PI3K/Akt signaling after experimental traumatic brain injury.Attenuation of astrogliosis and modulation of endothelial growth factor receptor in lipid rafts by simvastatin after traumatic brain injury.Traumatic brain injury and recovery mechanisms: peptide modulation of periventricular neurogenic regions by the choroid plexus-CSF nexus.A novel Akt3 mutation associated with enhanced kinase activity and seizure susceptibility in mice.Molecular mechanisms underlying the effects of statins in the central nervous system.Enriched environment prevents hypobaric hypoxia induced memory impairment and neurodegeneration: role of BDNF/PI3K/GSK3β pathway coupled with CREB activation.Chronic pravastatin but not atorvastatin treatment impairs cognitive function in two rodent models of learning and memoryForebrain neurogenesis after focal Ischemic and traumatic brain injury.Use of an adult rat retinal explant model for screening of potential retinal ganglion cell neuroprotective therapies.S-nitrosoglutathione reduces oxidative injury and promotes mechanisms of neurorepair following traumatic brain injury in rats.Reduced cholesterol is associated with the depressive-like behavior in rats through modulation of the brain 5-HT1A receptor.The influence of the brain-derived neurotropic factor Val66Met genotype and HMG-CoA reductase inhibitors on insulin resistance in the schizophrenia and bipolar populationsInvestigational agents for treatment of traumatic brain injuryIsoprenoids and related pharmacological interventions: potential application in Alzheimer's disease.HMG-CoA Reductase Inhibitors Bind to PPARα to Upregulate Neurotrophin Expression in the Brain and Improve Memory in Mice.Therapeutic benefit of treatment of stroke with simvastatin and human umbilical cord blood cells: neurogenesis, synaptic plasticity, and axon growthStimulation of functional recovery via the mechanisms of neurorepair by S-nitrosoglutathione and motor exercise in a rat model of transient cerebral ischemia and reperfusion.Neurotrauma: The Crosstalk between Neurotrophins and Inflammation in the Acutely Injured Brain.Simvastatin attenuates axonal injury after experimental traumatic brain injury and promotes neurite outgrowth of primary cortical neurons
P2860
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P2860
Simvastatin-mediated upregulation of VEGF and BDNF, activation of the PI3K/Akt pathway, and increase of neurogenesis are associated with therapeutic improvement after traumatic brain injury.
description
2008 nî lūn-bûn
@nan
2008年の論文
@ja
2008年学术文章
@wuu
2008年学术文章
@zh
2008年学术文章
@zh-cn
2008年学术文章
@zh-hans
2008年学术文章
@zh-my
2008年学术文章
@zh-sg
2008年學術文章
@yue
2008年學術文章
@zh-hant
name
Simvastatin-mediated upregulat ...... after traumatic brain injury.
@en
Simvastatin-mediated upregulat ...... after traumatic brain injury.
@nl
type
label
Simvastatin-mediated upregulat ...... after traumatic brain injury.
@en
Simvastatin-mediated upregulat ...... after traumatic brain injury.
@nl
prefLabel
Simvastatin-mediated upregulat ...... after traumatic brain injury.
@en
Simvastatin-mediated upregulat ...... after traumatic brain injury.
@nl
P2093
P356
P1476
Simvastatin-mediated upregulat ...... after traumatic brain injury.
@en
P2093
Asim Mahmood
Changsheng Qu
Hongtao Wu
P304
P356
10.1089/NEU.2007.0369
P577
2008-02-01T00:00:00Z