Alternative splicing disrupts a nuclear localization signal in spleen tyrosine kinase that is required for invasion suppression in breast cancer.
about
Genome-wide review of transcriptional complexity in mouse protein kinases and phosphatases.SYK expression in human breast cancerFunctional roles of Syk in macrophage-mediated inflammatory responsesNa+/H+ exchanger regulatory factor 1 inhibits platelet-derived growth factor signaling in breast cancer cellsThe Dok-3/Grb2 protein signal module attenuates Lyn kinase-dependent activation of Syk kinase in B cell antigen receptor microclustersSpliceNet: recovering splicing isoform-specific differential gene networks from RNA-Seq data of normal and diseased samples.p53 induces distinct epigenetic states at its direct target promoters.Predicting functional alternative splicing by measuring RNA selection pressure from multigenome alignmentsProtein arginine methyltransferase 6 regulates multiple aspects of gene expression.Regulation of Syk by phosphorylation on serine in the linker insertNucleocytoplasmic trafficking of the Syk protein tyrosine kinaseHMGB1 acts on microglia Mac1 to mediate chronic neuroinflammation that drives progressive neurodegeneration.Calling in SYK: SYK's dual role as a tumor promoter and tumor suppressor in cancer.Suppression of breast cancer cell growth by Na+/H+ exchanger regulatory factor 1 (NHERF1)Frequent epigenetic inactivation of spleen tyrosine kinase gene in human hepatocellular carcinoma.Hypermethylation of Syk gene in promoter region associated with oncogenesis and metastasis of gastric carcinomaMultiplexed quantitation of protein expression and phosphorylation based on functionalized soluble nanopolymers.CHK1 targets spleen tyrosine kinase (L) for proteolysis in hepatocellular carcinoma.The SYK tyrosine kinase: a crucial player in diverse biological functions.RNA sequencing of cancer reveals novel splicing alterations.Alternatively spliced tissue factor promotes breast cancer growth in a β1 integrin-dependent manner.Alternative splicing in the NF-kappaB signaling pathway.Alternative splicing of spleen tyrosine kinase differentially regulates colorectal cancer progression.Syk and pTyr'd: Signaling through the B cell antigen receptorRole of the protein tyrosine kinase Syk in regulating cell-cell adhesion and motility in breast cancer cells.Syk tyrosine kinase acts as a pancreatic adenocarcinoma tumor suppressor by regulating cellular growth and invasion.Quantitative immunofluorescence reveals the signature of active B-cell receptor signaling in diffuse large B-cell lymphoma.Splicing imbalances in basal-like breast cancer underpin perturbation of cell surface and oncogenic pathways and are associated with patients' survivalExpression of variant isoforms of the tyrosine kinase SYK determines the prognosis of hepatocellular carcinoma.Integrin clustering enables anandamide-induced Ca2+ signaling in endothelial cells via GPR55 by protection against CB1-receptor-triggered repressionSpleen tyrosine kinase functions as a tumor suppressor in melanoma cells by inducing senescence-like growth arrest.Transcription repressor activity of spleen tyrosine kinase mediates breast tumor suppressionSyk kinase as a treatment target for therapy in autoimmune diseases.High mRNA expression of splice variant SYK short correlates with hepatic disease progression in chemonaive lymph node negative colon cancer patients.Over expression of proteins that alter the intracellular signaling pathways in the cytoplasm of the liver cells forming Mallory-Denk bodies.SYK-targeted dendritic cell-mediated cytotoxic T lymphocytes enhance the effect of immunotherapy on retinoblastoma.SYK inhibition blocks proliferation and migration of glioma cells and modifies the tumor microenvironment.
P2860
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P2860
Alternative splicing disrupts a nuclear localization signal in spleen tyrosine kinase that is required for invasion suppression in breast cancer.
description
2003 nî lūn-bûn
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2003年の論文
@ja
2003年学术文章
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2003年学术文章
@zh
2003年学术文章
@zh-cn
2003年学术文章
@zh-hans
2003年学术文章
@zh-my
2003年学术文章
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2003年學術文章
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name
Alternative splicing disrupts ...... suppression in breast cancer.
@en
Alternative splicing disrupts ...... suppression in breast cancer.
@nl
type
label
Alternative splicing disrupts ...... suppression in breast cancer.
@en
Alternative splicing disrupts ...... suppression in breast cancer.
@nl
prefLabel
Alternative splicing disrupts ...... suppression in breast cancer.
@en
Alternative splicing disrupts ...... suppression in breast cancer.
@nl
P2093
P1433
P1476
Alternative splicing disrupts ...... suppression in breast cancer.
@en
P2093
Aysegul Sahin
Jia Le Dai
Lindsay Duke
Peter S Zhang
Ralph B Arlinghaus
Richard Mendez
W Fraser Symmans
P304
P407
P577
2003-08-01T00:00:00Z