Unique in vivo modifications of coagulation factor V produce a physically and functionally distinct platelet-derived cofactor: characterization of purified platelet-derived factor V/Va.
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Factor Va, bound to microparticles released during platelet storage, is resistant to inactivation by activated protein C.The factor V light chain mediates the binding and endocytosis of plasma-derived factor V by megakaryocytes.Comparative response of platelet fV and plasma fV to activated protein C and relevance to a model of acute traumatic coagulopathy.Recipient and donor thrombophilia and the risk of portal venous thrombosis and hepatic artery thrombosis in liver recipients.Polyphosphate modulates blood coagulation and fibrinolysis.Identification of the MMRN1 binding region within the C2 domain of human factor V.The molecular basis of factor V and VIII procofactor activationBlood coagulation factors V and VIII: Molecular Mechanisms of Procofactor Activation.Prothrombin activation on the activated platelet surface optimizes expression of procoagulant activity.Characterization of an autosomal dominant bleeding disorder caused by a thrombomodulin mutation.Exploration of the host haemostatic system by group A streptococcus: implications in searching for novel antimicrobial therapiesProperties of procoagulant platelets: defining and characterizing the subpopulation binding a functional prothrombinasePlatelets and platelet-derived factor Va confer hemostatic competence in complete factor V deficiency.Coagulation factor V mediates inhibition of tissue factor signaling by activated protein C in miceInherited defects of coagulation factor V: the hemorrhagic side.Genotype-phenotype correlation in combined deficiency of factor V and factor VIII.Reduced thrombin generation increases host susceptibility to group A streptococcal infectionProteolysis of plasma-derived factor V following its endocytosis by megakaryocytes forms the platelet-derived factor V/Va pool.Systemic blood coagulation activation in acute coronary syndromes.Platelets: developmental biology, physiology, and translatable platforms for preclinical investigation and drug development.Restoring the procofactor state of factor Va-like variants by complementation with B-domain peptidesPlatelet alpha-granules: basic biology and clinical correlates.Platelet secretion: From haemostasis to wound healing and beyond.Novel role for galectin-8 protein as mediator of coagulation factor V endocytosis by megakaryocytes.A unique function for LRP-1: a component of a two-receptor system mediating specific endocytosis of plasma-derived factor V by megakaryocytes.Platelet-Derived Factor V Is a Critical Mediator of Arterial Thrombosis.Endocytosis of plasma-derived factor V by megakaryocytes occurs via a clathrin-dependent, specific membrane binding event.Laparoscopic surgery in a woman with factor V deficiency: revisiting platelet factor V.Management of bleeding in severe factor V deficiency with a factor V inhibitor.TAILS N-Terminomics and proteomics reveal complex regulation of proteolytic cleavage by O-glycosylation.Effect of five therapeutic strategies on the coagulation defect induced by the thrombomodulin c.1611C>A mutation.Mechanisms Regulating Acquisition of Platelet-Derived Factor V/Va by Megakaryocytes.
P2860
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P2860
Unique in vivo modifications of coagulation factor V produce a physically and functionally distinct platelet-derived cofactor: characterization of purified platelet-derived factor V/Va.
description
2003 nî lūn-bûn
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2003年の論文
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2003年学术文章
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2003年学术文章
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2003年学术文章
@zh-cn
2003年学术文章
@zh-hans
2003年学术文章
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2003年學術文章
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name
Unique in vivo modifications o ...... platelet-derived factor V/Va.
@en
Unique in vivo modifications o ...... platelet-derived factor V/Va.
@nl
type
label
Unique in vivo modifications o ...... platelet-derived factor V/Va.
@en
Unique in vivo modifications o ...... platelet-derived factor V/Va.
@nl
prefLabel
Unique in vivo modifications o ...... platelet-derived factor V/Va.
@en
Unique in vivo modifications o ...... platelet-derived factor V/Va.
@nl
P2093
P2860
P356
P1476
Unique in vivo modifications o ...... platelet-derived factor V/Va.
@en
P2093
Jay R Silveira
Paula B Tracy
Weston R Gould
P2860
P304
P356
10.1074/JBC.M308600200
P407
P577
2003-10-31T00:00:00Z