Inhibition of poly(ADP-ribose) glycohydrolase (PARG) specifically kills BRCA2-deficient tumor cells.
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Function of BRCA1 in the DNA damage response is mediated by ADP-ribosylationStructures of the Human Poly (ADP-Ribose) Glycohydrolase Catalytic Domain Confirm Catalytic Mechanism and Explain Inhibition by ADP-HPD DerivativesHost cell poly(ADP-ribose) glycohydrolase is crucial for Trypanosoma cruzi infection cycleExome-Scale Discovery of Hotspot Mutation Regions in Human Cancer Using 3D Protein Structure.Molecular Insights into Poly(ADP-ribose) Recognition and Processing.The oligonucleotide/oligosaccharide-binding fold motif is a poly(ADP-ribose)-binding domain that mediates DNA damage responsePARG is dispensable for recovery from transient replicative stress but required to prevent detrimental accumulation of poly(ADP-ribose) upon prolonged replicative stress.A role of intracellular mono-ADP-ribosylation in cancer biology.A quantitative assay reveals ligand specificity of the DNA scaffold repair protein XRCC1 and efficient disassembly of complexes of XRCC1 and the poly(ADP-ribose) polymerase 1 by poly(ADP-ribose) glycohydrolase.Poly(ADP-ribosyl) glycohydrolase prevents the accumulation of unusual replication structures during unperturbed S phaseGallotannin imposes S phase arrest in breast cancer cells and suppresses the growth of triple-negative tumors in vivo.New paradigms in the repair of oxidative damage in human genome: mechanisms ensuring repair of mutagenic base lesions during replication and involvement of accessory proteins.Poly(ADP-Ribose) Glycohydrolase (PARG) Silencing Suppresses Benzo(a)pyrene Induced Cell Transformation.A Selective Small Molecule DNA2 Inhibitor for Sensitization of Human Cancer Cells to ChemotherapyIs there an epigenetic component underlying the resistance of triple-negative breast cancers to parp inhibitors?PARG deficiency is neither synthetic lethal with BRCA1 nor PTEN deficiencyThe FHA and BRCT domains recognize ADP-ribosylation during DNA damage response.The Sound of Silence: RNAi in Poly (ADP-Ribose) ResearchTargeting DNA Repair in Cancer: Beyond PARP Inhibitors.The recognition and removal of cellular poly(ADP-ribose) signals.The rise and fall of poly(ADP-ribose): An enzymatic perspective.Specific killing of DNA damage-response deficient cells with inhibitors of poly(ADP-ribose) glycohydrolase.Inhibition of poly(ADP-ribose) polymerase-1 or poly(ADP‑ribose) glycohydrolase individually, but not in combination, leads to improved chemotherapeutic efficacy in HeLa cells.Radiosensitization with an inhibitor of poly(ADP-ribose) glycohydrolase: A comparison with the PARP1/2/3 inhibitor olaparib.Specificity of reversible ADP-ribosylation and regulation of cellular processes.Purification of Recombinant Human PARP-3.Comprehensive analysis of telomerase inhibition by gallotannin.
P2860
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P2860
Inhibition of poly(ADP-ribose) glycohydrolase (PARG) specifically kills BRCA2-deficient tumor cells.
description
2012 nî lūn-bûn
@nan
2012年の論文
@ja
2012年学术文章
@wuu
2012年学术文章
@zh-cn
2012年学术文章
@zh-hans
2012年学术文章
@zh-my
2012年学术文章
@zh-sg
2012年學術文章
@yue
2012年學術文章
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2012年學術文章
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name
Inhibition of poly(ADP-ribose) ...... s BRCA2-deficient tumor cells.
@en
type
label
Inhibition of poly(ADP-ribose) ...... s BRCA2-deficient tumor cells.
@en
prefLabel
Inhibition of poly(ADP-ribose) ...... s BRCA2-deficient tumor cells.
@en
P2093
P2860
P356
P1433
P1476
Inhibition of poly(ADP-ribose) ...... s BRCA2-deficient tumor cells.
@en
P2093
Catherine Fathers
Helen E Bryant
Ross M Drayton
Svetlana Solovieva
P2860
P304
P356
10.4161/CC.11.5.19482
P577
2012-03-01T00:00:00Z