Smac/DIABLO selectively reduces the levels of c-IAP1 and c-IAP2 but not that of XIAP and livin in HeLa cells. - Wikidata - wikimedia - TriplyDB

Smac/DIABLO selectively reduces the levels of c-IAP1 and c-IAP2 but not that of XIAP and livin in HeLa cells.

Smac/DIABLO selectively reduces the levels of c-IAP1 and c-IAP2 but not that of XIAP and livin in HeLa cells.

http://www.wikidata.org/entity/Q44762625

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Research progress on Livin protein: an inhibitor of apoptosis The USP19 deubiquitinase regulates the stability of c-IAP1 and c-IAP2 Livin promotes Smac/DIABLO degradation by ubiquitin-proteasome pathway Small-molecule SMAC mimetics as new cancer therapeutics Interaction of heat-shock protein 90 beta isoform (HSP90 beta) with cellular inhibitor of apoptosis 1 (c-IAP1) is required for cell differentiation Ectopic expression of new alternative splice variant of Smac/DIABLO increases mammospheres formation Regulation of tumour necrosis factor signalling: live or let die Small molecules destabilize cIAP1 by activating auto-ubiquitylation Smac modulates chemosensitivity in head and neck cancer cells through the mitochondrial apoptotic pathway High Smac/DIABLO expression is associated with early local recurrence of cervical cancer An unconventional IAP-binding motif revealed by target-assisted iterative screening (TAIS) of the BIR3-cIAP1 domain.Auto-ubiquitination-induced degradation of MALT1-API2 prevents BCL10 destabilization in t(11;18)(q21;q21)-positive MALT lymphoma.Conjugation to a SMAC mimetic potentiates sigma-2 ligand induced tumor cell death in ovarian cancer Poly(I:C) induces intense expression of c-IAP2 and cooperates with an IAP inhibitor in induction of apoptosis in cancer cells.Monomerization of cytosolic mature smac attenuates interaction with IAPs and potentiation of caspase activation Tumor necrosis factor (TNF) signaling, but not TWEAK (TNF-like weak inducer of apoptosis)-triggered cIAP1 (cellular inhibitor of apoptosis protein 1) degradation, requires cIAP1 RING dimerization and E2 binding.Killer proteases and little strokes--how the things that do not kill you make you stronger.Determination of cell survival by RING-mediated regulation of inhibitor of apoptosis (IAP) protein abundance cIAP1 cooperatively inhibits procaspase-3 activation by the caspase-9 apoptosome The HIV-1 Vpu protein induces apoptosis in Drosophila via activation of JNK signaling Cellular inhibitor of apoptosis protein-1 (cIAP1) plays a critical role in β-cell survival under endoplasmic reticulum stress: promoting ubiquitination and degradation of C/EBP homologous protein (CHOP)Cyclopeptide Smac mimetics as antagonists of IAP proteins.Novel link between E2F1 and Smac/DIABLO: proapoptotic Smac/DIABLO is transcriptionally upregulated by E2F1.Cadmium down-regulates expression of XIAP at the post-transcriptional level in prostate cancer cells through an NF-kappaB-independent, proteasome-mediated mechanism.HAX1 regulates E3 ubiquitin ligase activity of cIAPs by promoting their dimerization Smac mimetics increase cancer cell response to chemotherapeutics in a TNF-α-dependent manner Splice variants of mIAP1 have an enhanced ability to inhibit apoptosis TRIM32 protein sensitizes cells to tumor necrosis factor (TNFα)-induced apoptosis via its RING domain-dependent E3 ligase activity against X-linked inhibitor of apoptosis (XIAP).Immune unresponsiveness to secondary heterologous bacterial infection after sepsis induction is TRAIL dependent The IAP-antagonist ARTS initiates caspase activation upstream of cytochrome C and SMAC/Diablo.Inhibitor of apoptosis proteins as intracellular signaling intermediates.Molecular characterization of protein kinase C delta (PKCδ)-Smac interactions.IAP antagonists Birinapant and AT-406 efficiently synergise with either TRAIL, BRAF, or BCL-2 inhibitors to sensitise BRAFV600E colorectal tumour cells to apoptosis.A potent and orally active antagonist (SM-406/AT-406) of multiple inhibitor of apoptosis proteins (IAPs) in clinical development for cancer treatment.SMAC mimetic Debio 1143 synergizes with taxanes, topoisomerase inhibitors and bromodomain inhibitors to impede growth of lung adenocarcinoma cells.The RING domain of cIAP1 mediates the degradation of RING-bearing inhibitor of apoptosis proteins by distinct pathways.Multifaceted targeting in cancer: the recent cell death players meet the usual oncogene suspects.Killing of macrophages by anthrax lethal toxin: involvement of the N-end rule pathway.Role of Smac/DIABLO in cancer progression.Ubiquitin ligases in cancer: ushers for degradation.

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P2860

Smac/DIABLO selectively reduces the levels of c-IAP1 and c-IAP2 but not that of XIAP and livin in HeLa cells.

http://www.wikidata.org/entity/Q44762625

description

2004 nî lūn-bûn

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2004年の論文

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2004年学术文章

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2004年学术文章

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2004年学术文章

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2004年学术文章

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2004年学术文章

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2004年学术文章

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2004年學術文章

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2004年學術文章

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name

Smac/DIABLO selectively reduce ...... XIAP and livin in HeLa cells.

@en

Smac/DIABLO selectively reduce ...... XIAP and livin in HeLa cells.

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type

label

Smac/DIABLO selectively reduce ...... XIAP and livin in HeLa cells.

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Smac/DIABLO selectively reduce ...... XIAP and livin in HeLa cells.

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prefLabel

Smac/DIABLO selectively reduce ...... XIAP and livin in HeLa cells.

@en

Smac/DIABLO selectively reduce ...... XIAP and livin in HeLa cells.

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P1476

Smac/DIABLO selectively reduce ...... XIAP and livin in HeLa cells.

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P2093

Chunying Du

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Qi-Heng Yang

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P2860

Molecular determinants of the caspase-promoting activity of Smac/DIABLO and its role in the death receptor pathway

ML-IAP, a novel inhibitor of apoptosis that is preferentially expressed in human melanomas

A serine protease, HtrA2, is released from the mitochondria and interacts with XIAP, inducing cell death

The serine protease Omi/HtrA2 regulates apoptosis by binding XIAP through a reaper-like motif

HtrA2 promotes cell death through its serine protease activity and its ability to antagonize inhibitor of apoptosis proteins

TNF-RII and c-IAP1 mediate ubiquitination and degradation of TRAF2

Induction of TNF receptor I-mediated apoptosis via two sequential signaling complexes

Identification of a family of closely related human ubiquitin conjugating enzymes

Cloning of human ubiquitin-conjugating enzymes UbcH6 and UbcH7 (E2-F1) and characterization of their interaction with E6-AP and RSP5

The tumor necrosis factor receptor 2 signal transducers TRAF2 and c-IAP1 are components of the tumor necrosis factor receptor 1 signaling complex

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16963-16970

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scholarly article

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10.1074/JBC.M401253200

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17

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279

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2004-02-11T00:00:00Z

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14960576

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