Characterization, crystallization and preliminary X-ray analysis of bifunctional dihydrofolate reductase-thymidylate synthase from Plasmodium falciparum.
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Exploiting Structural Analysis, in Silico Screening, and Serendipity To Identify Novel Inhibitors of Drug-Resistant Falciparum MalariaPreclinical Evaluation of the Antifolate QN254, 5-Chloro- N'6'-(2,5-Dimethoxy-Benzyl)-Quinazoline-2,4,6-Triamine, as an Antimalarial Drug CandidateMalarial dihydrofolate reductase as a paradigm for drug development against a resistance-compromised targetCombined Spatial Limitation around Residues 16 and 108 of Plasmodium falciparum Dihydrofolate Reductase Explains Resistance to CycloguanilInducible knockdown of Plasmodium gene expression using the glmS ribozymeTargeting purine and pyrimidine metabolism in human apicomplexan parasitesThe structure of Plasmodium falciparum serine hydroxymethyltransferase reveals a novel redox switch that regulates its activities.Crystallization and preliminary crystallographic analysis of β-mannanase from Bacillus licheniformisStructures of Plasmodium vivax serine hydroxymethyltransferase: implications for ligand-binding specificity and functional control.Evaluation of the activities of pyrimethamine analogs against Plasmodium vivax and Plasmodium falciparum dihydrofolate reductase-thymidylate synthase using in vitro enzyme inhibition and bacterial complementation assays.Crystallization and preliminary X-ray analysis of the reductase component of p-hydroxyphenylacetate 3-hydroxylase from Acinetobacter baumannii.Comparative folate metabolism in humans and malaria parasites (part I): pointers for malaria treatment from cancer chemotherapy.Cloning and heterologous expression of Plasmodium ovale dihydrofolate reductase-thymidylate synthase geneFolate metabolism as a source of molecular targets for antimalarials.Probing the role of parasite-specific, distant structural regions on communication and catalysis in the bifunctional thymidylate synthase-dihydrofolate reductase from Plasmodium falciparumCrystallization and preliminary crystallographic studies of dihydrofolate reductase-thymidylate synthase from Trypanosoma cruzi, the Chagas disease pathogen.Improved X-ray diffraction from Bacillus megaterium penicillin G acylase crystals through long cryosoaking dehydration.Crystallization and preliminary X-ray crystallographic analysis of 2-methyl-3-hydroxypyridine-5-carboxylic acid (MHPC) oxygenase from Pseudomonas sp. MA-1.Formation of catalytically active cross-species heterodimers of thymidylate synthase from Plasmodium falciparum and Plasmodium vivax.Molecular dynamics of interactions between rigid and flexible antifolates and dihydrofolate reductase from pyrimethamine-sensitive and pyrimethamine-resistant Plasmodium falciparum.
P2860
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P2860
Characterization, crystallization and preliminary X-ray analysis of bifunctional dihydrofolate reductase-thymidylate synthase from Plasmodium falciparum.
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2004 nî lūn-bûn
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2004年の論文
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2004年学术文章
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name
Characterization, crystallizat ...... se from Plasmodium falciparum.
@en
Characterization, crystallizat ...... se from Plasmodium falciparum.
@nl
type
label
Characterization, crystallizat ...... se from Plasmodium falciparum.
@en
Characterization, crystallizat ...... se from Plasmodium falciparum.
@nl
prefLabel
Characterization, crystallizat ...... se from Plasmodium falciparum.
@en
Characterization, crystallizat ...... se from Plasmodium falciparum.
@nl
P2093
P50
P1476
Characterization, crystallizat ...... se from Plasmodium falciparum.
@en
P2093
Jarunee Vanichtanankul
Jirundon Yuvaniyama
Penchit Chitnumsub
P304
P356
10.1107/S0907444904001544
P577
2004-03-23T00:00:00Z