Dissecting the cell-killing mechanism of the topoisomerase II-targeting drug ICRF-193.
about
Characterisation of cytotoxicity and DNA damage induced by the topoisomerase II-directed bisdioxopiperazine anti-cancer agent ICRF-187 (dexrazoxane) in yeast and mammalian cellsDifferential regulation of NF-kappaB activation and function by topoisomerase II inhibitorsMitotic chromosomes are constrained by topoisomerase II-sensitive DNA entanglements.Mouse spermatozoa contain a nuclease that is activated by pretreatment with EGTA and subsequent calcium incubation.Nuclear dynamics of topoisomerase IIβ reflects its catalytic activity that is regulated by binding of RNA to the C-terminal domainStudying vertebrate topoisomerase 2 function using a conditional knockdown system in DT40 cells.A non-canonical function of topoisomerase II in disentangling dysfunctional telomeresTopBP1 is required at mitosis to reduce transmission of DNA damage to G1 daughter cells.Hindering the strand passage reaction of human topoisomerase IIalpha without disturbing DNA cleavage, ATP hydrolysis, or the operation of the N-terminal clamp.
P2860
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P2860
Dissecting the cell-killing mechanism of the topoisomerase II-targeting drug ICRF-193.
description
2004 nî lūn-bûn
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2004年の論文
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2004年学术文章
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name
Dissecting the cell-killing mechanism of the topoisomerase II-targeting drug ICRF-193.
@en
Dissecting the cell-killing mechanism of the topoisomerase II-targeting drug ICRF-193.
@nl
type
label
Dissecting the cell-killing mechanism of the topoisomerase II-targeting drug ICRF-193.
@en
Dissecting the cell-killing mechanism of the topoisomerase II-targeting drug ICRF-193.
@nl
prefLabel
Dissecting the cell-killing mechanism of the topoisomerase II-targeting drug ICRF-193.
@en
Dissecting the cell-killing mechanism of the topoisomerase II-targeting drug ICRF-193.
@nl
P2860
P356
P1476
Dissecting the cell-killing mechanism of the topoisomerase II-targeting drug ICRF-193.
@en
P2093
Anni H Andersen
Birgitta R Knudsen
P2860
P304
28100-28105
P356
10.1074/JBC.M402119200
P407
P577
2004-04-28T00:00:00Z