Analysis of functional domain organization in DNA topoisomerase II from humans and Saccharomyces cerevisiae
about
Using a biochemical approach to identify the primary dimerization regions in human DNA topoisomerase IIalphaNuclear interactions of topoisomerase II alpha and beta with phospholipid scramblase 1Cellular distribution of mammalian DNA topoisomerase II is determined by its catalytically dispensable C-terminal domainCentromere-associated topoisomerase activity in bloodstream form Trypanosoma bruceiA novel chromatin tether domain controls topoisomerase IIα dynamics and mitotic chromosome formation.Granzyme M targets topoisomerase II alpha to trigger cell cycle arrest and caspase-dependent apoptosis.Phosphorylation of serine 1106 in the catalytic domain of topoisomerase II alpha regulates enzymatic activity and drug sensitivity.The impact of the human DNA topoisomerase II C-terminal domain on activity.The use of divalent metal ions by type II topoisomerases.Clonality characterization of natural epitope-specific antibodies against the tumor-related antigen topoisomerase IIa by peptide chip and proteome analysis: a pilot study with colorectal carcinoma patient samples.Dynamics of human DNA topoisomerases IIalpha and IIbeta in living cellsCloning, functional analysis and post-transcriptional regulation of a type II DNA topoisomerase from Leishmania infantum. A new potential target for anti-parasite drugs.HMGB1 interacts with human topoisomerase IIalpha and stimulates its catalytic activity.Modulation of drug sensitivity in yeast cells by the ATP-binding domain of human DNA topoisomerase IIalphaChiral discrimination and writhe-dependent relaxation mechanism of human topoisomerase IIα.Bimodal recognition of DNA geometry by human topoisomerase II alpha: preferential relaxation of positively supercoiled DNA requires elements in the C-terminal domainImpact of the C-terminal domain of topoisomerase IIalpha on the DNA cleavage activity of the human enzyme.A human topoisomerase II alpha heterodimer with only one ATP binding site can go through successive catalytic cycles.Functional dissection of the C-terminal domain of type II DNA topoisomerase from the kinetoplastid hemoflagellate Leishmania donovani.C-terminal regions of topoisomerase IIalpha and IIbeta determine isoform-specific functioning of the enzymes in vivo.cin-4, a gene with homology to topoisomerase II, is required for centromere resolution by cohesin removal from sister kinetochores during mitosis.ATPase domain of eukaryotic DNA topoisomerase II. Inhibition of ATPase activity by the anti-cancer drug bisdioxopiperazine and ATP/ADP-induced dimerization.The transducer domain is important for clamp operation in human DNA topoisomerase IIalpha.Hindering the strand passage reaction of human topoisomerase IIalpha without disturbing DNA cleavage, ATP hydrolysis, or the operation of the N-terminal clamp.Dissecting the cell-killing mechanism of the topoisomerase II-targeting drug ICRF-193.
P2860
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P2860
Analysis of functional domain organization in DNA topoisomerase II from humans and Saccharomyces cerevisiae
description
1996 nî lūn-bûn
@nan
1996年の論文
@ja
1996年学术文章
@wuu
1996年学术文章
@zh-cn
1996年学术文章
@zh-hans
1996年学术文章
@zh-my
1996年学术文章
@zh-sg
1996年學術文章
@yue
1996年學術文章
@zh
1996年學術文章
@zh-hant
name
Analysis of functional domain ...... s and Saccharomyces cerevisiae
@en
type
label
Analysis of functional domain ...... s and Saccharomyces cerevisiae
@en
prefLabel
Analysis of functional domain ...... s and Saccharomyces cerevisiae
@en
P2093
P2860
P356
P1476
Analysis of functional domain ...... s and Saccharomyces cerevisiae
@en
P2093
Andersen AH
Andersen TB
Biersack H
Jakobsen BK
Kjeldsen E
Westergaard O
P2860
P304
P356
10.1128/MCB.16.7.3866
P407
P577
1996-07-01T00:00:00Z