Purine salvage pathways in the apicomplexan parasite Toxoplasma gondii. - Wikidata - wikimedia - TriplyDB

Purine salvage pathways in the apicomplexan parasite Toxoplasma gondii.

Purine salvage pathways in the apicomplexan parasite Toxoplasma gondii.

http://www.wikidata.org/entity/Q44894421

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Genomic-scale prioritization of drug targets: the TDR Targets database Host cell manipulation by the human pathogen Toxoplasma gondii Transition-state inhibitors of purine salvage and other prospective enzyme targets in malaria De novo GTP Biosynthesis Is Critical for Virulence of the Fungal Pathogen Cryptococcus neoformans Structural Determinants of the 5′-Methylthioinosine Specificity of Plasmodium Purine Nucleoside Phosphorylase Inhibition and Structure of Toxoplasma gondii Purine Nucleoside Phosphorylase Malaria parasite type 4 equilibrative nucleoside transporters (ENT4) are purine transporters with distinct substrate specificity A screening pipeline for antiparasitic agents targeting cryptosporidium inosine monophosphate dehydrogenase Targeting purine and pyrimidine metabolism in human apicomplexan parasites Nephromyces, a beneficial apicomplexan symbiont in marine animals.Differential localization of alternatively spliced hypoxanthine-xanthine-guanine phosphoribosyltransferase isoforms in Toxoplasma gondii.Communication between Toxoplasma gondii and its host: impact on parasite growth, development, immune evasion, and virulence.Metabolic reconstruction identifies strain-specific regulation of virulence in Toxoplasma gondii.IMP dehydrogenase from the protozoan parasite Toxoplasma gondii.A link between impaired purine nucleotide synthesis and apoptosis in Drosophila melanogaster.Asexual expansion of Toxoplasma gondii merozoites is distinct from tachyzoites and entails expression of non-overlapping gene families to attach, invade, and replicate within feline enterocytes.Targeted disruption of Toxoplasma gondii serine protease inhibitor 1 increases bradyzoite cyst formation in vitro and parasite tissue burden in mice.Conditional mutagenesis of a novel choline kinase demonstrates plasticity of phosphatidylcholine biogenesis and gene expression in Toxoplasma gondii.Synthesis, biological evaluation and molecular modeling studies of N6-benzyladenosine analogues as potential anti-toxoplasma agents.Purine and pyrimidine transport in pathogenic protozoa: from biology to therapy.Genome content analysis yields new insights into the relationship between the human malaria parasite Plasmodium falciparum and its anopheline vectors CD73-generated adenosine facilitates Toxoplasma gondii differentiation to long-lived tissue cysts in the central nervous system.Purine salvage pathways in the intraerythrocytic malaria parasite Plasmodium falciparum.Genetic evidence for the essential role of PfNT1 in the transport and utilization of xanthine, guanine, guanosine and adenine by Plasmodium falciparum Glycobiology of the Leishmania parasite and emerging targets for antileishmanial drug discovery.A plant/fungal-type phosphoenolpyruvate carboxykinase located in the parasite mitochondrion ensures glucose-independent survival of Toxoplasma gondii.Withdrawal of skeletal muscle cells from cell cycle progression triggers differentiation of Toxoplasma gondii towards the bradyzoite stage.Metabolic signatures of Besnoitia besnoiti-infected endothelial host cells and blockage of key metabolic pathways indicate high glycolytic and glutaminolytic needs of the parasite.New host nuclear functions are not required for the modifications of the parasitophorous vacuole of Toxoplasma.[How does the apicomplexan parasite Theileria control host cell identity?].Plasmodium falciparum purine nucleoside phosphorylase is critical for viability of malaria parasites.Kinetic mechanism of Toxoplasma gondii adenosine kinase and the highly efficient utilization of adenosine.Toxoplasma gondii purine nucleoside phosphorylase biochemical characterization, inhibitor profiles, and comparison with the Plasmodium falciparum ortholog.Purine salvage in the apicomplexan Sarcocystis neurona, and generation of hypoxanthine-xanthine-guanine phosphoribosyltransferase-deficient clones for positive-negative selection of transgenic parasites.Hepatic Metabolomics Investigation in Acute and Chronic Murine Toxoplasmosis.Functions in the Fat Body To Promote Sleep

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P2860

Purine salvage pathways in the apicomplexan parasite Toxoplasma gondii.

http://www.wikidata.org/entity/Q44894421

description

2004 nî lūn-bûn

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2004年学术文章

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Purine salvage pathways in the apicomplexan parasite Toxoplasma gondii.

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Purine salvage pathways in the apicomplexan parasite Toxoplasma gondii.

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Purine salvage pathways in the apicomplexan parasite Toxoplasma gondii.

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Purine salvage pathways in the apicomplexan parasite Toxoplasma gondii.

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Purine salvage pathways in the apicomplexan parasite Toxoplasma gondii.

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Purine salvage pathways in the apicomplexan parasite Toxoplasma gondii.

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Purine salvage pathways in the apicomplexan parasite Toxoplasma gondii.

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P2093

Buddy Ullman

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Elmer R Pfefferkorn

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Kshitiz Chaudhary

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Leah M Fohl

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Robert G K Donald

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William J Sullivan

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P2860

The crystal structure of human hypoxanthine-guanine phosphoribosyltransferase with bound GMP

The 2.0 A structure of malarial purine phosphoribosyltransferase in complex with a transition-state analogue inhibitor

Crystal structures of Toxoplasma gondii HGXPRTase reveal the catalytic role of a long flexible loop

Structure of human adenosine kinase at 1.5 A resolution

Cloning and expression in Escherichia coli of a hypoxanthine-guanine phosphoribosyltransferase-encoding cDNA from Plasmodium falciparum

Isolation and functional characterization of the PfNT1 nucleoside transporter gene from Plasmodium falciparum

PlasmoDB: the Plasmodium genome resource. An integrated database providing tools for accessing, analyzing and mapping expression and sequence data (both finished and unfinished).

Genetic complementation in apicomplexan parasites

Insertional tagging of at least two loci associated with resistance to adenine arabinoside in Toxoplasma gondii, and cloning of the adenosine kinase locus.

The adenosine transporter of Toxoplasma gondii. Identification by insertional mutagenesis, cloning, and recombinant expression.

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31221-31227

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30

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279

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Toxoplasma gondii