Genomic-scale prioritization of drug targets: the TDR Targets database
about
Identification of attractive drug targets in neglected-disease pathogens using an in silico approachDrug target prediction and prioritization: using orthology to predict essentiality in parasite genomesA review of the global burden, novel diagnostics, therapeutics, and vaccine targets for cryptosporidium.Structure and dynamics of molecular networks: a novel paradigm of drug discovery: a comprehensive reviewCrystal structures of Mycobacterium tuberculosis HspAT and ArAT reveal structural basis of their distinct substrate specificities.RNA interference in Schistosoma mansoni schistosomula: selectivity, sensitivity and operation for larger-scale screeningTargeting protein-protein interactions for parasite controlBiochemical and structural characterization of CYP124: A methyl-branched lipid -hydroxylase from Mycobacterium tuberculosisThe Crystal Structure and Activity of a Putative Trypanosomal Nucleoside Phosphorylase Reveal It to be a Homodimeric Uridine PhosphorylaseAssay strategies for the discovery and validation of therapeutics targeting Brugia pahangi Hsp90A kernel for open source drug discovery in tropical diseasesAdvancing drug innovation for neglected diseases-criteria for lead progressionThe Mycobacterium tuberculosis drugome and its polypharmacological implicationsIntegrated dataset of screening hits against multiple neglected disease pathogensHelmCoP: an online resource for helminth functional genomics and drug and vaccine targets prioritizationComparative genomics analysis of Mycobacterium ulcerans for the identification of putative essential genes and therapeutic candidatesExoproteome and secretome derived broad spectrum novel drug and vaccine candidates in Vibrio cholerae targeted by Piper betel derived compoundsKinetic mechanism determination and analysis of metal requirement of dehydroquinate synthase from Mycobacterium tuberculosis H37Rv: an essential step in the function-based rational design of anti-TB drugsThe open access malaria box: a drug discovery catalyst for neglected diseasesPrediction of the P. falciparum target space relevant to malaria drug discoveryIn silico repositioning-chemogenomics strategy identifies new drugs with potential activity against multiple life stages of Schistosoma mansoniApplication of RNAi to Genomic Drug Target Validation in SchistosomesTo Hit or Not to Hit, That Is the Question - Genome-wide Structure-Based Druggability Predictions for Pseudomonas aeruginosa ProteinsA Novel Trypanosoma cruzi Protein Associated to the Flagellar Pocket of Replicative Stages and Involved in Parasite GrowthDistinctive Behaviors of Druggable Proteins in Cellular NetworksA Multilayer Network Approach for Guiding Drug Repositioning in Neglected DiseasesThe drug target genes show higher evolutionary conservation than non-target genesDEG 10, an update of the database of essential genes that includes both protein-coding genes and noncoding genomic elementsStructural Characterization and Ligand/Inhibitor Identification Provide Functional Insights into the Mycobacterium tuberculosis Cytochrome P450 CYP126A1TiPs: a database of therapeutic targets in pathogens and associated toolsModBase, a database of annotated comparative protein structure models and associated resources.TuberQ: a Mycobacterium tuberculosis protein druggability databaseNatural products as starting points for future anti-malarial therapies: going back to our roots?Rapid analysis of pharmacology for infectious diseasesDrug discovery and the use of computational approaches for infectious diseases.Strategic protein target analysis for developing drugs to stop dental caries.Metabolic network analysis predicts efficacy of FDA-approved drugs targeting the causative agent of a neglected tropical diseaseLeishCyc: a biochemical pathways database for Leishmania major.Computational prediction of essential genes in an unculturable endosymbiotic bacterium, Wolbachia of Brugia malayiChEMBL. An interview with John Overington, team leader, chemogenomics at the European Bioinformatics Institute Outstation of the European Molecular Biology Laboratory (EMBL-EBI). Interview by Wendy A. Warr
P2860
Q21144522-6CDA184C-E231-4AA5-A4A8-34E5BE5C57BFQ21267230-614C0808-AEBC-4796-9209-62F4D6990C08Q26851900-C69F7DC0-21FA-4D33-B00F-6DFB174D9E03Q27008867-DF064871-E85E-44C4-B06C-EEA3B97C01E4Q27302759-FA46E8A8-28A4-49F9-906F-2215FB8F8F07Q27306710-7D34A689-4B9C-4934-9B03-B1FB513873BDQ27348831-E6B0D041-510C-4882-9783-9021C0FAAD29Q27658311-FBFB1DF6-A378-4068-9DE1-663B9C6838A1Q27658939-9C1DEAC5-ECB6-4F84-9FDA-C53CB507F275Q28474428-460E257B-C8D1-4497-ABCC-298113D044AAQ28475314-BC1E6FBD-2885-4CD9-AF97-4A027D9E3849Q28475996-F6B17199-FBC9-4D8D-95E4-592E342C70F1Q28476004-15EF24AE-9F05-4973-B3A9-31BFE5C65665Q28478485-D04D4702-4C21-4C77-9068-9C1FF6904759Q28478955-8839017E-19C6-4212-882A-FBE23AB2FDA9Q28482216-C993E616-D58E-45F2-81B0-C30FEA46535CQ28485375-2FCECB86-345F-4256-9BF8-5CA0332FE6DEQ28486831-F1F060E5-445B-4973-AA14-8D7789F5A5D7Q28533977-319A1B9B-5112-46A7-BD9D-CF764488E82CQ28534474-408E76DC-EA74-4638-B922-A8F7D7763415Q28542999-8DC3C04F-7B47-4AE5-A023-C6878F447FE8Q28547348-E3A8C7DE-0152-4CBE-B747-8C79B2C9C5BEQ28547877-DF789E81-176F-4475-A086-1D2EA9C5B189Q28548459-BFCC5767-2BEE-47ED-9201-E2911E691B23Q28551715-FE5E8784-7762-4579-AB6E-445C9E9D45F8Q28552140-70278E6C-8DB3-4D29-8EEC-407D0F35AE07Q28600967-D060F2DC-9885-4D90-8BCC-D23A3D6664CFQ28660716-0D053B6B-8379-4437-9F8E-A4702EB43ADAQ28818082-F5257B16-F073-4CD1-B705-4E438DC0506FQ29048180-CF9A6ECD-DC73-412D-9009-4F255E2A18AEQ30355976-95016A7B-98E4-4E9E-91B3-7F75E8FBC1DDQ30362399-117C8DD6-B10F-4213-B832-D6042C2AD975Q30396384-2DF07C78-E6B8-4C0F-9A81-9E6EDBD02A34Q30400724-3E45CDF9-B199-4E3E-91D3-0FC72594985DQ30404272-7FA69906-D049-49AE-B2AA-BC2CBDB57DB0Q30420409-99B7D8C2-49C2-4873-8790-58CC631A8B63Q30426102-30C91B17-EFDD-4D7F-A065-C67E75953121Q30488352-8495BAEE-CBE8-4A39-908B-5277E63B45BDQ30923985-18314511-EC69-4BD5-8F08-3A971A47C3DBQ33384498-efe814bf-45ff-9b67-5ee5-20a85c783def
P2860
Genomic-scale prioritization of drug targets: the TDR Targets database
description
2008 nî lūn-bûn
@nan
2008 թուականի Նոյեմբերին հրատարակուած գիտական յօդուած
@hyw
2008 թվականի նոյեմբերին հրատարակված գիտական հոդված
@hy
2008年の論文
@ja
2008年論文
@yue
2008年論文
@zh-hant
2008年論文
@zh-hk
2008年論文
@zh-mo
2008年論文
@zh-tw
2008年论文
@wuu
name
Genomic-scale prioritization of drug targets: the TDR Targets database
@ast
Genomic-scale prioritization of drug targets: the TDR Targets database
@en
Genomic-scale prioritization of drug targets: the TDR Targets database
@nl
type
label
Genomic-scale prioritization of drug targets: the TDR Targets database
@ast
Genomic-scale prioritization of drug targets: the TDR Targets database
@en
Genomic-scale prioritization of drug targets: the TDR Targets database
@nl
prefLabel
Genomic-scale prioritization of drug targets: the TDR Targets database
@ast
Genomic-scale prioritization of drug targets: the TDR Targets database
@en
Genomic-scale prioritization of drug targets: the TDR Targets database
@nl
P2093
P2860
P50
P3181
P356
P1476
Genomic-scale prioritization of drug targets: the TDR Targets database
@en
P2093
A W Edith Chan
Aaron Riechers
Christophe L M J Verlinde
Dhanasekaran Shanmugam
Frederick S Buckner
Gaia V Paolini
Gregg McAllister
Ian M Carruthers
Maria A Doyle
P2860
P2888
P3181
P356
10.1038/NRD2684
P407
P50
P577
2008-11-01T00:00:00Z
P5875
P6179
1023310534