Competition for talin results in trans-dominant inhibition of integrin activation.
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Kindlin-1 and -2 directly bind the C-terminal region of beta integrin cytoplasmic tails and exert integrin-specific activation effectsThe Structure of the N-Terminus of Kindlin-1: A Domain Important for αIIbβ3 Integrin ActivationStructure of a double ubiquitin-like domain in the talin head: a role in integrin activationThe integrin antagonist cilengitide activates alphaVbeta3, disrupts VE-cadherin localization at cell junctions and enhances permeability in endothelial cellsβ1 integrins regulate fibroblast chemotaxis through control of N-WASP stability.Identification of the Kelch family protein Nd1-L as a novel molecular interactor of KRIT1ADAP is required for normal alphaIIbbeta3 activation by VWF/GP Ib-IX-V and other agonists.PIPKI gamma 90 negatively regulates LFA-1-mediated adhesion and activation in antigen-induced CD4+ T cells.Defective osteoblast function in ICAP-1-deficient miceRecreation of the terminal events in physiological integrin activation.Alpha v beta3 integrin spatially regulates VASP and RIAM to control adhesion dynamics and migration.Talins and kindlins: partners in integrin-mediated adhesion.The final steps of integrin activation: the end gameLoss of beta1-integrin enhances TGF-beta1-induced collagen expression in epithelial cells via increased alphavbeta3-integrin and Rac1 activity.A role for talin in presynaptic function.Mammary gland ECM remodeling, stiffness, and mechanosignaling in normal development and tumor progressionAbsence of Dap12 and the αvβ3 integrin causes severe osteopetrosis.Integrin-specific control of focal adhesion kinase and RhoA regulates membrane protrusion and invasion.Integrin-linked kinase regulates integrin signaling in human trabecular meshwork cells.The integrin-linked kinase-PINCH-parvin complex supports integrin αIIbβ3 activation.Control of C. elegans hermaphrodite gonad size and shape by vab-3/Pax6-mediated regulation of integrin receptors.Type I gamma phosphatidylinositol phosphate kinase is required for EGF-stimulated directional cell migrationMatrix-dependent perturbation of TGFβ signaling and diseaseRegulation of the interaction between PIPKI gamma and talin by proline-directed protein kinases.Reelin controls neuronal positioning by promoting cell-matrix adhesion via inside-out activation of integrin α5β1Ubiquitylation of phosphatidylinositol 4-phosphate 5-kinase type I γ by HECTD1 regulates focal adhesion dynamics and cell migration.Interactions of platelet integrin alphaIIb and beta3 transmembrane domains in mammalian cell membranes and their role in integrin activationGenetic transfer of fusion proteins effectively inhibits VCAM-1-mediated cell adhesion and transmigration via inhibition of cytoskeletal anchorage.αV-class integrins exert dual roles on α5β1 integrins to strengthen adhesion to fibronectin.Transdominant regulation of integrin function: mechanisms of crosstalk.Signaling pathways and the cerebral cavernous malformations proteins: lessons from structural biology.Mechanisms of talin-dependent integrin signaling and crosstalkInsights into adhesion biology using single-molecule localization microscopy.α3β1 integrins regulate CD151 complex assembly and membrane dynamics in carcinoma cells within 3D environments.Integrin cross-talk in endothelial cells is regulated by protein kinase A and protein phosphatase 1.Mixed extracellular matrix ligands synergistically modulate integrin adhesion and signaling.Accessibility to the fibronectin synergy site in a 3D matrix regulates engagement of alpha5beta1 versus alphavbeta3 integrin receptors.Adrenomedullin increases fibroblast-like synoviocyte adhesion to extracellular matrix proteins by upregulating integrin activation.Caspase-8 association with the focal adhesion complex promotes tumor cell migration and metastasisExpression of integrins on human choroidal neovascular membranes.
P2860
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P2860
Competition for talin results in trans-dominant inhibition of integrin activation.
description
2004 nî lūn-bûn
@nan
2004年の論文
@ja
2004年学术文章
@wuu
2004年学术文章
@zh-cn
2004年学术文章
@zh-hans
2004年学术文章
@zh-my
2004年学术文章
@zh-sg
2004年學術文章
@yue
2004年學術文章
@zh
2004年學術文章
@zh-hant
name
Competition for talin results in trans-dominant inhibition of integrin activation.
@en
Competition for talin results in trans-dominant inhibition of integrin activation.
@nl
type
label
Competition for talin results in trans-dominant inhibition of integrin activation.
@en
Competition for talin results in trans-dominant inhibition of integrin activation.
@nl
prefLabel
Competition for talin results in trans-dominant inhibition of integrin activation.
@en
Competition for talin results in trans-dominant inhibition of integrin activation.
@nl
P2093
P2860
P356
P1476
Competition for talin results in trans-dominant inhibition of integrin activation.
@en
P2093
David A Calderwood
Gilbert Di Paolo
Mark H Ginsberg
P2860
P304
28889-28895
P356
10.1074/JBC.M402161200
P407
P577
2004-05-13T00:00:00Z