Human liver cholesteryl ester hydrolase: cloning, molecular characterization, and role in cellular cholesterol homeostasis.
about
Genomics and proteomics of vertebrate cholesterol ester lipase (LIPA) and cholesterol 25-hydroxylase (CH25H)Macrophage cholesteryl ester mobilization and atherosclerosisCarboxylesterases: Dual roles in lipid and pesticide metabolism.Age-related inducibility of carboxylesterases by the antiepileptic agent phenobarbital and implications in drug metabolism and lipid accumulation.Activity-based protein profiling identifies a host enzyme, carboxylesterase 1, which is differentially active during hepatitis C virus replication.C57Bl/6 N mice on a western diet display reduced intestinal and hepatic cholesterol levels despite a plasma hypercholesterolemiaReverse cholesterol transport is elevated in carboxyl ester lipase-knockout miceHypolipidemic agent Z-guggulsterone: metabolism interplays with induction of carboxylesterase and bile salt export pumpQuantitative proteomics analysis reveals glutamine deprivation activates fatty acid β-oxidation pathway in HepG2 cells.Macrophage-specific transgenic expression of cholesteryl ester hydrolase significantly reduces atherosclerosis and lesion necrosis in Ldlr mice.Identification of a novel intracellular cholesteryl ester hydrolase (carboxylesterase 3) in human macrophages: compensatory increase in its expression after carboxylesterase 1 silencingExamination of the carboxylesterase phenotype in human liverStreptococcal serum opacity factor promotes cholesterol ester metabolism and bile acid secretion in vitro and in vivo.Inhibition of carboxylesterase 1 is associated with cholesteryl ester retention in human THP-1 monocyte/macrophages.Cooperation between hepatic cholesteryl ester hydrolase and scavenger receptor BI for hydrolysis of HDL-CELiver-specific cholesteryl ester hydrolase deficiency attenuates sterol elimination in the feces and increases atherosclerosis in ldlr-/- miceInhibition of carboxylesterase activity of THP1 monocytes/macrophages and recombinant human carboxylesterase 1 by oxysterols and fatty acids.Liver-specific transgenic expression of cholesteryl ester hydrolase reduces atherosclerosis in Ldlr-/- mice.Bolstering cholesteryl ester hydrolysis in liver: A hepatocyte-targeting gene delivery strategy for potential alleviation of atherosclerosis.Screening for drug-induced hepatotoxicity in primary mouse hepatocytes using acetaminophen, amiodarone, and cyclosporin a as model compounds: an omics-guided approach.Antioxidant sulforaphane and sensitizer trinitrobenzene sulfonate induce carboxylesterase-1 through a novel element transactivated by nuclear factor-E2 related factor-2.Intracellular cholesterol transport proteins enhance hydrolysis of HDL-CEs and facilitate elimination of cholesterol into bileMultisite promiscuity in the processing of endogenous substrates by human carboxylesterase 1.Hepatic carboxylesterase 1 is essential for both normal and farnesoid X receptor-controlled lipid homeostasis.Liver specific inactivation of carboxylesterase 3/triacylglycerol hydrolase decreases blood lipids without causing severe steatosis in mice.Sortilin 1 Modulates Hepatic Cholesterol Lipotoxicity in Mice via Functional Interaction with Liver Carboxylesterase 1.
P2860
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P2860
Human liver cholesteryl ester hydrolase: cloning, molecular characterization, and role in cellular cholesterol homeostasis.
description
2005 nî lūn-bûn
@nan
2005年の論文
@ja
2005年学术文章
@wuu
2005年学术文章
@zh-cn
2005年学术文章
@zh-hans
2005年学术文章
@zh-my
2005年学术文章
@zh-sg
2005年學術文章
@yue
2005年學術文章
@zh
2005年學術文章
@zh-hant
name
Human liver cholesteryl ester ...... lular cholesterol homeostasis.
@en
Human liver cholesteryl ester ...... lular cholesterol homeostasis.
@nl
type
label
Human liver cholesteryl ester ...... lular cholesterol homeostasis.
@en
Human liver cholesteryl ester ...... lular cholesterol homeostasis.
@nl
prefLabel
Human liver cholesteryl ester ...... lular cholesterol homeostasis.
@en
Human liver cholesteryl ester ...... lular cholesterol homeostasis.
@nl
P1476
Human liver cholesteryl ester ...... lular cholesterol homeostasis.
@en
P2093
Shobha Ghosh
P304
P356
10.1152/PHYSIOLGENOMICS.00187.2005
P577
2005-08-30T00:00:00Z