Niemann-Pick C1 Like 1 (NPC1L1) is the intestinal phytosterol and cholesterol transporter and a key modulator of whole-body cholesterol homeostasis.
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The structure of the NPC1L1 N-terminal domain in a closed conformationMembrane topology of human NPC1L1, a key protein in enterohepatic cholesterol absorptionThe hedgehog receptor patched is involved in cholesterol transportRequirement of myosin Vb.Rab11a.Rab11-FIP2 complex in cholesterol-regulated translocation of NPC1L1 to the cell surfaceFlotillins play an essential role in Niemann-Pick C1-like 1-mediated cholesterol uptake.NPC1L1 haplotype is associated with inter-individual variation in plasma low-density lipoprotein response to ezetimibeMechanisms and genetic determinants regulating sterol absorption, circulating LDL levels, and sterol elimination: implications for classification and disease riskIdentification of novel inhibitors of dietary lipid absorption using zebrafishSerine palmitoyltransferase (SPT) deficient mice absorb less cholesterolThe target of ezetimibe is Niemann-Pick C1-Like 1 (NPC1L1)The small GTPase Cdc42 interacts with Niemann-Pick C1-like 1 (NPC1L1) and controls its movement from endocytic recycling compartment to plasma membrane in a cholesterol-dependent mannerCD36 is important for fatty acid and cholesterol uptake by the proximal but not distal intestineCholesterol esterification by ACAT2 is essential for efficient intestinal cholesterol absorption: evidence from thoracic lymph duct cannulationNovel functions of PXR in cardiometabolic disease.Lupin protein isolate versus casein modifies cholesterol excretion and mRNA expression of intestinal sterol transporters in a pig modelProteins that bind and move lipids: MsbA and NPC1.Plant sterols cause macrothrombocytopenia in a mouse model of sitosterolemia.Sitosterolemia: diagnosis, investigation, and management.Opposing Gatekeepers of Apical Sterol Transport: Niemann-Pick C1-Like 1 (NPC1L1) and ATP-Binding Cassette Transporters G5 and G8 (ABCG5/ABCG8)Decreased NPC1L1 expression in the liver from Chinese female gallstone patientsHypercholesterolemia induces angiogenesis and accelerates growth of breast tumors in vivo.Food Ingredients That Inhibit Cholesterol Absorption.Acceleration of biliary cholesterol secretion restores glycemic control and alleviates hypertriglyceridemia in obese db/db mice.Impact of dietary fat type within the context of altered cholesterol homeostasis on cholesterol and lipoprotein metabolism in the F1B hamster.A human-type nonalcoholic steatohepatitis model with advanced fibrosis in rabbitsNPC1L1 and cholesterol transportTargets for current pharmacologic therapy in cholesterol gallstone disease.Dietary cholesterol reverses resistance to diet-induced weight gain in mice lacking Niemann-Pick C1-Like 1.Genetic interactions between chromosomes 11 and 18 contribute to airway hyperresponsiveness in miceImpact of circulating cholesterol levels on growth and intratumoral androgen concentration of prostate tumorsC57Bl/6 N mice on a western diet display reduced intestinal and hepatic cholesterol levels despite a plasma hypercholesterolemiaNiemann-Pick C1-Like 1 deletion in mice prevents high-fat diet-induced fatty liver by reducing lipogenesis.Cholesterol intake modulates plasma triglyceride levels in glycosylphosphatidylinositol HDL-binding protein 1-deficient mice.Identification of the Niemann-Pick C1-like 1 cholesterol absorption receptor as a new hepatitis C virus entry factor.An ileal Crohn's disease gene signature based on whole human genome expression profiles of disease unaffected ileal mucosal biopsiesEfficacy, safety and tolerability of ongoing statin plus ezetimibe versus doubling the ongoing statin dose in hypercholesterolemic Taiwanese patients: an open-label, randomized clinical trialEffect of ezetimibe on incretin secretion in response to the intestinal absorption of a mixed meal.Multiple mechanisms limit the accumulation of unesterified cholesterol in the small intestine of mice deficient in both ACAT2 and ABCA1.Reduced cholesterol absorption upon PPARdelta activation coincides with decreased intestinal expression of NPC1L1.Multiple rare variants in NPC1L1 associated with reduced sterol absorption and plasma low-density lipoprotein levels
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P2860
Niemann-Pick C1 Like 1 (NPC1L1) is the intestinal phytosterol and cholesterol transporter and a key modulator of whole-body cholesterol homeostasis.
description
2004 nî lūn-bûn
@nan
2004年の論文
@ja
2004年学术文章
@wuu
2004年学术文章
@zh-cn
2004年学术文章
@zh-hans
2004年学术文章
@zh-my
2004年学术文章
@zh-sg
2004年學術文章
@yue
2004年學術文章
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2004年學術文章
@zh-hant
name
Niemann-Pick C1 Like 1 (NPC1L1 ...... -body cholesterol homeostasis.
@en
type
label
Niemann-Pick C1 Like 1 (NPC1L1 ...... -body cholesterol homeostasis.
@en
prefLabel
Niemann-Pick C1 Like 1 (NPC1L1 ...... -body cholesterol homeostasis.
@en
P2093
P356
P1476
Niemann-Pick C1 Like 1 (NPC1L1 ...... -body cholesterol homeostasis.
@en
P2093
Erik G Lund
Glen Tetzloff
Harry R Davis
Jianjun Liu
Lizbeth M Hoos
Maureen Maguire
Michael P Graziano
My-Hanh Lam
Patricia A Detmers
P304
33586-33592
P356
10.1074/JBC.M405817200
P407
P577
2004-06-01T00:00:00Z