Somatic evolution of diversity among anti-phosphocholine antibodies induced with Proteus morganii.
about
Generation and analysis of random point mutations in an antibody CDR2 sequence: many mutated antibodies lose their ability to bind antigenImmunoglobulin heavy chain gene expression in peripheral blood B lymphocytes.Independently derived murine glomerular immune deposit-forming anti-DNA antibodies are encoded by near-identical VH gene sequencesIsolation of germinal centerlike events from human spleen RNA. Somatic hypermutation of a clonally related VH6DJH rearrangement expressed with IgM, IgG, and IgA.Silent development of memory progenitor B cellsSignificant structural and functional change of an antigen-binding site by a distant amino acid substitution: proposal of a structural mechanism.Structural characterization and MHCII-dependent immunological properties of the zwitterionic O-chain antigen of Morganella morganii.Primary structure of the variable region of monoclonal antibody 2B10, capable of inducing anti-idiotypic antibodies that recognize the C-terminal region of MSA-1 of Plasmodium falciparum.Characterization of somatically mutated S107 VH11-encoded anti-DNA autoantibodies derived from autoimmune (NZB x NZW)F1 mice.Antigen binding and idiotype analysis of antibodies obtained after electroporation of heavy and light chain genes encoding phosphocholine-specific antibodies: a model for T15-idiotype dominance.Clonal analysis of a human antibody response. II. Sequences of the VH genes of human IgM, IgG, and IgA to rabies virus reveal preferential utilization of VHIII segments and somatic hypermutationHeavy-chain class switch does not terminate somatic mutation.Boundaries of somatic mutation in rearranged immunoglobulin genes: 5' boundary is near the promoter, and 3' boundary is approximately 1 kb from V(D)J gene.Mutational hot spots in Ig V region genes of human follicular lymphomasRelationship of variable region genes expressed by a human B cell lymphoma secreting pathologic anti-Pr2 erythrocyte autoantibodies.Early onset of somatic mutation in immunoglobulin VH genes during the primary immune responseEvolution of antibody structure during the immune response. The differentiative potential of a single B lymphocyte.Molecular analysis of original antigenic sin. I. Clonal selection, somatic mutation, and isotype switching during a memory B cell responseRestricted kappa chain expression in early ontogeny: biased utilization of V kappa exons and preferential V kappa-J kappa recombinationsAntigen-driven B cell differentiation in vivoFacultative role of germinal centers and T cells in the somatic diversification of IgVH genesTracing the development of single memory-lineage B cells in a highly defined immune response.Use of Peyer's patch and lymph node fragment cultures to compare local immune responses to Morganella morganii.Clonal evolution of a follicular lymphoma: evidence for antigen selection.Sequencing heavy- and light-chain variable genes of single B-hybridoma cells by total enzymatic amplificationBoth mutated and unmutated memory B cells accumulate mutations in the course of the secondary response and develop a new antibody repertoire optimally adapted to the secondary stimulus.Mutation and selection during the secondary response to 2-phenyloxazolone.Restricted use of fetal VH3 immunoglobulin genes by unselected B cells in the adult. Predominance of 56p1-like VH genes in common variable immunodeficiency.Nucleotide sequences of the gene/cDNA coding for anti-murine erythrocyte autoantibody produced by a hybridoma from NZB mouseThe CDR1 sequences of a major proportion of human germline Ig VH genes are inherently susceptible to amino acid replacement.Somatic hypermutation of immunoglobulin kappa may depend on sequences 3' of C kappa and occurs on passenger transgenes.
P2860
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P2860
Somatic evolution of diversity among anti-phosphocholine antibodies induced with Proteus morganii.
description
1987 nî lūn-bûn
@nan
1987年の論文
@ja
1987年学术文章
@wuu
1987年学术文章
@zh
1987年学术文章
@zh-cn
1987年学术文章
@zh-hans
1987年学术文章
@zh-my
1987年学术文章
@zh-sg
1987年學術文章
@yue
1987年學術文章
@zh-hant
name
Somatic evolution of diversity ...... induced with Proteus morganii.
@en
Somatic evolution of diversity ...... induced with Proteus morganii.
@nl
type
label
Somatic evolution of diversity ...... induced with Proteus morganii.
@en
Somatic evolution of diversity ...... induced with Proteus morganii.
@nl
prefLabel
Somatic evolution of diversity ...... induced with Proteus morganii.
@en
Somatic evolution of diversity ...... induced with Proteus morganii.
@nl
P2093
P1476
Somatic evolution of diversity ...... induced with Proteus morganii.
@en
P2093
P304
P407
P577
1987-05-01T00:00:00Z