Evolution of antibody structure during the immune response. The differentiative potential of a single B lymphocyte.
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Isolation of germinal centerlike events from human spleen RNA. Somatic hypermutation of a clonally related VH6DJH rearrangement expressed with IgM, IgG, and IgA.Silent development of memory progenitor B cellsThe development of B cells and the B-cell repertoire in the microenvironment of the germinal center.Different epitope structures select distinct mutant forms of an antibody variable region for expression during the immune response.Characterization of somatically mutated S107 VH11-encoded anti-DNA autoantibodies derived from autoimmune (NZB x NZW)F1 mice.The role of clonal selection in the pathogenesis of an autoreactive human B cell lymphoma.Analysis of somatic mutations in kappa transgenes.Parallel evolution of antibody variable regions by somatic processes: consecutive shared somatic alterations in VH genes expressed by independently generated hybridomas apparently acquired by point mutation and selection rather than by gene conversiBoundaries of somatic mutation in rearranged immunoglobulin genes: 5' boundary is near the promoter, and 3' boundary is approximately 1 kb from V(D)J gene.Molecular analysis of original antigenic sin. I. Clonal selection, somatic mutation, and isotype switching during a memory B cell responseMolecular evolution of the human immunoglobulin E response: high incidence of shared mutations and clonal relatedness among epsilon VH5 transcripts from three unrelated patients with atopic dermatitisHypermutation is observed only in antibody H chain V region transgenes that have recombined with endogenous immunoglobulin H DNA: implications for the location of cis-acting elements required for somatic mutationAltering the antibody repertoire via transgene homologous recombination: evidence for global and clone-autonomous regulation of antigen-driven B cell differentiation.Tracing the development of single memory-lineage B cells in a highly defined immune response.The transcriptional promoter regulates hypermutation of the antibody heavy chain locus.Large-scale sequence and structural comparisons of human naive and antigen-experienced antibody repertoires.Conceptual bases for quantifying the role of the environment on gene evolution: the participation of positive selection and neutral evolution.Sequencing heavy- and light-chain variable genes of single B-hybridoma cells by total enzymatic amplificationSomatic recombination of heavy chain variable region transgenes with the endogenous immunoglobulin heavy chain locus in mice.The CDR1 sequences of a major proportion of human germline Ig VH genes are inherently susceptible to amino acid replacement.The involvement of adhesion molecules in the biology of multiple myeloma.The clonogenic precursor cell in multiple myeloma.Mutation pattern of immunoglobulin transgenes is compatible with a model of somatic hypermutation in which targeting of the mutator is linked to the direction of DNA replication.Two acquired immunodeficiency syndrome-associated Burkitt's lymphomas produce specific anti-i IgM cold agglutinins using somatically mutated VH4-21 segments.Somatic generation of hybrid antibody H chain genes in transgenic mice via interchromosomal gene conversion.Structural analysis of the VH-D-JH segments of human polyreactive IgG mAb. Evidence for somatic selection.The promotion of V region hypermutation.Somatic hypermutation of antibody genes: a hot spot warms up.Two Distinct Pathways in Mice Generate Antinuclear Antigen-Reactive B Cell Repertoires.The roles of antibody variable region hypermutation and selection in the development of the memory B-cell compartment.
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P2860
Evolution of antibody structure during the immune response. The differentiative potential of a single B lymphocyte.
description
1989 nî lūn-bûn
@nan
1989年の論文
@ja
1989年学术文章
@wuu
1989年学术文章
@zh-cn
1989年学术文章
@zh-hans
1989年学术文章
@zh-my
1989年学术文章
@zh-sg
1989年學術文章
@yue
1989年學術文章
@zh
1989年學術文章
@zh-hant
name
Evolution of antibody structur ...... tial of a single B lymphocyte.
@ast
Evolution of antibody structur ...... tial of a single B lymphocyte.
@en
type
label
Evolution of antibody structur ...... tial of a single B lymphocyte.
@ast
Evolution of antibody structur ...... tial of a single B lymphocyte.
@en
prefLabel
Evolution of antibody structur ...... tial of a single B lymphocyte.
@ast
Evolution of antibody structur ...... tial of a single B lymphocyte.
@en
P2860
P356
P1476
Evolution of antibody structur ...... tial of a single B lymphocyte.
@en
P2093
P2860
P304
P356
10.1084/JEM.170.4.1211
P407
P577
1989-10-01T00:00:00Z