Observed incidence of tumorigenesis in long-term rodent studies of rAAV vectors.
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Treatment of leber congenital amaurosis due to RPE65 mutations by ocular subretinal injection of adeno-associated virus gene vector: short-term results of a phase I trialAdeno-associated virus vector integrationGene therapy for mucopolysaccharidosisThe gene therapy journey for hemophilia: are we there yet?Animal models of hemophiliaLong-term correction of Sandhoff disease following intravenous delivery of rAAV9 to mouse neonatesComparative analysis of DNA nanoparticles and AAVs for ocular gene deliveryLessons Learned from Animal Models of Inherited Bleeding Disorders.Translational data from adeno-associated virus-mediated gene therapy of hemophilia B in dogsComplete correction of hyperphenylalaninemia following liver-directed, recombinant AAV2/8 vector-mediated gene therapy in murine phenylketonuria.Large-scale molecular characterization of adeno-associated virus vector integration in mouse liver.AAV provides an alternative for gene therapy of the peripheral sensory nervous system.Rescue of hereditary form of dilated cardiomyopathy by rAAV-mediated somatic gene therapy: amelioration of morphological findings, sarcolemmal permeability, cardiac performances, and the prognosis of TO-2 hamsters.AAV-mediated liver-directed gene therapy.Long-term systemic therapy of Fabry disease in a knockout mouse by adeno-associated virus-mediated muscle-directed gene transfer.rAAV-mediated tumorigenesis: still unresolved after an AAV assaultA limited number of transducible hepatocytes restricts a wide-range linear vector dose response in recombinant adeno-associated virus-mediated liver transductionAssessing the potential for AAV vector genotoxicity in a murine model.Transgene produces massive overexpression of human beta -glucuronidase in mice, lysosomal storage of enzyme, and strain-dependent tumors.Protein replacement therapy and gene transfer in canine models of hemophilia A, hemophilia B, von willebrand disease, and factor VII deficiency.AAV and compacted DNA nanoparticles for the treatment of retinal disorders: challenges and future prospects.Vector design influences hepatic genotoxicity after adeno-associated virus gene therapy.Safety of adeno-associated virus gene therapy vectors: a current evaluation.Long-term sex-biased correction of circulating propionic acidemia disease markers by adeno-associated virus vectors.Perinatal gene transfer to the liver.Advances in AAV-mediated gene transfer for the treatment of inherited disorders.Electrocardiographic and other cardiac anomalies in beta-glucuronidase-null mice corrected by nonablative neonatal marrow transplantationGene therapy for renal disorders.CNS-directed gene therapy for lysosomal storage diseasesA brain microvasculature endothelial cell-specific viral vector with the potential to treat neurovascular and neurological diseases.DNA palindromes with a modest arm length of greater, similar 20 base pairs are a significant target for recombinant adeno-associated virus vector integration in the liver, muscles, and heart in mice.Targeting site-specific chromosome integration.Patterns of scAAV vector insertion associated with oncogenic events in a mouse model for genotoxicityGenotoxicity in Mice Following AAV Gene Delivery: A Safety Concern for Human Gene Therapy?The state of the art of adeno-associated virus-based vectors in gene therapy.Gene therapy for inborn errors of liver metabolism: progress towards clinical applicationsLong-term correction of inhibitor-prone hemophilia B dogs treated with liver-directed AAV2-mediated factor IX gene therapy.Inherited diseases of photoreceptors and prospects for gene therapy.Potential of AAV vectors in the treatment of metabolic disease.Barriers for retinal gene therapy: separating fact from fiction.
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P2860
Observed incidence of tumorigenesis in long-term rodent studies of rAAV vectors.
description
2001 nî lūn-bûn
@nan
2001年の論文
@ja
2001年学术文章
@wuu
2001年学术文章
@zh
2001年学术文章
@zh-cn
2001年学术文章
@zh-hans
2001年学术文章
@zh-my
2001年学术文章
@zh-sg
2001年學術文章
@yue
2001年學術文章
@zh-hant
name
Observed incidence of tumorigenesis in long-term rodent studies of rAAV vectors.
@en
Observed incidence of tumorigenesis in long-term rodent studies of rAAV vectors.
@nl
type
label
Observed incidence of tumorigenesis in long-term rodent studies of rAAV vectors.
@en
Observed incidence of tumorigenesis in long-term rodent studies of rAAV vectors.
@nl
prefLabel
Observed incidence of tumorigenesis in long-term rodent studies of rAAV vectors.
@en
Observed incidence of tumorigenesis in long-term rodent studies of rAAV vectors.
@nl
P2093
P2860
P50
P356
P1433
P1476
Observed incidence of tumorigenesis in long-term rodent studies of rAAV vectors
@en
P2093
P2860
P2888
P304
P356
10.1038/SJ.GT.3301541
P577
2001-09-01T00:00:00Z