Crystal structures of the Apo and penicillin-acylated forms of the BlaR1 beta-lactam sensor of Staphylococcus aureus.
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Design, Synthesis, and Crystal Structures of 6-Alkylidene-2′-Substituted Penicillanic Acid Sulfones as Potent Inhibitors of Acinetobacter baumannii OXA-24 CarbapenemaseThree factors that modulate the activity of class D β-lactamases and interfere with the post-translational carboxylation of Lys70Lysine N -Decarboxylation Switch and Activation of the -Lactam Sensor Domain of BlaR1 Protein of Methicillin-resistant Staphylococcus aureusAn Amino Acid Position at Crossroads of Evolution of Protein Function: ANTIBIOTIC SENSOR DOMAIN OF BlaR1 PROTEIN FROM STAPHYLOCOCCUS AUREUS VERSUS CLASS D -LACTAMASESA Novel Family of Soluble Minimal Scaffolds Provides Structural Insight into the Catalytic Domains of Integral Membrane MetallopeptidasesCrystallographic analysis and biochemical applications of a novel penicillin-binding protein/β-lactamase homologue from a metagenomic libraryHost-guest chemistry of the peptidoglycanBacillus licheniformis BlaR1 L3 loop is a zinc metalloprotease activated by self-proteolysis.Discrete steps in sensing of beta-lactam antibiotics by the BlaR1 protein of the methicillin-resistant Staphylococcus aureus bacterium.Site-saturation mutagenesis of position V117 in OXA-1 β-lactamase: effect of side chain polarity on enzyme carboxylation and substrate turnover.Structure of the MecI repressor from Staphylococcus aureus in complex with the cognate DNA operator of mec.Mutation of the active site carboxy-lysine (K70) of OXA-1 beta-lactamase results in a deacylation-deficient enzyme.The different inhibition mechanisms of OXA-1 and OXA-24 β-lactamases are determined by the stability of active site carboxylated lysine.In silico serine β-lactamases analysis reveals a huge potential resistome in environmental and pathogenic species.Energy metabolism and drug efflux in Mycobacterium tuberculosisKey genetic elements and regulation systems in methicillin-resistant Staphylococcus aureus.Bacterial cell-wall recycling.Mechanisms of β-lactam killing and resistance in the context of Mycobacterium tuberculosis.Investigation of signal transduction routes within the sensor/transducer protein BlaR1 of Staphylococcus aureus.Dissection of events in the resistance to β-lactam antibiotics mediated by the protein BlaR1 from Staphylococcus aureus.Carboxylation and decarboxylation of active site Lys 84 controls the activity of OXA-24 β-lactamase of Acinetobacter baumannii: Raman crystallographic and solution evidence.13C-Carbamylation as a mechanistic probe for the inhibition of class D β-lactamases by avibactam and halide ions.A gratuitous β-Lactamase inducer uncovers hidden active site dynamics of the Staphylococcus aureus BlaR1 sensor domain.Genomic analysis of bifunctional Class C-Class D β-lactamases in environmental bacteria.Antibacterial Activity and Mechanism of Action of Aspidinol Against Multi-Drug-Resistant Methicillin-Resistant Staphylococcus aureus.Systematic Identification and Classification of β-Lactamases Based on Sequence Similarity Criteria: β-Lactamase Annotation
P2860
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P2860
Crystal structures of the Apo and penicillin-acylated forms of the BlaR1 beta-lactam sensor of Staphylococcus aureus.
description
2004 nî lūn-bûn
@nan
2004年の論文
@ja
2004年学术文章
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2004年学术文章
@zh-cn
2004年学术文章
@zh-hans
2004年学术文章
@zh-my
2004年学术文章
@zh-sg
2004年學術文章
@yue
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2004年學術文章
@zh-hant
name
Crystal structures of the Apo ...... nsor of Staphylococcus aureus.
@en
Crystal structures of the Apo ...... nsor of Staphylococcus aureus.
@nl
type
label
Crystal structures of the Apo ...... nsor of Staphylococcus aureus.
@en
Crystal structures of the Apo ...... nsor of Staphylococcus aureus.
@nl
prefLabel
Crystal structures of the Apo ...... nsor of Staphylococcus aureus.
@en
Crystal structures of the Apo ...... nsor of Staphylococcus aureus.
@nl
P2093
P2860
P356
P1476
Crystal structures of the Apo ...... nsor of Staphylococcus aureus.
@en
P2093
Henry F Chambers
Hong-Zhong Zhang
Mark S Wilke
Natalie C J Strynadka
Tanya L Hills
P2860
P304
47278-47287
P356
10.1074/JBC.M407054200
P407
P577
2004-08-18T00:00:00Z