Structure-activity relationships in engineered proteins: analysis of use of binding energy by linear free energy relationships.
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Using flexible loop mimetics to extend -value analysis to secondary structure interactionsStructural analysis and insights into the glycon specificity of the rice GH1 Os7BGlu26 β-D-mannosidaseAdditivity of protein-guanine interactions in ribonuclease T1Transition-state structure as a unifying basis in protein-folding mechanisms: contact order, chain topology, stability, and the extended nucleus mechanism.Initiation of RNA synthesis by the hepatitis C virus RNA-dependent RNA polymerase is affected by the structure of the RNA template.Design of highly stable functional GroEL minichaperones.Testing the Coulomb/Accessible Surface Area solvent model for protein stability, ligand binding, and protein design.A linkage analysis toolkit for studying allosteric networks in ion channels.Testing protein-folding simulations by experiment: B domain of protein A.Determinants of catalytic power and ligand binding in glutamate racemase.Three key residues form a critical contact network in a protein folding transition state.Structured pathway across the transition state for peptide folding revealed by molecular dynamics simulationsPhi-value analysis and the nature of protein-folding transition statesPlasticity of acetylcholine receptor gating motions via rate-energy relationships.Constrained proper sampling of conformations of transition state ensemble of protein folding.Protein engineering 20 years on.Mechanism of initiation of aggregation of p53 revealed by Φ-value analysisLinear rate-equilibrium relations arising from ion channel-bilayer energetic coupling.Delineation of a region in the B2 bradykinin receptor that is essential for high-affinity agonist binding.The effect of context on the folding of β-hairpins.A kinetically significant intermediate in the folding of barnase.Single versus parallel pathways of protein folding and fractional formation of structure in the transition stateLigand-specific roles for transmembrane 5 serine residues in the binding and efficacy of dopamine D(1) receptor catechol agonistsAn integrated catch-and-hold mechanism activates nicotinic acetylcholine receptors.Construction and properties of a temperature-sensitive mutation in the gene for the bacteriophage SPO1 DNA-binding protein TF1.Application of physical organic chemistry to engineered mutants of proteins: Hammond postulate behavior in the transition state of protein foldingStructural correlates of affinity in fetal versus adult endplate nicotinic receptorsA new direction for titin pulling.Toward the catalytic mechanism of a cysteine ligase (MshC) from Mycobacterium smegmatis: an enzyme involved in the biosynthetic pathway of mycothiol.Relationship of Leffler (Bronsted) alpha values and protein folding Phi values to position of transition-state structures on reaction coordinates.The effect of specific proline residues on the kinetic stability of the triosephosphate isomerases of two trypanosomes.Exploring multi-dimensional coordinate-dependent diffusion dynamics on the energy landscape of protein conformation change.Activation of D-tyrosine by Bacillus stearothermophilus tyrosyl-tRNA synthetase: 1. Pre-steady-state kinetic analysis reveals the mechanistic basis for the recognition of D-tyrosine.Generating properly weighted ensemble of conformations of proteins from sparse or indirect distance constraints.Mapping the conformational wave of acetylcholine receptor channel gating.The sixth Datta Lecture. Protein folding and stability: the pathway of folding of barnase.Evidence from a mutant beta-lactamase for the mechanism of beta-lactamase-catalysed depsipeptide aminolysis.The role of the turn in beta-hairpin formation during WW domain folding.Functional characterization of leucine-specific domain 1 from eukaryal and archaeal leucyl-tRNA synthetases.Nonfixed relationship of the Michaelis constant and maximum velocity with their corresponding rate constants.
P2860
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P2860
Structure-activity relationships in engineered proteins: analysis of use of binding energy by linear free energy relationships.
description
1987 nî lūn-bûn
@nan
1987年の論文
@ja
1987年学术文章
@wuu
1987年学术文章
@zh
1987年学术文章
@zh-cn
1987年学术文章
@zh-hans
1987年学术文章
@zh-my
1987年学术文章
@zh-sg
1987年學術文章
@yue
1987年學術文章
@zh-hant
name
Structure-activity relationshi ...... ear free energy relationships.
@en
Structure-activity relationshi ...... ear free energy relationships.
@nl
type
label
Structure-activity relationshi ...... ear free energy relationships.
@en
Structure-activity relationshi ...... ear free energy relationships.
@nl
prefLabel
Structure-activity relationshi ...... ear free energy relationships.
@en
Structure-activity relationshi ...... ear free energy relationships.
@nl
P356
P1433
P1476
Structure-activity relationshi ...... ear free energy relationships.
@en
P2093
P304
P356
10.1021/BI00393A013
P407
P577
1987-09-01T00:00:00Z