L-663,536 (MK-886) (3-[1-(4-chlorobenzyl)-3-t-butyl-thio-5-isopropylindol-2-yl]-2,2 - dimethylpropanoic acid), a novel, orally active leukotriene biosynthesis inhibitor.
about
Growth control of lung cancer by interruption of 5-lipoxygenase-mediated growth factor signalingThe molecular mechanism of the inhibition by licofelone of the biosynthesis of 5-lipoxygenase productsProduction of leukotrienes in a model of focal cerebral ischaemia in the ratSimilar coronary vascular effects in the rat perfused heart of platelet-activating factor structural analogues with agonist and antagonist propertiesLeukotriene D4 is a mediator of proteinuria and glomerular hemodynamic abnormalities in passive Heymann nephritis.LTB4 is a signal-relay molecule during neutrophil chemotaxisLipoxin A4 modulates transmigration of human neutrophils across intestinal epithelial monolayersRemodeling of neutrophil phospholipids with 15(S)-hydroxyeicosatetraenoic acid inhibits leukotriene B4-induced neutrophil migration across endothelium.Do infiltrating neutrophils contribute to the pathogenesis of indomethacin induced ulceration of the rat gastric antrum?Leukotrienes are involved in leukocyte recruitment induced by live Histoplasma capsulatum or by the beta-glucan present in their cell wallLeukotriene biosynthesis inhibition ameliorates acute lung injury following hemorrhagic shock in ratsDo eicosanoids cause colonic dysfunction in experimental E coli O157:H7 (EHEC) infection?Roles of tumor necrosis factor alpha, granulocyte-macrophage colony-stimulating factor, platelet-activating factor, and arachidonic acid metabolites in interleukin-1-induced resistance to infection in neutropenic micePhenotyping drug polypharmacology via eicosanoid profiling of blood.Inhibitory effects of MK-886 on arachidonic acid metabolism in human phagocytes15-Lipoxygenases regulate the production of chemokines in human lung macrophages.The importance of leukotrienes in airway inflammation in a mouse model of asthma.Collagen-induced arthritis is reduced in 5-lipoxygenase-activating protein-deficient miceLeukotriene biosynthesis inhibitor MK886 impedes DNA polymerase activity.Role of oxygen radicals and arachidonic acid metabolites in the reverse passive Arthus reaction and carrageenin paw oedema in the ratCellular oxidative modification of low density lipoprotein does not require lipoxygenases.Effects of thyroid hormone analogue and a leukotrienes pathway-blocker on reperfusion injury attenuation after heart transplantation.Leukotriene D4 activates a chloride conductance in hepatocytes from lipopolysaccharide-treated rats.Androgen-mediated sex bias impairs efficiency of leukotriene biosynthesis inhibitors in males.Myrtucommulone, a natural acylphloroglucinol, inhibits microsomal prostaglandin E(2) synthase-1Role of leukotrienes in leukocyte adhesion following systemic administration of oxidatively modified human low density lipoprotein in hamsters.Leukotrienes as mediators in ischemia-reperfusion injury in a microcirculation model in the hamster.Blockade of endogenous leukotrienes exacerbates pulmonary histoplasmosis.Pharmacological profile and efficiency in vivo of diflapolin, the first dual inhibitor of 5-lipoxygenase-activating protein and soluble epoxide hydrolase.Modulation of cellular phospholipid fatty acids and leukotriene B4 synthesis in the human intestinal cell (CaCo-2).Pharmacokinetic and pharmacodynamic analysis of a novel leukotriene biosynthesis inhibitor, MK-0591, in healthy volunteers.Discovery of the first dual inhibitor of the 5-lipoxygenase-activating protein and soluble epoxide hydrolase using pharmacophore-based virtual screeningInteraction of vasoactive substances released by platelet-activating factor in the rat perfused heart.Nitric oxide and arachidonic acid modulation of calcium currents in postganglionic neurones of avian cultured ciliary ganglia.Mechanical stretch reveals different components of endothelial-mediated vascular tone in rat aortic strips.The cytotoxic activity of Bacillus anthracis lethal factor is inhibited by leukotriene A4 hydrolase and metallopeptidase inhibitors.A natural protective mechanism against hyperglycaemia in vascular endothelial and smooth-muscle cells: role of glucose and 12-hydroxyeicosatetraenoic acid.Mechanisms of the coronary vascular effects of platelet-activating factor in the rat perfused heart.Study of the effector mechanism involved in the production of haemorrhagic necrosis of the small intestine in rat passive anaphylaxis.Formation of sulphidopeptide-leukotrienes by cell-cell interaction causes coronary vasoconstriction in isolated, cell-perfused heart of rabbit
P2860
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P2860
L-663,536 (MK-886) (3-[1-(4-chlorobenzyl)-3-t-butyl-thio-5-isopropylindol-2-yl]-2,2 - dimethylpropanoic acid), a novel, orally active leukotriene biosynthesis inhibitor.
description
1989 nî lūn-bûn
@nan
1989年の論文
@ja
1989年学术文章
@wuu
1989年学术文章
@zh
1989年学术文章
@zh-cn
1989年学术文章
@zh-hans
1989年学术文章
@zh-my
1989年学术文章
@zh-sg
1989年學術文章
@yue
1989年學術文章
@zh-hant
name
L-663,536 (MK-886) (3-[1-(4-ch ...... triene biosynthesis inhibitor.
@en
L-663,536 (MK-886) (3-[1-(4-ch ...... triene biosynthesis inhibitor.
@nl
type
label
L-663,536 (MK-886) (3-[1-(4-ch ...... triene biosynthesis inhibitor.
@en
L-663,536 (MK-886) (3-[1-(4-ch ...... triene biosynthesis inhibitor.
@nl
prefLabel
L-663,536 (MK-886) (3-[1-(4-ch ...... triene biosynthesis inhibitor.
@en
L-663,536 (MK-886) (3-[1-(4-ch ...... triene biosynthesis inhibitor.
@nl
P2093
P1476
L-663,536 (MK-886) (3-[1-(4-ch ...... triene biosynthesis inhibitor.
@en
P2093
A W Ford-Hutchinson
C S McFarlane
S Charleson
P304
P577
1989-05-01T00:00:00Z