The Tie-2 ligand angiopoietin-2 destabilizes quiescent endothelium through an internal autocrine loop mechanism.
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Multiple angiopoietin recombinant proteins activate the Tie1 receptor tyrosine kinase and promote its interaction with Tie2Angiopoietin 2 is a partial agonist/antagonist of Tie2 signaling in the endotheliumAnti-angiogenic alternatives to VEGF blockadeMechanisms regulating endothelial permeabilityMoving Past Anti-VEGF: Novel Therapies for Treating Diabetic RetinopathyTranscriptional and posttranscriptional regulation of angiopoietin-2 expression mediated by IGF and PDGF in vascular smooth muscle cellsCirculating angiopoietin-2 as a biomarker in ANCA-associated vasculitisDevelopment of the renal arterioles.Angiopoietin-2 stimulation of endothelial cells induces alphavbeta3 integrin internalization and degradationAngiopoietin-2 differentially regulates angiogenesis through TIE2 and integrin signaling.Ratio of angiopoietin-2 to angiopoietin-1 as a predictor of mortality in acute lung injury patients.Recapitulating physiological and pathological shear stress and oxygen to model vasculature in health and disease.Serum Concentrations of Angiopoietin-2 and Soluble fms-Like Tyrosine Kinase 1 (sFlt-1) Are Associated with Coagulopathy among Patients with Acute Pancreatitis.Molecular mediators of angiogenesis.Expression and localization of angiogenic growth factors in developing porcine mesonephric glomeruli.Resistance to antiangiogenic therapy is directed by vascular phenotype, vessel stabilization, and maturation in malignant melanoma.Tie2 as a novel key factor of microangiopathy in systemic sclerosis.Angiogenesis-related biomarkers in patients with alcoholic liver disease: their association with liver disease complications and outcome.Angiopoietin-2: development of inhibitors for cancer therapy.Angiopoietin-2 in experimental colitisOpposing effects of the angiopoietins on the thrombin-induced permeability of human pulmonary microvascular endothelial cells.Angiopoietin-2 is a potential mediator of endothelial barrier dysfunction following cardiopulmonary bypass.The role of angiogenic factors in predicting clinical outcome in severe bacterial infection in Malawian children.Angiopoietin-2 confers Atheroprotection in apoE-/- mice by inhibiting LDL oxidation via nitric oxide.VEGF-mediated fusion in the generation of uniluminal vascular spheroidsVasculotide, an Angiopoietin-1 mimetic, reduces acute skin ionizing radiation damage in a preclinical mouse model.A modular approach to cardiac tissue engineering.Identification of serum angiopoietin-2 as a biomarker for clinical outcome of colorectal cancer patients treated with bevacizumab-containing therapyMurine rVEGF164b, an inhibitory VEGF reduces VEGF-A-dependent endothelial proliferation and barrier dysfunction.Early vessel destabilization mediated by Angiopoietin-2 and subsequent vessel maturation via Angiopoietin-1 induce functional neovasculature after ischemia.Angiopoietin-2 is critical for cytokine-induced vascular leakageAngiopoietin-2 functions as an autocrine protective factor in stressed endothelial cells.Heterogeneity of Tie2 expression in tumor microcirculation: influence of cancer type, implantation site, and response to therapy.Targeting vascular pericytes in hypoxic tumors increases lung metastasis via angiopoietin-2.Role of the angiopoietin/Tie system in pregnancy (Review).Anti-vascular therapies in ovarian cancer: moving beyond anti-VEGF approaches.Alternative vascularization mechanisms in cancer: Pathology and therapeutic implications.Drug Repurposing Screen Identifies Foxo1-Dependent Angiopoietin-2 Regulation in Sepsis.Inhibition of endothelial/smooth muscle cell contact loss by the investigational angiopoietin-2 antibody MEDI3617.Endothelial permeability following coronary artery bypass grafting: an observational study on the possible role of angiopoietin imbalance.
P2860
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P2860
The Tie-2 ligand angiopoietin-2 destabilizes quiescent endothelium through an internal autocrine loop mechanism.
description
2005 nî lūn-bûn
@nan
2005年の論文
@ja
2005年学术文章
@wuu
2005年学术文章
@zh-cn
2005年学术文章
@zh-hans
2005年学术文章
@zh-my
2005年学术文章
@zh-sg
2005年學術文章
@yue
2005年學術文章
@zh
2005年學術文章
@zh-hant
name
The Tie-2 ligand angiopoietin- ...... rnal autocrine loop mechanism.
@en
The Tie-2 ligand angiopoietin- ...... rnal autocrine loop mechanism.
@nl
type
label
The Tie-2 ligand angiopoietin- ...... rnal autocrine loop mechanism.
@en
The Tie-2 ligand angiopoietin- ...... rnal autocrine loop mechanism.
@nl
prefLabel
The Tie-2 ligand angiopoietin- ...... rnal autocrine loop mechanism.
@en
The Tie-2 ligand angiopoietin- ...... rnal autocrine loop mechanism.
@nl
P2093
P356
P1476
The Tie-2 ligand angiopoietin- ...... rnal autocrine loop mechanism.
@en
P2093
Marion Scharpfenecker
Ulrike Fiedler
Yvonne Reiss
P304
P356
10.1242/JCS.01653
P407
P577
2005-02-01T00:00:00Z