The thioredoxin-1 inhibitor 1-methylpropyl 2-imidazolyl disulfide (PX-12) decreases vascular permeability in tumor xenografts monitored by dynamic contrast enhanced magnetic resonance imaging.
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Improving tumour heterogeneity MRI assessment with histograms.APE1/Ref-1 regulates STAT3 transcriptional activity and APE1/Ref-1-STAT3 dual-targeting effectively inhibits pancreatic cancer cell survivalImaging hemodynamics.Redox-sensitive contrast agents for MRI based on reversible binding of thiols to serum albumin.The antitumor thioredoxin-1 inhibitor PX-12 (1-methylpropyl 2-imidazolyl disulfide) decreases thioredoxin-1 and VEGF levels in cancer patient plasmaApplication of a biodegradable macromolecular contrast agent in dynamic contrast-enhanced MRI for assessing the efficacy of indocyanine green-enhanced photothermal cancer therapy.Tumor characterization with dynamic contrast enhanced magnetic resonance imaging and biodegradable macromolecular contrast agents in miceThioredoxin-1 inhibitor PX-12 induces human acute myeloid leukemia cell apoptosis and enhances the sensitivity of cells to arsenic trioxideKEAP1-dependent synthetic lethality induced by AKT and TXNRD1 inhibitors in lung cancerAntitumor agent PX-12 inhibits HIF-1α protein levels through an Nrf2/PMF-1-mediated increase in spermidine/spermine acetyl transferase.Over-expression of Thioredoxin-1 mediates growth, survival, and chemoresistance and is a druggable target in diffuse large B-cell lymphoma.Ectopic expression of human MutS homologue 2 on renal carcinoma cells is induced by oxidative stress with interleukin-18 promotion via p38 mitogen-activated protein kinase (MAPK) and c-Jun N-terminal kinase (JNK) signaling pathways.Reactive aldehyde modification of thioredoxin-1 activates early steps of inflammation and cell adhesionImaging biomarkers to monitor response to the hypoxia-activated prodrug TH-302 in the MiaPaCa2 flank xenograft model.A reference agent model for DCE MRI can be used to quantify the relative vascular permeability of two MRI contrast agents.Characterization of tumor angiogenesis with dynamic contrast-enhanced MRI and biodegradable macromolecular contrast agents in mice.A phase IB trial of 24-hour intravenous PX-12, a thioredoxin-1 inhibitor, in patients with advanced gastrointestinal cancersDevelopment of Inhibitors Targeting Hypoxia-Inducible Factor 1 and 2 for Cancer Therapy.Polydisulfide Based Biodegradable Macromolecular Magnetic Resonance Imaging Contrast Agents.Stereochemical configuration of 4-hydroxy-2-nonenal-cysteine adducts and their stereoselective formation in a redox-regulated protein.Thioredoxin-1 protects against androgen receptor-induced redox vulnerability in castration-resistant prostate cancer.
P2860
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P2860
The thioredoxin-1 inhibitor 1-methylpropyl 2-imidazolyl disulfide (PX-12) decreases vascular permeability in tumor xenografts monitored by dynamic contrast enhanced magnetic resonance imaging.
description
2005 nî lūn-bûn
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2005年の論文
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2005年学术文章
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2005年学术文章
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name
The thioredoxin-1 inhibitor 1- ...... ed magnetic resonance imaging.
@en
The thioredoxin-1 inhibitor 1-methylpropyl 2-imidazolyl disulfide
@nl
type
label
The thioredoxin-1 inhibitor 1- ...... ed magnetic resonance imaging.
@en
The thioredoxin-1 inhibitor 1-methylpropyl 2-imidazolyl disulfide
@nl
prefLabel
The thioredoxin-1 inhibitor 1- ...... ed magnetic resonance imaging.
@en
The thioredoxin-1 inhibitor 1-methylpropyl 2-imidazolyl disulfide
@nl
P2093
P1476
The thioredoxin-1 inhibitor 1- ...... ced magnetic resonance imaging
@en
P2093
Amanda F Baker
Bénédicte F Jordan
Garth Powis
Matthew Runquist
Natarajan Raghunand
Wendy R Tate
P304
P407
P433
P577
2005-01-01T00:00:00Z