Metabolism of nicotine by human liver microsomes: stereoselective formation of trans-nicotine N'-oxide.
about
Beneficial effects of nicotine, cotinine and its metabolites as potential agents for Parkinson's diseaseMammalian flavin-containing monooxygenases: structure/function, genetic polymorphisms and role in drug metabolismNicotine chemistry, metabolism, kinetics and biomarkersA genetic polymorphism in coumarin 7-hydroxylation: sequence of the human CYP2A genes and identification of variant CYP2A6 allelesGenotyping of human cytochrome P450 2A6 (CYP2A6), a nicotine C-oxidasePolymorphisms of CYP2A6 and its practical consequencesNicotine induced pro-oxidant and antioxidant imbalance in rat lymphocytes: in vivo dose and time dependent approachesStructural features of cytochromes P450 and ligands that affect drug metabolism as revealed by X-ray crystallography and NMR.Summary of information on human CYP enzymes: human P450 metabolism data.Predicting drug interactions and pharmacokinetic variability with in vitro methods: the olanzapine experience.Role of CYP2A5 in the clearance of nicotine and cotinine: insights from studies on a Cyp2a5-null mouse modelA novel CYP2A6 allele, CYP2A6*23, impairs enzyme function in vitro and in vivo and decreases smoking in a population of Black-African descentNicotine metabolism in pregnant and nonpregnant rabbitsPharmacokinetics and molecular detoxicationHuman flavin-containing monooxygenase (form 3): polymorphisms and variations in chemical metabolism.Tobacco use and cessation among women: research and treatment-related issuesGene-centric analysis of serum cotinine levels in African and European American populations.Catalytic mechanism of cytochrome P450 for N-methylhydroxylation of nicotine: reaction pathways and regioselectivity of the enzymatic nicotine oxidation.The growing burden of chronic obstructive pulmonary disease and lung cancer in women: examining sex differences in cigarette smoke metabolism.Applications of CYP-450 expression for biomonitoring in environmental healthNicotine addiction causes unique detrimental effects on women's brains.Induction of cytochrome P450 enzymes: a view on human in vivo findings.Biotransformation and bioactivation reactions of alicyclic amines in drug molecules.In vitro methods for assessing human hepatic drug metabolism: their use in drug development.Stereoselectivity in S- and N-oxygenation by the mammalian flavin-containing and cytochrome P-450 monooxygenases.Fundamental reaction pathways for cytochrome P450-catalyzed 5'-hydroxylation and N-demethylation of nicotine.Effect of pregnancy on a measure of FMO3 activity.Effects of whole deletion of CYP2A6 on nicotine metabolism in humans.Molecular orbital calculations and nicotine metabolism: a rationale for experimentally observed metabolite ratios.Development of a CD-MEKC method for investigating the metabolism of tamoxifen by flavin-containing monooxygenases and the inhibitory effects of methimazole, nicotine and DMXAA.Effect of quercetin on nicotine-induced biochemical changes and DNA damage in rat peripheral blood lymphocytes.The impact of nicotine on bone healing and osseointegration.An In Silico Method for Screening Nicotine Derivatives as Cytochrome P450 2A6 Selective Inhibitors Based on Kernel Partial Least Squares.Behavioral changes after nicotine challenge are associated with α7 nicotinic acetylcholine receptor-stimulated glutamate release in the rat dorsal striatum.Longitudinal Influence of Pregnancy on Nicotine Metabolic Pathways.Substituted heteroaromatic compounds: effect on nicotine self-administration in rats.Microbial Flavoprotein Monooxygenases as Mimics of Mammalian Flavin-Containing Monooxygenases for the Enantioselective Preparation of Drug Metabolites.
P2860
Q21131066-BFE82C6A-C39D-4F53-8B62-639E7933B5EDQ22251223-5FE56779-2981-49D6-B4C5-AA9C615CFE9CQ24632647-31998F89-A203-4021-B16F-336FCEB29F2EQ24672583-8D2BB5FC-7524-4744-812F-D4E382FB6B81Q28289652-A1C2355F-C212-4AC4-907A-47F0BF602E0AQ28362536-013DCD53-9E19-4CD3-AD2A-D302F26E65ADQ28578479-66F63DEE-C332-401B-8E49-B557B729AA8BQ30396630-DFA722B8-7723-415C-B405-55980697CC0AQ32103802-4B4453DC-1ABA-4561-8AE3-CBF6FB0D2F4EQ33538218-0F47DA99-4082-46C0-9E10-8F6F83D3260FQ33613568-037FC424-55C1-4AF9-9363-441E572A39D1Q34020315-178A23EC-A47B-492E-A207-4A6674214E6DQ34071786-5220BC1D-4CA3-4C6F-AE80-FD56A2621036Q34636589-3383EED4-7E27-45EB-BFEB-780F2798F23FQ34673357-44DC6177-F9CE-44C8-AC52-0C57E0BC569FQ34684153-68BEF91D-CCF8-4ED6-9682-45273B4CCAB4Q35760246-A3BED946-4BE4-4F2C-BE1B-1E9F774171E0Q36747874-7D934319-B34A-4160-AD47-3B18DC955B1FQ36782636-302CC3FB-FA7C-4A1E-93D6-550B92835591Q37232322-C1B1C0A3-D19B-4285-9352-1A926123D3B6Q37864984-925AF259-F353-4B4F-9D8F-D24CA791D6B6Q38057372-D277872C-7C52-48F3-989B-6B8684174636Q38218540-BE55E9CF-4E65-403E-A3A0-6A83FBFFB2E4Q40817420-A31CC438-8D7B-46EF-8FC2-E4359F5A48ADQ40832872-0C707675-CB4E-414D-9015-569AE0B8B89AQ42086924-37228D31-81FC-47E8-A8E5-3D1E0DB53535Q42758707-3EF3AB3E-5DA1-4FA2-9049-F68895E219E7Q44002892-3FE6E5E3-F1F0-4D9B-8062-3AA3E1431C98Q44131947-8E409496-CEAE-47BD-B529-18D7C9CCE953Q45218281-829652F5-80E2-43C3-9D6E-818E8DC8E54EQ46364029-ECE5078E-F70C-4A69-9B92-C2D3D9B4DF32Q46475757-9F8DD3A7-79EF-4B38-B99F-42C62EEF4D90Q46731625-C310124A-989B-44D8-8F9E-31DE67CF8B10Q47096343-5F7C05CB-C3A1-46C2-8824-4B8F76A8D7AEQ47572401-19356074-E527-41E9-82BD-38C37C5621D3Q51828811-22291A90-2550-416C-AB74-2B15E106B319Q53625601-2A15C1DD-6FAF-4BB1-B997-5F5E5EB75460
P2860
Metabolism of nicotine by human liver microsomes: stereoselective formation of trans-nicotine N'-oxide.
description
1992 nî lūn-bûn
@nan
1992年の論文
@ja
1992年学术文章
@wuu
1992年学术文章
@zh
1992年学术文章
@zh-cn
1992年学术文章
@zh-hans
1992年学术文章
@zh-my
1992年学术文章
@zh-sg
1992年學術文章
@yue
1992年學術文章
@zh-hant
name
Metabolism of nicotine by huma ...... on of trans-nicotine N'-oxide.
@en
Metabolism of nicotine by huma ...... on of trans-nicotine N'-oxide.
@nl
type
label
Metabolism of nicotine by huma ...... on of trans-nicotine N'-oxide.
@en
Metabolism of nicotine by huma ...... on of trans-nicotine N'-oxide.
@nl
prefLabel
Metabolism of nicotine by huma ...... on of trans-nicotine N'-oxide.
@en
Metabolism of nicotine by huma ...... on of trans-nicotine N'-oxide.
@nl
P2093
P356
P1476
Metabolism of nicotine by huma ...... on of trans-nicotine N'-oxide.
@en
P2093
P304
P356
10.1021/TX00029A008
P577
1992-09-01T00:00:00Z