Rapid apoptosis induction by IGFBP-3 involves an insulin-like growth factor-independent nucleomitochondrial translocation of RXRalpha/Nur77.
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Identification of a novel cell death receptor mediating IGFBP-3-induced anti-tumor effects in breast and prostate cancerUnraveling insulin-like growth factor binding protein-3 actions in human diseaseRegulation of multiple insulin-like growth factor binding protein genes by 1alpha,25-dihydroxyvitamin D3.Human conditions of insulin-like growth factor-I (IGF-I) deficiencyAn ocular view of the IGF-IGFBP systemNuclear actions of insulin-like growth factor binding protein-3Potentiation of growth factor signaling by insulin-like growth factor-binding protein-3 in breast epithelial cells requires sphingosine kinase activitySignal Transduction Pathways Mediated by Secreted and Non-secreted Forms of intact Insulin-like Growth Factor Binding Protein-3 (IGFBP-3) and its 1-97 N-terminal Fragment in PC-3 Human Prostate Cancer CellsIGFBP3 colocalizes with and regulates hypocretin (orexin)Interaction of insulin-like growth factor-binding protein-3 and BAX in mitochondria promotes male germ cell apoptosis.Apigenin Modulates Insulin-like Growth Factor Axis: Implications for Prevention and Therapy of Prostate Cancer.Regulation of retinal endothelial cell apoptosis through activation of the IGFBP-3 receptor.Maintenance of naïve CD8 T cells in nonagenarians by leptin, IGFBP3 and T3.Overexpression of SphK2 contributes to ATRA resistance in colon cancer through rapid degradation of cytoplasmic RXRα by K48/K63-linked polyubiquitinationR1507, an anti-insulin-like growth factor-1 receptor (IGF-1R) antibody, and EWS/FLI-1 siRNA in Ewing's sarcoma: convergence at the IGF/IGFR/Akt axisThe role of insulin-like growth factor-I and its binding proteins in glucose homeostasis and type 2 diabetes.NRF2, cancer and calorie restrictionProtection of blood retinal barrier and systemic vasculature by insulin-like growth factor binding protein-3.Modulation of the growth hormone-insulin-like growth factor (GH-IGF) axis by pharmaceutical, nutraceutical and environmental xenobiotics: an emerging role for xenobiotic-metabolizing enzymes and the transcription factors regulating their expression.Proteome-wide analysis reveals an age-associated cellular phenotype of in situ aged human fibroblasts.Targeting Nur77 translocation.ERK1/2 deactivation enhances cytoplasmic Nur77 expression level and improves the apoptotic effect of fenretinide in human liver cancer cellsAssociations of insulin-like growth factor (IGF)-I and IGF-binding protein-3 with HIV disease progression in women.IGFBP-3 is a metastasis suppression gene in prostate cancerNuclear export and mitochondrial and endoplasmic reticulum localization of IGF-binding protein 3 regulate its apoptotic properties.Expression of insulin-like growth factor binding protein-3 in pterygium tissue.A novel form of chondrocyte stress is triggered by a COMP mutation causing pseudoachondroplasia.Elevated IGFBP3 levels in diabetic tears: a negative regulator of IGF-1 signaling in the corneal epithelium.IGFBP-3 may trigger osteoarthritis by inducing apoptosis of chondrocytes through Nur77 translocationIGF binding protein-3 regulates hematopoietic stem cell and endothelial precursor cell function during vascular development.A possible molecular mechanism of hearing loss during cerebral ischemia in miceTargeting truncated RXRα for cancer therapy.Involvement of p53 in insulin-like growth factor binding protein-3 regulation in the breast cancer cell response to DNA damage.The insulin-like growth factor system in chronic kidney disease: Pathophysiology and therapeutic opportunities.Nimotuzumab promotes radiosensitivity of EGFR-overexpression esophageal squamous cell carcinoma cells by upregulating IGFBP-3.During negative selection, Nur77 family proteins translocate to mitochondria where they associate with Bcl-2 and expose its proapoptotic BH3 domain.Histone deacetylase inhibitors enhance the apoptotic activity of insulin-like growth factor binding protein-3 by blocking PKC-induced IGFBP-3 degradationInsulin-like growth factor binding protein-3 (IGFBP-3): Novel ligands mediate unexpected functions.Assessing the clinical utility of measuring Insulin-like Growth Factor Binding Proteins in tissues and sera of melanoma patientsHypoxia Suppresses Spontaneous Mineralization and Osteogenic Differentiation of Mesenchymal Stem Cells via IGFBP3 Up-Regulation.
P2860
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P2860
Rapid apoptosis induction by IGFBP-3 involves an insulin-like growth factor-independent nucleomitochondrial translocation of RXRalpha/Nur77.
description
2005 nî lūn-bûn
@nan
2005年の論文
@ja
2005年学术文章
@wuu
2005年学术文章
@zh
2005年学术文章
@zh-cn
2005年学术文章
@zh-hans
2005年学术文章
@zh-my
2005年学术文章
@zh-sg
2005年學術文章
@yue
2005年學術文章
@zh-hant
name
Rapid apoptosis induction by I ...... anslocation of RXRalpha/Nur77.
@en
Rapid apoptosis induction by I ...... anslocation of RXRalpha/Nur77.
@nl
type
label
Rapid apoptosis induction by I ...... anslocation of RXRalpha/Nur77.
@en
Rapid apoptosis induction by I ...... anslocation of RXRalpha/Nur77.
@nl
prefLabel
Rapid apoptosis induction by I ...... anslocation of RXRalpha/Nur77.
@en
Rapid apoptosis induction by I ...... anslocation of RXRalpha/Nur77.
@nl
P2093
P2860
P356
P1476
Rapid apoptosis induction by I ...... anslocation of RXRalpha/Nur77.
@en
P2093
Bingrong Liu
Kuk-Wha Lee
Pinchas Cohen
Xiao-kun Zhang
Xinmin Yan
P2860
P304
16942-16948
P356
10.1074/JBC.M412757200
P407
P577
2005-02-24T00:00:00Z