about
Fluid-phase pinocytosis of native low density lipoprotein promotes murine M-CSF differentiated macrophage foam cell formationMal connects TLR2 to PI3Kinase activation and phagocyte polarizationA central role for DOCK2 during interstitial lymphocyte motility and sphingosine-1-phosphate-mediated egressPKCβ phosphorylates PI3Kγ to activate it and release it from GPCR controlSequential activation of class IB and class IA PI3K is important for the primed respiratory burst of human but not murine neutrophilsThe Ras/Rac1/Cdc42/SEK/JNK/c-Jun cascade is a key pathway by which agonists stimulate DNA synthesis in primary cultures of rat hepatocytesGABAA receptor-associated phosphoinositide 3-kinase is required for insulin-induced recruitment of postsynaptic GABAA receptorsPhosphatidylinositol 3-kinase regulates the CD4/CD8 T cell differentiation ratioRas is an indispensable coregulator of the class IB phosphoinositide 3-kinase p87/p110gammaDeconvolution of Buparlisib's mechanism of action defines specific PI3K and tubulin inhibitors for therapeutic intervention.PI3K p110γ deletion attenuates murine atherosclerosis by reducing macrophage proliferation but not polarization or apoptosis in lesions.Essential role of the p110beta subunit of phosphoinositide 3-OH kinase in male fertility.Plasmin inhibitors prevent leukocyte accumulation and remodeling events in the postischemic microvasculature.Central role for G protein-coupled phosphoinositide 3-kinase gamma in inflammation.Phosphoinositide 3-kinase signalling: no lipids.Membrane transport in Caenorhabditis elegans: an essential role for VPS34 at the nuclear membrane.Targeting PI3Kγ activity decreases vascular trauma-induced intimal hyperplasia through modulation of the Th1 response.Loss of phosphatase activity in myotubularin-related protein 2 is associated with Charcot-Marie-Tooth disease type 4B1.Chemical development of intracellular protein heterodimerizers.PI3Kγ within a nonhematopoietic cell type negatively regulates diet-induced thermogenesis and promotes obesity and insulin resistance.Murine bone marrow-derived macrophages differentiated with GM-CSF become foam cells by PI3Kγ-dependent fluid-phase pinocytosis of native LDL.Negative feedback regulation of Rac in leukocytes from mice expressing a constitutively active phosphatidylinositol 3-kinase gamma.Phosphoinositide 3-kinase gamma participates in T cell receptor-induced T cell activation.Lipid signalling in disease.PI3Ks-drug targets in inflammation and cancer.PI3Kγ activity in leukocytes promotes adipose tissue inflammation and early-onset insulin resistance during obesity.Integrating cardiac PIP3 and cAMP signaling through a PKA anchoring function of p110γ.Targeting PI3K in neuroblastoma.Regulation of myocardial contractility and cell size by distinct PI3K-PTEN signaling pathways.The forkhead transcription factor FOXO3a increases phosphoinositide-3 kinase/Akt activity in drug-resistant leukemic cells through induction of PIK3CA expressionDefective dendritic cell migration and activation of adaptive immunity in PI3Kgamma-deficient mice.Living with lethal PIP3 levels: viability of flies lacking PTEN restored by a PH domain mutation in Akt/PKB.Activation loop sequences confer substrate specificity to phosphoinositide 3-kinase alpha (PI3Kalpha ). Functions of lipid kinase-deficient PI3Kalpha in signaling.Lipid kinase and protein kinase activities of G-protein-coupled phosphoinositide 3-kinase gamma: structure-activity analysis and interactions with wortmannin.Cell-permeant and photocleavable chemical inducer of dimerization.Corresponding oscillations in neutrophil shape and filamentous actin content.The mitogen-activated protein (MAP) kinase cascade can either stimulate or inhibit DNA synthesis in primary cultures of rat hepatocytes depending upon whether its activation is acute/phasic or chronic.Wortmannin is a potent phosphatidylinositol 3-kinase inhibitor: the role of phosphatidylinositol 3,4,5-trisphosphate in neutrophil responses.5-(4,6-Dimorpholino-1,3,5-triazin-2-yl)-4-(trifluoromethyl)pyridin-2-amine (PQR309), a Potent, Brain-Penetrant, Orally Bioavailable, Pan-Class I PI3K/mTOR Inhibitor as Clinical Candidate in Oncology.Staurosporine inhibits the respiratory burst and induces exocytosis in human neutrophils.
P50
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P50
description
hulumtues
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researcher
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ricercatore
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wetenschapper
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հետազոտող
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Matthias P Wymann
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Matthias P Wymann
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Matthias P Wymann
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Matthias P Wymann
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Matthias P Wymann
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Matthias P Wymann
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Matthias P Wymann
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Matthias P Wymann
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Matthias P Wymann
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Matthias P Wymann
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prefLabel
Matthias P Wymann
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Matthias P Wymann
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Matthias P Wymann
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Matthias P Wymann
@nl
Matthias P Wymann
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P1006
P214
P244
P1006
P106
P21
P214
P244
nb2012009262
P31
P496
0000-0003-3349-4281
P735
P7859
lccn-nb2012009262