In vivo delivery of DN:REST improves transcriptional changes of REST-regulated genes in HD mice.
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Multiple Aspects of Gene Dysregulation in Huntington's DiseaseTranscriptional dysregulation in Huntington's disease: a failure of adaptive transcriptional homeostasisHigh throughput screening for inhibitors of REST in neural derivatives of human embryonic stem cells reveals a chemical compound that promotes expression of neuronal genes.Regulation of neural gene transcription by optogenetic inhibition of the RE1-silencing transcription factorSelective reduction of striatal mature BDNF without induction of proBDNF in the zQ175 mouse model of Huntington's diseaseREST alleviates neurotoxic prion peptide-induced synaptic abnormalities, neurofibrillary degeneration and neuronal death partially via LRP6-mediated Wnt-β-catenin signaling.The emerging field of epigenetics in neurodegeneration and neuroprotection.Binding of the repressor complex REST-mSIN3b by small molecules restores neuronal gene transcription in Huntington's disease models.Modulation of nuclear REST by alternative splicing: a potential therapeutic target for Huntington's disease.Dysregulation of REST-regulated coding and non-coding RNAs in a cellular model of Huntington's disease.Repressor element-1 silencing transcription factor (REST) is present in human control and Huntington's disease neurones.Modulating Neurotrophin Receptor Signaling as a Therapeutic Strategy for Huntington's Disease.Molecular insights into cortico-striatal miscommunications in Huntington's disease.Transcriptional Dysregulation and Post-translational Modifications in Polyglutamine Diseases: From Pathogenesis to Potential Therapeutic Strategies.
P2860
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P2860
In vivo delivery of DN:REST improves transcriptional changes of REST-regulated genes in HD mice.
description
2012 nî lūn-bûn
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2012年の論文
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2012年学术文章
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2012年学术文章
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2012年学术文章
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2012年学术文章
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2012年学术文章
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2012年學術文章
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name
In vivo delivery of DN:REST im ...... ST-regulated genes in HD mice.
@en
In vivo delivery of DN:REST im ...... ST-regulated genes in HD mice.
@nl
type
label
In vivo delivery of DN:REST im ...... ST-regulated genes in HD mice.
@en
In vivo delivery of DN:REST im ...... ST-regulated genes in HD mice.
@nl
prefLabel
In vivo delivery of DN:REST im ...... ST-regulated genes in HD mice.
@en
In vivo delivery of DN:REST im ...... ST-regulated genes in HD mice.
@nl
P2093
P2860
P356
P1433
P1476
In vivo delivery of DN:REST im ...... ST-regulated genes in HD mice.
@en
P2093
A Mas Monteys
B Davidson
N J Buckley
P Conforti
P2860
P2888
P304
P356
10.1038/GT.2012.84
P577
2012-11-15T00:00:00Z
P6179
1008862455