The anti-neurodegeneration drug clioquinol inhibits the aging-associated protein CLK-1.
about
Iron and neurodegeneration: from cellular homeostasis to diseaseSelective inhibition of hypoxia-inducible factor (HIF) prolyl-hydroxylase 1 mediates neuroprotection against normoxic oxidative death via HIF- and CREB-independent pathwaysA nuclear role for the respiratory enzyme CLK-1 in regulating mitochondrial stress responses and longevityImpact papers on aging in 2009.The aging-associated enzyme CLK-1 is a member of the carboxylate-bridged diiron family of proteinsDifferent 8-hydroxyquinolines protect models of TDP-43 protein, α-synuclein, and polyglutamine proteotoxicity through distinct mechanisms.Mitochondrial deficiency: a double-edged sword for aging and neurodegeneration.Substituted oxines inhibit endothelial cell proliferation and angiogenesis.The failure of mitochondria leads to neurodegeneration: Do mitochondria need a jump start?Current therapeutic targets for the treatment of Alzheimer's disease.Novel drug targets based on metallobiology of Alzheimer's disease.Metallostasis and amyloid β-degrading enzymes.Molecular genetics of ubiquinone biosynthesis in animals.Antioxidant and Metal Chelation-Based Therapies in the Treatment of Prion Disease.Cyclic cis-Locked Phospho-Dipeptides Reduce Entry of AβPP into Amyloidogenic Processing Pathway.Mitochondrial respiration without ubiquinone biosynthesis.Supramolecular synthon pattern in solid clioquinol and cloxiquine (APIs of antibacterial, antifungal, antiaging and antituberculosis drugs) studied by ³⁵Cl NQR, ¹H-¹⁷O and ¹H-¹⁴N NQDR and DFT/QTAIM.A single biochemical activity underlies the pleiotropy of the aging-related protein CLK-1.Memory restorative ability of clioquinol in copper-cholesterol-induced experimental dementia in mice.The anti-neurodegenerative agent clioquinol regulates the transcription factor FOXO1a.
P2860
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P2860
The anti-neurodegeneration drug clioquinol inhibits the aging-associated protein CLK-1.
description
2008 nî lūn-bûn
@nan
2008年の論文
@ja
2008年学术文章
@wuu
2008年学术文章
@zh
2008年学术文章
@zh-cn
2008年学术文章
@zh-hans
2008年学术文章
@zh-my
2008年学术文章
@zh-sg
2008年學術文章
@yue
2008年學術文章
@zh-hant
name
The anti-neurodegeneration drug clioquinol inhibits the aging-associated protein CLK-1.
@en
The anti-neurodegeneration drug clioquinol inhibits the aging-associated protein CLK-1.
@nl
type
label
The anti-neurodegeneration drug clioquinol inhibits the aging-associated protein CLK-1.
@en
The anti-neurodegeneration drug clioquinol inhibits the aging-associated protein CLK-1.
@nl
prefLabel
The anti-neurodegeneration drug clioquinol inhibits the aging-associated protein CLK-1.
@en
The anti-neurodegeneration drug clioquinol inhibits the aging-associated protein CLK-1.
@nl
P2093
P2860
P356
P1476
The anti-neurodegeneration drug clioquinol inhibits the aging-associated protein CLK-1.
@en
P2093
Abdelmadjid Hihi
Kevin McBride
Marie-Pierre Guimond
Melissa Carroll
Robyn Branicky
Siegfried Hekimi
Steve Hayes
Zaruhi Stepanyan
P2860
P304
P356
10.1074/JBC.M807579200
P407
P577
2008-10-15T00:00:00Z