Long-term memory deficits in Huntington's disease are associated with reduced CBP histone acetylase activity.
about
Huntingtin is critical both pre- and postsynaptically for long-term learning-related synaptic plasticity in AplysiaPhosphodiesterase-5 Inhibitors: Action on the Signaling Pathways of Neuroinflammation, Neurodegeneration, and CognitionTranscriptional dysregulation in Huntington's disease: a failure of adaptive transcriptional homeostasisEpigenetic Changes in Neurodegenerative DiseasesHdhQ111 Mice Exhibit Tissue Specific Metabolite Profiles that Include Striatal Lipid AccumulationA broad phenotypic screen identifies novel phenotypes driven by a single mutant allele in Huntington's disease CAG knock-in mice.Promoter-bound p300 complexes facilitate post-mitotic transmission of transcriptional memoryA selective inhibitor of histone deacetylase 3 prevents cognitive deficits and suppresses striatal CAG repeat expansions in Huntington's disease miceThe role of histone acetylation in memory formation and cognitive impairments.Onset of Huntington's disease: can it be purely cognitive?Crebinostat: a novel cognitive enhancer that inhibits histone deacetylase activity and modulates chromatin-mediated neuroplasticity.A phenotypic screening assay for modulators of huntingtin-induced transcriptional dysregulation.Regulation of hippocampal cGMP levels as a candidate to treat cognitive deficits in Huntington's disease.Differential Changes in Postsynaptic Density Proteins in Postmortem Huntington's Disease and Parkinson's Disease Human Brains.Polyglutamine (polyQ) disorders: the chromatin connection.A role for Kalirin-7 in corticostriatal synaptic dysfunction in Huntington's diseaseEffects of Pin1 Loss in Hdh(Q111) Knock-in Mice.Role of histone acetylation in long-term neurobehavioral effects of neonatal Exposure to sevoflurane in ratsInositol polyphosphate multikinase is a transcriptional coactivator required for immediate early gene inductionAcetyltransferases (HATs) as targets for neurological therapeuticsA Longitudinal Operant Assessment of Cognitive and Behavioural Changes in the HdhQ111 Mouse Model of Huntington's Disease.A small molecule TrkB ligand reduces motor impairment and neuropathology in R6/2 and BACHD mouse models of Huntington's disease.LBH589, A Hydroxamic Acid-Derived HDAC Inhibitor, is Neuroprotective in Mouse Models of Huntington's Disease.Contribution of Neuroepigenetics to Huntington's Disease.The finger of an angel: memory return with epigenetic manipulation.Lysine acetyltransferases CBP and p300 as therapeutic targets in cognitive and neurodegenerative disorders.Targeting specific HATs for neurodegenerative disease treatment: translating basic biology to therapeutic possibilities.Pharmacological protein targets in polyglutamine diseases: mutant polypeptides and their interactors.Genetic modifiers of Huntington's disease.Targeting histone deacetylases: a novel approach in Parkinson's disease.Histone modifying enzymes: novel disease biomarkers and assay development.Cognitive dysfunction in Huntington's disease: mechanisms and therapeutic strategies beyond BDNF.The p75 neurotrophin receptor regulates cranial irradiation-induced hippocampus-dependent cognitive dysfunction.Neurotrophin receptor p75(NTR) mediates Huntington's disease-associated synaptic and memory dysfunction.Regulation of proliferation and histone acetylation in embryonic neural precursors by CREB/CREM signaling.Fingolimod (FTY720) enhances hippocampal synaptic plasticity and memory in Huntington's disease by preventing p75NTR up-regulation and astrocyte-mediated inflammation.PDE10 inhibition increases GluA1 and CREB phosphorylation and improves spatial and recognition memories in a Huntington's disease mouse model.Prostaglandin E2 EP1 receptor antagonist improves motor deficits and rescues memory decline in R6/1 mouse model of Huntington's disease.High resolution time-course mapping of early transcriptomic, molecular and cellular phenotypes in Huntington's disease CAG knock-in mice across multiple genetic backgrounds.Cyclic nucleotide signaling changes associated with normal aging and age-related diseases of the brain.
P2860
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P2860
Long-term memory deficits in Huntington's disease are associated with reduced CBP histone acetylase activity.
description
2011 nî lūn-bûn
@nan
2011年の論文
@ja
2011年学术文章
@wuu
2011年学术文章
@zh-cn
2011年学术文章
@zh-hans
2011年学术文章
@zh-my
2011年学术文章
@zh-sg
2011年學術文章
@yue
2011年學術文章
@zh
2011年學術文章
@zh-hant
name
Long-term memory deficits in H ...... BP histone acetylase activity.
@en
Long-term memory deficits in H ...... BP histone acetylase activity.
@nl
type
label
Long-term memory deficits in H ...... BP histone acetylase activity.
@en
Long-term memory deficits in H ...... BP histone acetylase activity.
@nl
prefLabel
Long-term memory deficits in H ...... BP histone acetylase activity.
@en
Long-term memory deficits in H ...... BP histone acetylase activity.
@nl
P2093
P2860
P50
P356
P1476
Long-term memory deficits in H ...... CBP histone acetylase activity
@en
P2093
M Puigdellívol
O Carretón
P Paoletti
P2860
P304
P356
10.1093/HMG/DDR552
P577
2011-11-24T00:00:00Z