Senescence-Associated Secretory Phenotype (SASP) - Wikidata - wikimedia - TriplyDB

Senescence-Associated Secretory Phenotype (SASP)

Senescence-Associated Secretory Phenotype (SASP)

http://www.wikidata.org/entity/Q45314181

about

CDKN1A (p21) prevents association of Cyclin A:Cdk2 with Cdh1 CDKN1A (p21) prevents phosphorylation of Cdh1 by Cyclin A:Cdk2 Cdh1:APC/C complex binds EHMT1:EHMT2 Cdh1:APC/C ubiquitinates EHMT1 and EHMT2 EHMT1:EHMT2 methylates IL6 promoter EHMT1:EHMT2 methylates IL8 promoter ERK1/2/5 activate RSK1/2/3 MAPK3 (ERK1) and MAPK1 (ERK2) phosphorylate CEBPB RPS6KA1/2/3 phosphorylates CEBPB on S321 CEBPB homodimerization Activated CEBPB and NFKB complex bind IL6 promoter Stimulation of IL6 transcription in senescent cells Activated STAT3 positively regulates CEBPB transcription Activated CEBPB and NFKB complex bind IL8 promoter Stimulation of IL8 transcription in senescent cells Activated CEBPB binds CDKN2B promoter Activated CEBPB stimulates transcription of CDKN2B AP-1 transcription factor binds IGFBP7 promoter AP-1 stimulates transcription of IGFBP7 AP-1 transcription factor binds IL1A promoter AP-1 stimulates IL1A transcription

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Cellular Senescence

P527

Cellular senescence and senescence-associated secretory phenotype: comparison of idiopathic pulmonary fibrosis, connective tissue disease-associated interstitial lung disease, and chronic obstructive pulmonary disease

P921

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P361

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P527

Q64081019-DEA1EBAE-3195-4968-ACA7-F04DB4186F64

P921

Senescence-Associated Secretory Phenotype (SASP)

http://www.wikidata.org/entity/Q45314181

description

An instance of the biological ...... enotype (SASP) in Homo sapiens

@en

name

Senescence-Associated Secretory Phenotype (SASP)

@en

type

label

Senescence-Associated Secretory Phenotype (SASP)

@en

prefLabel

Senescence-Associated Secretory Phenotype (SASP)

@en

P2860

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P2888

Q45314181-A00AF667-610D-46E7-8CBC-784D58872CB2

P31

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P361

Q45314181-6A06B28A-14CB-49F6-844B-9FB0B399F843

P3937

Q45314181-93BE0B43-C134-432B-88F1-F8195F29C066

P527

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P703

Q45314181-D7E1D658-B3E0-478B-9247-B3F5B009F30E

P2860

Oncogene-induced senescence relayed by an interleukin-dependent inflammatory network.

Chemokine signaling via the CXCR2 receptor reinforces senescence

Transcription factors NF-IL6 and NF-kappa B synergistically activate transcription of the inflammatory cytokines, interleukin 6 and interleukin 8

Phosphorylation at threonine-235 by a ras-dependent mitogen-activated protein kinase cascade is essential for transcription factor NF-IL6

Interleukin-1 alpha activates an NF-kappaB-like factor in osteoclast-like cells

The transcription factor AP-1 binds to the human interleukin 1 alpha promoter

Senescence-associated secretory phenotypes reveal cell-nonautonomous functions of oncogenic RAS and the p53 tumor suppressor

RSK-mediated phosphorylation in the C/EBP{beta} leucine zipper regulates DNA binding, dimerization, and growth arrest activity

A complex secretory program orchestrated by the inflammasome controls paracrine senescence.

SASP reflects senescence.

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reactome:R-HSA-2559582

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biological pathway

P361

Cellular Senescence

P3937

R-HSA-2559582

http://www.w3.org/2001/XMLSchema#string

P527

Association of INK4 with CDK4/6

CDKN1A (p21) prevents association of Cyclin A:Cdk2 with Cdh1

CDKN1A (p21) prevents phosphorylation of Cdh1 by Cyclin A:Cdk2

Cdh1:APC/C complex binds EHMT1:EHMT2

Cdh1:APC/C ubiquitinates EHMT1 and EHMT2

EHMT1:EHMT2 methylates IL6 promoter

EHMT1:EHMT2 methylates IL8 promoter

ERK1/2/5 activate RSK1/2/3

MAPK3 (ERK1) and MAPK1 (ERK2) phosphorylate CEBPB

RPS6KA1/2/3 phosphorylates CEBPB on S321

P703