about
Phosphorylation of SMAD2 and SMAD3 linker regions by CDK8 or CDK9ATP1B4 binds SNW1WWTR1 binds SMAD2/3:SMAD4 heterotrimerWWTR1:SMAD translocates to the nucleusWWTR1:SMAD stimulates transcription of SMAD7WWTR1:SMAD stimulates transcription of SERPINE1 while TGIF:SMAD and SMAD7 inhibit itRNF111 binds SMAD7RNF111 ubiquitinates SMAD7Degradation of Ub-SMAD7SMAD2/3:SMAD4 heterotrimer forms a complex with RBL1; E2F4/5 and DP1/2MYC trancscription is negatively regulated by SMAD2/3:SMAD4:RBL1:E2F4/5:DP1/2 complexSMAD2/3:SMAD4 heterotrimer binds SP1SMAD2/3:SMAD4:SP1 complex stimulates transcription of CDKN2BMEN1 binds SMAD2/3:SMAD4 heterotrimerSMAD2/3:SMAD4 complex positively regulates JUNB transcription
P361
Q50290101-B2CC8E46-96D8-4B62-B17C-D44DEE0BF458Q50290102-CA77038E-AE26-4647-A7EA-1AC7687689ACQ50290103-47CA8221-7C93-4B3A-822D-F94F51A3646EQ50290104-75DAF32B-3C07-46AF-B642-D26E3C544079Q50290105-9138440C-E056-4085-9E69-8FC533DEC494Q50290106-D7559AB3-8917-42C5-9638-B53D029DEB58Q50290107-9FEA557A-A8DE-499D-A0BA-DF26C6C92A55Q50290108-CA40CEA5-3312-486B-8C3C-D87FA6B4C498Q50290109-D708A36A-750A-4272-9543-542CBCCD33EEQ50290111-91DF0A4C-FEDD-4AFE-B416-5AA2000EF877Q50290112-E1184DCD-03C1-4950-ADCD-EC289817F55AQ50290114-06C1307E-0D3A-4725-BF3E-825234E1CA8EQ50290115-89540380-89BD-4178-9DFA-9398E2A4B7FDQ50290116-FE608982-A748-4210-A730-13E76430BDF8Q50290117-0BAAADE6-98B0-4D05-AF4F-A539B23950CF
P361
description
An instance of the biological ...... transcription in Homo sapiens
@en
name
SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription
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type
label
SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription
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prefLabel
SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription
@en
P2860
P527
P2860
P3937
R-HSA-2173796