Design and synthesis of tricyclic JAK3 inhibitors with picomolar affinities as novel molecular probes.
about
Tofacitinib and analogs as inhibitors of the histone kinase PRK1 (PKN1).Novel hinge-binding motifs for Janus kinase 3 inhibitors: a comprehensive structure-activity relationship study on tofacitinib bioisosteres.Development of Selective Covalent Janus Kinase 3 Inhibitors.Tricyclic covalent inhibitors selectively target Jak3 through an active site thiol.2-(3-{(3R,4R)-4-Methyl-3-[meth-yl(7H-pyrrolo-[2,3-d]pyrimidin-4-yl)amino]-piperidin-1-yl}oxetan-3-yl)aceto-nitrile monohydrate.Selective JAK3 Inhibitors with a Covalent Reversible Binding Mode Targeting a New Induced Fit Binding Pocket.
P2860
Design and synthesis of tricyclic JAK3 inhibitors with picomolar affinities as novel molecular probes.
description
2014 nî lūn-bûn
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2014年の論文
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2014年学术文章
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2014年学术文章
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2014年学术文章
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2014年学术文章
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2014年学术文章
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2014年學術文章
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name
Design and synthesis of tricyc ...... ies as novel molecular probes.
@en
Design and synthesis of tricyc ...... ies as novel molecular probes.
@nl
type
label
Design and synthesis of tricyc ...... ies as novel molecular probes.
@en
Design and synthesis of tricyc ...... ies as novel molecular probes.
@nl
prefLabel
Design and synthesis of tricyc ...... ies as novel molecular probes.
@en
Design and synthesis of tricyc ...... ies as novel molecular probes.
@nl
P2860
P356
P1433
P1476
Design and synthesis of tricyc ...... ies as novel molecular probes.
@en
P2093
Ellen Pfaffenrot
Silke Bauer
P2860
P304
P356
10.1002/CMDC.201300520
P577
2014-01-08T00:00:00Z