Identification of imidazo-pyrrolopyridines as novel and potent JAK1 inhibitors
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FGFR1 Kinase Inhibitors: Close Regioisomers Adopt Divergent Binding Modes and Display Distinct Biophysical SignaturesMolecular basis for pseudokinase-dependent autoinhibition of JAK2 tyrosine kinase.Selective JAK inhibitors in development for rheumatoid arthritis.Novel hinge-binding motifs for Janus kinase 3 inhibitors: a comprehensive structure-activity relationship study on tofacitinib bioisosteres.Novel 3-Substituted 7-Phenylpyrrolo[3,2-f]quinolin-9(6H)-ones as Single Entities with Multitarget Antiproliferative ActivityUncoupling JAK2 V617F activation from cytokine-induced signalling by modulation of JH2 αC helix.Selective JAK1 inhibitor and selective Tyk2 inhibitor patents.Toward selective TYK2 inhibitors as therapeutic agents for the treatment of inflammatory diseases.Selective JAK inhibitors.Progress toward JAK1-selective inhibitors.Tricyclic covalent inhibitors selectively target Jak3 through an active site thiol.Resolving TYK2 locus genotype-to-phenotype differences in autoimmunity.A probabilistic method to report predictions from a human liver microsomes stability QSAR model: a practical tool for drug discovery.1-[(3RS,4RS)-1-Benzyl-4-methyl-piperi-din-3-yl]-1,6-dihydro-imidazo[4,5-d]pyrrolo-[2,3-b]pyridine hemihydrate.Structural modeling of JAK1 mutations in T-cell acute lymphoblastic leukemia reveals a second contact site between pseudokinase and kinase domains.Design and synthesis of tricyclic JAK3 inhibitors with picomolar affinities as novel molecular probes.Development of a high-throughput crystal structure-determination platform for JAK1 using a novel metal-chelator soaking system.Molecular modeling-driven approach for identification of Janus kinase 1 inhibitors through 3D-QSAR, docking and molecular dynamics simulations.Pharmacophore and docking-based virtual screening approach for the design of new dual inhibitors of Janus kinase 1 and Janus kinase 2.Evaluation of WO2012037132 - a novel scaffold for selective JAK1 inhibition.
P2860
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P2860
Identification of imidazo-pyrrolopyridines as novel and potent JAK1 inhibitors
description
2012 nî lūn-bûn
@nan
2012 թուականի Յունիսին հրատարակուած գիտական յօդուած
@hyw
2012 թվականի հունիսին հրատարակված գիտական հոդված
@hy
2012年の論文
@ja
2012年論文
@yue
2012年論文
@zh-hant
2012年論文
@zh-hk
2012年論文
@zh-mo
2012年論文
@zh-tw
2012年论文
@wuu
name
Identification of imidazo-pyrrolopyridines as novel and potent JAK1 inhibitors
@ast
Identification of imidazo-pyrrolopyridines as novel and potent JAK1 inhibitors
@en
Identification of imidazo-pyrrolopyridines as novel and potent JAK1 inhibitors
@nl
type
label
Identification of imidazo-pyrrolopyridines as novel and potent JAK1 inhibitors
@ast
Identification of imidazo-pyrrolopyridines as novel and potent JAK1 inhibitors
@en
Identification of imidazo-pyrrolopyridines as novel and potent JAK1 inhibitors
@nl
prefLabel
Identification of imidazo-pyrrolopyridines as novel and potent JAK1 inhibitors
@ast
Identification of imidazo-pyrrolopyridines as novel and potent JAK1 inhibitors
@en
Identification of imidazo-pyrrolopyridines as novel and potent JAK1 inhibitors
@nl
P2093
P50
P3181
P356
P1476
Identification of imidazo-pyrrolopyridines as novel and potent JAK1 inhibitors
@en
P2093
Adam Johnson
Bohdan Waszkowycz
Christine Chang
Christopher A Hurley
Hazel J Dyke
Jane R Kenny
Janusz J Kulagowski
Jeremy Murray
Kyle Mortara
Paul Gibbons
P304
P3181
P356
10.1021/JM300438J
P407
P50
P577
2012-06-28T00:00:00Z