about
Intestinal tumorigenesis initiated by dedifferentiation and acquisition of stem-cell-like propertiesmTORC1-mediated translational elongation limits intestinal tumour initiation and growth.E-cadherin can limit the transforming properties of activating β-catenin mutations.MYC Is a Major Determinant of Mitotic Cell Fate.Inhibition of CXCR2 profoundly suppresses inflammation-driven and spontaneous tumorigenesis.ROS production and NF-κB activation triggered by RAC1 facilitate WNT-driven intestinal stem cell proliferation and colorectal cancer initiation.Stem vs non-stem cell origin of colorectal cancer.The Rac-FRET mouse reveals tight spatiotemporal control of Rac activity in primary cells and tissuesADF and Cofilin1 Control Actin Stress Fibers, Nuclear Integrity, and Cell Survival.Methods to assess Myc function in intestinal homeostasis, regeneration, and tumorigenesis.The APC network regulates the removal of mutated cells from colonic crypts.
P50
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P50
description
hulumtues
@sq
researcher
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wetenschapper
@nl
հետազոտող
@hy
name
David J Huels
@ast
David J Huels
@en
David J Huels
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David J Huels
@nl
David J Huels
@sl
type
label
David J Huels
@ast
David J Huels
@en
David J Huels
@es
David J Huels
@nl
David J Huels
@sl
prefLabel
David J Huels
@ast
David J Huels
@en
David J Huels
@es
David J Huels
@nl
David J Huels
@sl
P108
P106
P21
P31
P496
0000-0001-6154-1183